Dynamic light scattering (DLS) spectroscopy measures changes in the Brownian movement of particles at the molecular level. Since the retina of the eye is a neural tissue and an outgrowth of the brain, a clinical instrument was developed capable of making DLS measurements from the retina in patients with mild cognitive impairment undergoing positron emission tomography nuclide imaging for the presence of cerebral amyloid.
KoronyoYRentsendorjAMirzaeiN, et al.Retinal pathological features and proteome signatures of Alzheimer's disease. Acta Neuropathol2023; 145: 409–438.
2.
KashaniAHAsanadSChanJW, et al.Past, present and future role of retinal imaging in neurodegenerative disease. Prog Retin Eye Res2021; 83: 100938.
3.
UchidaAPillaiJABermelR, et al.Correlation between brain volume and retinal photoreceptor outer segment volume in normal aging and neurodegenerative diseases. PLoS One2020; 15: e0237078.
4.
AshokASinghNChaudharyS, et al.Retinal degeneration and Alzheimer’s disease: an evolving link. Int J Mol Sci2020; 21: 7290.
5.
SantosCYJohnsonLNSinoffSE, et al.Change in retinal structural anatomy during the preclinical stage of Alzheimer’s disease. Alzheimers Dement (Amst)2018; 10: 196–209.
6.
SanchezDCastilla-MartiMMarquieM, et al.Evaluation of macular thickness and volume tested by optical coherence tomography as biomarkers for Alzheimer’s disease in a memory clinic. Sci Rep2020; 10: 1580.
7.
WeissJN. Dynamic light scattering spectroscopy of the human eye. Cham, Switzerland: Springer, 2022.
8.
WeissJN. Alzheimer’s disease and the eye. Cham, Switzerland: Springer, 2024.
9.
WeissJN. Dynamic light-scattering method could guide Alzheimer’s diagnosis and treatment. BioPhotonics2023; 30: 46–49.
10.
WeissJN. Dynamic light scattering of the eye in the diagnosis of Alzheimer's disease. J Alzheimers Dis. Epub ahead of print 25 Nov 2024. DOI: https://doi.org/10.1177/13872877241301802
