Physiological response in the injured transplant patient

Abstract

Solid organ transplantation as a treatment for end organ failure is increasing in success. Consequently there are more transplant recipients leading more active lifestyles, resulting in an increasing number presenting as an emergency to hospitals remote from their transplant centre as victims of trauma. A basic knowledge of the anatomy, physiology and pharmacology specific to this group of patients is prerequisite to their successful management. Following a brief history, the incidence and indication for each type of solid organ transplant is detailed, followed by relevant anatomy and physiology. An overview of current immunosuppression and its related side-effects is followed by a discussion concerning vascular access and invasive monitoring.