Dietary carbohydrates that escape digestion and absorption in the small intestine include non- digestible oligosaccharides (carbohydrates with a degree of polymerisation between three and ten), resistant starch and non-starch polysaccharides. The physiological effects of this heterogeneous mixture of substrates are partly predictable on the basis of their physicochemical properties. Mono saccharide composition and chain conformation influence the rate and extent of fermentation. Water-holding capacity affects stool weight and intestinal transit time. Viscous polysaccharides can cause delayed gastric emptying and slower transit through the small bowel, resulting in the reduced rate of nutrient absorption. Polysaccharides with large hydrophobic surface areas have potentially important roles in the binding of bile acids, car cinogens and mutagens. Ispaghula is capable of binding bile acids through a large number of weak binding sites on the polysaccharide structure, and having greatest effect on the potentially more harmful secondary bile acids deoxycholic acid and lithocholic acid.
Agte V. and Joshi S. (1991). In vitro binding of bile salts with plant fibres . J Food Sci Technol, 28, 226-229
2.
Alberts D.S., Rittenbaugh C., Story J.A., Aickin M., Mcgee S.R., Buller M.K.,
3.
Atwood J., Phelps J., Ramanujam P.S., Bellapravalu S., Patel J., Bettinger L. and Clark L. (1996). Randomized, double-blinded, placebo-controlled study of effect of wheat bran fiber and calcium on fecal bile acids in patients with resected adenomatous colon polyps. J Nad Cancer Inst , 88, 81-92
4.
Alder R.J., Mckeown-Eyssen G. and Bright-See E. (1993). Randomized trial of the effect of calcium supplementation on faecal risk factors for colorectal cancer. Am J Epidemiol ; 138(10), 804-814
5.
Anderson J.W., Zettwoch N., Feldman T., Tietyen-Clark J., Oeltgen P. and Bishop C.W. (1988). Cholesterol lowering effects of psyllium hydrophilic mucilloid for hypercholesterolemic men. Arch Intern Med; 148, 292-296
6.
Anderson J.W., Deakins D.A., Floore T.L., Smith B.M. and Whitis S.E. (1990). Dietary fiber and coronary heart disease. Crit Rev Food Sci Nutr, 29, 95-147
7.
Archer S., Meng S., Wu J., Johnson J., Tang R. and Hodin R. (1998). Butyrate inhibits colon carcinoma cell growth through two distinct pathways. Surgery, 124, 248-253
8.
Balasubramanian D., Raman B. and Sivakama Sundari C. (1993). Polysaccharides as amphiphiles . J Am Chem Soc,115, 74-77
9.
Blake D.E., Hamblett C.J., Frost P.G., Judd P.A. and Ellis P.R. (1997). Wheat bread supplemented with depolymerised guar gum reduces the plasma cholesterol concentration in hypercholesterolaemic human subjects. Am J Clin Nutr; 65,107-113
10.
Boyd G.S., Eastwood M.A. and Maclean J. (1966). Bile acids in the rat: studies in experimental occlusion of the bile duct. J Lipid Res, 7, 83-94
11.
Cassidy A., Bingham S.A. and Cummings J.H. (1994). Starch intake and colorectal cancer risk: an international comparison. Br J Cancer, 69, 937-942
12.
Chaplin M.F. (1998). Bile acids, fibre and colon cancer: the story unfolds. J Royal Soc Health; 118, 53-61
13.
Clayton B.D., Berry C.S., Conning D.M., et al (1990). Interactions between complex carbohydrates and bacteria. In: BNF Task Force on Complex Carbohydrates in Foods, pp. 45-55. London: The British Nutrition Foundation/Chapman and Hall
14.
Eastwood M.A. and Hamilton D. (1968). Studies on the adsorption of bile salts to non-absorbed components of diet. Biochim Biophys Acta; 152,165-173
15.
Eherer A.J., Ana C A S, Porter J. and Fordtran J.S. (1993). Effect of psyllium, calcium polycarbophil and wheat bran on secretory diarrhoea induced by phenolphthalein. Gastroenterol, 104, 1007-1012
16.
Ellis P.R. (1994). Polysaccharide gums: their modulation of carbohydrate and lipid metabolism and role in the treatment of diabetes mellitus. In: Gums and stabilisers for the food industry, pp. 207-216 ( G O Philips, DJ Wedlock and P A Williams). Oxford: Pergamon
17.
Faivre J., Doyon F. and Boutron M. (1991). The ECP calcium fibre polyp prevention study. Eur J Cancer Prevent; 1, 83-89
18.
Faivre J. and Giacosa A. (1998). Primary prevention of colorectal cancer through fibre supplementation. Eur J Cancer Prevent; 7, S29-S32
19.
Haskell W.L., Spiller G.A., Jensen C.D., Ellis B.K. and Gates J.E. (1992). Role of watersoluble dietary fiber in the management of elevated plasma cholesterol in healthy subjects. Am J Cardiol ; 69, 433-439
20.
Heuman D.M. (1989). Quantitative estimation of the hydrophilic-hydrophobic balance of mixed bile salt solutions. J Lipid Res; 30, 719-729
21.
Hidaka H., Eida T., Takizawa T., Toku-Naga T. and Tashiro Y. (1986) Effects of fructooligosaccharides on intestinal flora and human health. Bifidobacteria Microflora; 5, 37-50
22.
Hill M.J. (1991). Bile acids and colorectal cancer. Eur J Cancer Prevent, 1 (2), 69-72
23.
Hill M.J. (1997). Cereals, cereal fibre and colorectal cancer risk: a review of the epidemiological literature. Eur J Cancer Prevent ; 6, 219-225
24.
Hofmann A.F. and Roda A. (1984). Physicochemical properties of bile acids and their relationships to biological properties: an overview of the problem. J Lipid Res; 25, 1477-1489
25.
Huang C.M. and Dural N.H. (1995). Adsorption of bile-acids on cereal type food fibers . J Food Process Eng, 18, 243-266
26.
Jaskari J., Kontula P., Siitonen A., Jousimies-Somer H., Mattila-Sandholm T. and Poutanen K. (1998). Oat beta-glucan and xylan hydrolysates as selective substrates for bifidobacterium and lactobacillus strains. Appl Micro Biotech; 49, 175-181
27.
Jenkins D.J., Goff D.V., Leeds A.R., et al (1976). Unabsorbable carbohydrates and diabetes: decreased post-prandial hyperglycaemia. Lancet; 2, 172-174
28.
Jenkins D J A, Jenkins A.L., Wolever T.M., Vuskan V., Rao, A.V., Thompson L.U. and Josse R.G. (1995). Dietary fibre, carbohydrate metabolism and diabetes . In: Dietary Fibre, pp. 137-145 ( D Kritchevsky, C Bonfield and J W Anderson). New York: Plenum Press
29.
Kay R.M., Strasberg S.M., Petrunka C.N. and Wayman M. (1979). Differential adsorption of bile acids by lignins . In: Dietary Fibres: Chemistry and Nutrition, pp. 57-66 ( G Inglett and I Falkehag). New York: Academic Press
30.
Kishida T., Taguchi F., Feng L., Tatsug-Uchi A., Sato J., Fujimori S., Tachikawa H., Tamagaway Y., Yushida Y. and Kobayashi M. (1997). Analysis of bile acids in colon residual liquid or fecal material in patients with colorectal neoplasia and control subjects . J Gastroenterol; 32, 306-311
31.
Kritchevsky D. (1991). Bile acids: biosynthesis and functions. Eur J Cancer Prevent, 1, 23-28
32.
Lairon D. (1996). Dietary fibres: effects on lipid metabolism and mechanisms of action. Eur J Clin Nutr, 50,125-133
33.
Lampe J.W., Slavin J.L., Melcher E.A. and Potter J.D. (1992). Effects of cereal and vegetable fibre feeding on potential risk-factors for colon cancer. Cancer Epidemiol Biomarkers Prevent, 1, 207-211
34.
La Vecchia C. and Chatenoud L. (1998). Fibres, whole grain foods and breast and other cancers. Eur J Cancer Prevent, 7, S25-S28
35.
Leclere C.L., Champ M., Boillot J., Guille G., Lecannu G., Molis C., Bornet F., Krempf M., Delort-Laval J. and Galmiche J-P. (1994). Role of viscous guar gum in lowering the glycemic response after a solid meal. Am J Nutr, 59, 914-921
36.
Lennard Jones J.E. (1993). Clinical management of constipation. Pharmacol; 47 (S1), 216-223
37.
Macfarlane G.T. and Cummings J.H. (1991). The colonic flora, fermentation and large bowel digestive function. In: The large intestine: physiology, pathophysiology and disease, pp. 51-92. (Edited by S F Philips, J H Pemberton and R G Shorter ). New York: Raven Press
38.
May T., Mackie R.I., Fahey JR G.C., Cremin J.C. and Garleb K.A. (1994). Effect of fiber source on short-chain fatty acid production and on the growth and toxin production by Clostridium difficile . Scand J Gastroenterol ; 19, 916-922
39.
Owen R.W., Henly P.J., Thompson M.H. and Hill M.J. (1986). Steroids and cancer: Faecal bile acid screening for early detection of cancer risk. J Steroid Biochem; 24, 391-394
40.
Prosky L. and Lee S.C. (1997). Classification of complex carbohydrates. In: Dietary fiber in health and disease, pp. 55-61. (Edited by D Kritchevsky and C Bonfield ). New York: Plenum Press
41.
Rao V S R, Qasba P.K., Balaji P.V. and Chandrasekaran R. (1998). Folding patterns of homopolysaccharides . In: Conformation of carbohydrates, pp. 191-221. Singapore : Harwood Academic
42.
Read N.W., Welch I.M., Austen C.J., et al (1986). Swallowing food without chewing: a simple way to reduce postprandial glycaemia. Br J Nutr, 55, 43-47
43.
Reddy B.S. (1993). Nutritional factors as modulators of colon carcinogenesis . In: Food, nutrition and chemical toxicity, pp. 325-336. (Edited by D V Parke, C Ioannides and R Walker). London: Smith-Gordon
44.
Reddy B.S., Engle A., Katsifis S., Simi B., Bartram H.P., Perrino P. and Mahan C. (1989). Biochemical epidemology of colon cancer: effect of types of dietary fibre on fecal mutagens, acid and neutral sterols in healthy subjects. Cancer Res; 49, 4629-4635
45.
Roda A. and Fini A. ( 1984). Effect of nuclear hydroxy substituents on aqueous solubility and acidic strength of bile acids. Hepatol; 4, 725-765
46.
Scheppach W., Bartram H.P. and Richter F. (1995). Role of short-chain fatty-acids in the prevention of colorectal-cancer. Eur J Cancer, 31A, 1077-1080
47.
Stephen A.M. (1991). Starch in human nutrition. Symposium Proceedings . Can J Physiol Pharmacol; 69, 53-136
48.
Stephen A.M., Haddad A.C. and Philips S.F. (1983). Passage of carbohydrate into the colon- direct measurements in humans. Gastroenterol, 85, 589-595
49.
Story J.A. and Kritchevsky D. (1976). Comparison of the binding of various bile acids and bile salts in vitro by several types of fibre. J Nutr , 106, 1292-1294
50.
Velazquez M., Davies C., Marett R., Slavin J.L. and Feirtag J.M. (2000). Effect of oligosaccharides and fibre substitutes on short-chain fatty acid production by human faecal microflora. Anaerobe; 6, 87-92
51.
Vlahcevic Z.R., Heuman D.M. and Hyle-Mon P.B. (1991). Regulation of bile acid synthesis. Hepatol; 13, 590-600
52.
Wang X. and Gibson G.R. (1993). Effects of the in vitro fermentation of oligofructose and inulin by bacteria growing in the human large intestine. J Appl Bacteriol; 75, 373-380
53.
Wursch P., Del Vedovo S. and Koell-Reutter B. (1986). Cell structure and starch nature as key determinants of the digestion rate of starch in legumes. Am J Clin Nutr, 43, 25-29
54.
Yazawa K., Imai K. and Tamura Z. (1978). Oligosaccharides and polysaccharides specifically utilisable by bifidobacteria. Chem Pharm Bull ; 26, 3306-3311
