Traumatic brain injury (TBI) is the commonest worldwide cause of death and disability in people under 45 years of age. Following an injury of this nature, physiological derangements, both systemic and within the brain, rapidly progress and have a deleterious effect on outcome. There is a lack of brain specific treatments that significantly improve outcome and management must therefore be best care of appropriate physiology, along the familiar ABC lines. There are international guidelines that describe targets to be achieved. Methods to do this plus the rationale for doing so are discussed in this article.
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