Medical Support and Surgery of the Failing Heart: Levosimendan

Thackray S Easthaugh J Freemantle N Cleland JG : The effectiveness and relative effectiveness of intravenous inotropic drugs acting through the adrenergic pathway in patients with heart failure — A meta-regression analysis. Eur J Heart Fail 2002;4:515–529.

Fleisher LA Beckman JA Brown KA Calkins H Chaikof E Fleischmann KE Freeman WK Froehlich JB Kasper EK Kersten JR Riegel B Robb JF Smith J Jacobs AK Adams CD Anderson JL Antman EM Faxon DP Fuster V Halperin JL Hiratzka LF Hunt SA Lytle BW Nishimura R Page RL Riegel B : ACC/AHA 2006 Guideline Update on Perioperative Cardiovascular Evaluation for Noncardiac Surgery: Focused Update on Perioperative Beta-Blocker Therapy. Circulation 2006; 113:2662–2674.

Toller WG Stranz C : Levosimendan, a new inotropic and vasodilator agent. Anesthesiology 2006;104:556–569.

Cuffe MS Califf RM Adams KF Jr. Benza R Bourge R Colucci WS Massie BM O'Connor CM Pina I Quigg R Silver MA Gheorghiade M : Short-term intravenous milrinone for acute exacerbation of chronic heart failure: A randomized controlled trial. JAMA 2002; 287: 1541–1547.

Felker GM Benza RL Chandler AB Leimberger JD Cuffe MS Califf RM Gheorghiade M O'Connor CM : Heart failure etiology and response to milrinone in decompensated heart failure: Results from the OPTIME-CHF study. J Am Coll Cardiol 2003;41:997–1003.

Follath F Cleland JG Just H Papp JG Scholz H Peuhkurinen K Harjola VP Mitrovic V Abdalla M Sandell EP Lehtonen L : Efficacy and safety of intravenous levosimendan compared with dobutamine in severe low-output heart failure (the LIDO study): A randomised double-blind trial. Lancet 2002;360: 196–202.

Nanas JN Papazoglou P Tsagalou EP Ntalianis A Tsolakis E Terrovitis JV Kanakakis J Nanas SN Alexopoulos GP Anastasiou-Nana MI : Efficacy and safety of intermittent, long-term, concomitant dobutamine and levosimendan infusions in severe heart failure refractory to dobutamine alone. Am J Cardiol 2005;95:768–771.

Nijhawan N Nicolosi AC Montgomery MW Aggarwal A Pagel PS Warltier DC : Levosimendan enhances cardiac performance after cardiopulmonary bypass: A prospective, randomized placebo-controlled trial. J Cardiovasc Pharmacol 1999;34:219–228.

Lilleberg J Nieminen MS Akkila J Heikkila L Kuitunen A Lehtonen L Verkkala K Mattila S Salmenpera M : Effects of a new calcium sensitizer, levosimendan, on haemodynamics, coronary blood flow and myocardial substrate utilization early after coronary artery bypass grafting. Eur Heart J 1998; 19:660–668.

Barisin S Husedzinovic I Sonicki Z Bradic N Barisin A Tonkovic D : Levosimendan in off-pump coronary artery bypass: A four-times masked controlled study. J Cardiovasc Pharmacol 2004;44:703–708.

Sonntag S Sundberg S Lehtonen LA Kleber FX : The calcium sensitizer levosimendan improves the function of stunned myocardium after percutaneous transluminal coronary angioplasty in acute myocardial ischemia. J Am Coll Cardiol 2004;43:2177–2182.

Ellger BM Zahn PK Van Aken HK Schmidt C Brussel T : Levosimendan: A promising treatment for myocardial stunning? Anaesthesia 2006;61:61–63.

Garcia-Gonzalez MJ Dominguez-Rodriguez A : Effect of levosimendan treatment of myocardial stunning and low-output syndrome after cardiac surgery. Rev Esp Cardiol 2006;59: 851–852.

Lechner E Moosbauer W Pinter M Mair R Tulzer G : Use of levosimendan, a new inodilator, for postoperative myocardial stunning in a premature neonate. Pediatr Crit Care Med 2007; 8:61–63.

Moiseyev VS Poder P Andrejevs N Ruda MY Golikov AP Lazebnik LB Kobalava ZD Lehtonen LA Laine T Nieminen MS Lie KI : Safety and efficacy of a novel calcium sensitizer, levosimendan, in patients with left ventricular failure due to an acute myocardial infarction. A randomized, placebo-controlled, double-blind study (RUSSLAN). Eur Heart J 2002;23:1422–1432.

Kersten JR Montgomery MW Pagel PS Warltier DC : Levosimendan, a new positive inotropic drug, decreases myocardial infarct size via activation of KATP channels. Anesth Analg 2000;90:5–11.

Nieminen MS Bohm M Cowie MR Drexler H Filippatos GS Jondeau G Hasin Y Lopez-Sendon J Mebazaa A Metra M Rhodes A Swedberg K Priori SG Garcia MA Blanc JJ Budaj A Dean V Deckers J Burgos EF Lekakis J Lindahl B Mazzotta G Morais J Oto A Smiseth OA Dickstein K Albuquerque A Conthe P Crespo-Leiro M Ferrari R Follath F Gavazzi A Janssens U Komajda M Moreno R Singer M Singh S Tendera M Thygesen K : Executive summary of the guidelines on the diagnosis and treatment of acute heart failure: The Task Force on Acute Heart Failure of the European Society of Cardiology. Eur Heart J 2005;26:384–416.