This two-part review provides a comprehensive summary of clinical and research
literature on paediatric liver transplantation. Part 2 focuses on the long-term
physical consequences and psychological impact of transplantation and critically
examines neurobehavioural, sexual development, psychosocial function and overall
impact on children’s quality of life. This review highlights the
implications for clinical practice in specialist and local services and suggests
areas where research is required to improve the lives of children after liver transplantation.
Adeback, P.
,
Nemeth, A.
and
Fischler, B.
(2003)
‘Cognitive and Emotional Outcome After Pediatric Liver Transplantation’
, Pediatric Transplantation7(5):
385-389
.
2.
Alonso, E.M.
,
Neighbors, K.
,
Mattson C.
,
Sweet, H.
,
Ruch-Ross, H.
,
Berry C.
and
Sinacore, J.
(2003)
‘Functional Outcomes of Pediatric Liver Transplantation’
, Journal of Pediatric Gastroenterology and Nutrition37(2):
155-160
.
3.
Apajasalo, M.
,
Rautonen, J.
,
Sintonen, H.
and
Holmberg, C.
(1997)
‘Health-related Quality of Life After Organ Transplantation in Childhood’
, Pediatric Transplantation1(2):
130-137
.
4.
Argao, E.A.
,
Specker, B.L.
and
Heubi, J.E.
(1993)
‘Bone Mineral Content in Infant and Children with Chronic
Cholestatic Liver Disease’
, Pediatrics91(6):
1151
.
5.
Armenti, V.T.
,
Moritz, M.J.
and
Davison, J.M.
(2003)
‘Pregnancy in Female Pediatric Solid Organ Transplant Recipients’
, Pediatric Clinics of North America50(6):
1543-1560
.
6.
Aw, M.M.
,
Samaroo, B.
,
Baker, A.J.
,
Verma, A.
,
Rela, M.
,
Heaton, N.D.
,
Mieli-Vergani, G.
and
Dhawan, A.
(2001)
‘Calcineurin-inhibitor Related Nephrotoxicity - Reversibility in
Paediatric Liver Transplant Recipients’
, Transplantation72(4):
746-749
.
7.
Aw, M.M.
,
Dhawan, A.
,
Rodrigues, A.
and
Mieli-Vergani, G.
(2002)
‘Mycophenolate Mofetil in the Treatment of Autoimmune Liver
Disease in Children’
, Journal of Pediatric Gastroenterology and Nutrition34(4):
436
.
8.
Bucuvalas, J.C.
and
Ryckman, F.C.
(2002)
‘Long-term Outcome After Liver Transplantation in Children’
, Pediatric Transplantation6(1):
30-36
.
9.
Bucuvalas, J.C.
,
Britto, M.
,
Krug, S.
,
Ryckman, F.C.
,
Atherton, H.
,
Alonso, M.P.
,
Balistreri, W.F.
and
Kotagal, U.
(2003)
‘Health-related Quality of Life in Pediatric Liver Transplant
Recipients: A Single Centre Study’
, Liver Transplantation9(1):
62-71
.
10.
Burdelski, M.
,
Nolkemper, D.
,
Ganschow, R.
,
Sturm, E.
,
Malago, M.
,
Rogiers, X.
and
Brolsch, C.E.
(1999)
‘Liver Transplantation in Children: Long-term Outcome and Quality
of Life’
, European Journal of Pediatrics158(Supp. 2):
42
.
11.
Chin, S.E.
,
Shepherd, R.W.
,
Cleghorn, G.J.
,
Patrick, M.K.
,
Javorsky, G.
,
Frangoulis, E.
,
Ong, T.H.
,
Balderson, G.
,
Koido, Y.
and
Matsunami, H.
(1991)
‘Survival, Growth and Quality of Life in Children After
Orthotopic Liver Transplantation: a 5-year Experience’
, Journal of Paediatrics and Child Health27(6):
380-385
.
12.
Codoner-Franch, P.
,
Bernard, O.
and
Alvarez, F.
(1994)
‘Long-term Follow-up of Growth in Height After Successful Liver Transplantation’
, Journal of Pediatrics124(3):
368-373
.
13.
D’Antiga, L.
,
Moniz, C.
,
Buxton-Thomas, M.
,
Cheeseman, P.
,
Gray, B.
,
Abraha, H.
,
Baker, A.J.
,
Heaton, N.D.
,
Rela, M.
,
Mieli-Vergani, G.
and
Dhawan, A.
(2002)
‘Bone Mineral Density and Height Gain in Children with Chronic
Cholestatic Liver Disease Undergoing Transplantation’
, Transplantation73(11):
1788-1793
.
14.
DeBolt, A.J.
,
Stewart, S.M.
,
Kennard, B.D.
,
Petrik, K.
and
Andrews, W.S.
(1995)
‘A Survey of Psychosocial Adaptation in Long-term Survivors of
Pediatric Liver Transplants’
, Children’s Health Care24(2):
79-96
.
15.
Dhawan, A.
and
Muiesan, P.
(1998)
‘Pediatric Liver Transplantation’
, Acta Paediatrica Japonica40(6):
525-529
.
16.
Dror, Y.
,
Greenberg, M.
,
Taylor, G.
,
Superina, R.
,
Hebert, D.
,
West, L.
,
Connolly, B.
,
Sena L.
,
Allen, U.
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Weitzman, S.
(1999)
‘Lymphoproliferative Disorders after Organ Transplantation in Children’
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.
17.
Feber, J.
,
Filler, G.
and
Cochat, P.
(2003)
‘Is Decreased Bone Mineral Density in Pediatric Transplant
Recipients Really a Problem?’
, Pediatric Transplantation7(5):
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.
18.
Gritti, D.
,
DiSarno, A.M.
,
Comito, M.
,
De Vincenzo, A.
,
De Paola, P.
and
Vajro, P.
(2001)
‘Psychological Impact of Liver Transplantation on
Children’s Inner Worlds’
, Pediatric Transplantation5(1):
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.
19.
Holt, R.I.
,
Broide, E.
,
Buchanan, C.R.
,
Miell, J.P.
,
Baker, A.J.
,
Mowat, A.P.
and
Mieli-Vergani, G.
(1997)
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20.
Jain, A.
,
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,
Fung, J.J.
,
Gartner, J.C.
,
Lever, J.
and
Balan, V.
(1997)
‘Pregnancy After Liver Transplantation Under Tacrolimus’
, Transplantation64(4):
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.
21.
Jain, A.
,
Nalesnik, M.
,
Reyes, J.
,
Pokharna, R.
,
Mazariegos, G.
,
Green, M.
,
Eghtesad, B.
,
Marsh, W.
,
Cacciarelli, T.
,
Fontes, P.
,
Abu-Elmagd, K.
,
Sindhi, R.
,
Demetris, J.
and
Fung, J.
(2002)
‘Post-transplant Lymphoproliferative Disorders in Liver
Transplantation: a 20-year Experience’
, Annals of Surgery236(4):
429-436
.
22.
Kennard, B.D.
,
Stewart, S.M.
,
Phelan-McAuliffe, D.
,
Waller, D.A.
,
Bannister, M.
and
Fioravani, V.
(1999)
‘Academic Outcome in Long-term Survivors of Pediatric Liver Transplantation’
, Journal of Developmental and Behavioral Pediatrics20(1):
17-23
.
23.
Kerkar, N.
,
Hadzi, N.
,
Davies, E.T.
,
Portmann, B.
,
Donaldson, P.T.
,
Rela, M.
,
Heaton, N.D.
,
Vergani, D.
and
Mieli-Vergani, G.
(1998)
‘De-novo Autoimmune Hepatitis After Liver Transplantation’
, The Lancet351(9100):
409-413
.
24.
Krull, K.
,
Fuchs, C.
,
Yurk, H.
,
Boone, P.
and
Alonso, E.M.
(2003)
‘Neurocognitive Outcome in Pediatric Liver Transplant Recipients’
, Pediatric Transplantation7(2):
111-118
.
25.
Laifer, S.A.
,
Darby, M.J.
,
Scantlebury, V.P.
,
Harger, J.H.
and
Caritis, S.N.
(1990)
‘Pregnancy and Liver Transplantation’
, Obstetrics and Gynecology76(6):
1083-1088
.
26.
Laine, J.
,
Krogerus, L.
,
Fyhrquist, F.
,
Jalanko, H.
,
Ronnholm, K.
and
Holmberg, C.
(1994)
‘Renal Function and Histopathologic Changes in Children After
Liver Transplantation’
, Journal of Pediatrics125(6):
9
.
27.
McDiarmid, S.V.
(2001)
‘Management of the Pediatric Liver Transplant Patient’
, Liver Transplantation7(11):
S77-S86
.
28.
Mass K.
,
Quint, E.H.
,
Punch, M.R.
and
Merion, R.M.
(1996)
‘Gynecological and Reproductive Function After Liver Transplantation’
, Transplantation62(4):
476-479
.
29.
Melzer, S.M.
,
Leadbeater, B.
,
Reisman, L.
,
Jaffe, L.R.
and
Lieberman, K.V.
(1989)
‘Characteristics of Social Networks in Adolescents with End-stage
Renal Disease Treated with Renal Transplantation’
, Journal of Adolescent Health Care10(4):
308-312
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30.
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,
Bradlee, T.A.
,
Donohoe, C.
,
Kent, K.P.
and
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(2000)
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333-339
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31.
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,
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,
Hoyer, P.F.
,
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and
Brodehl, J.
(1994)
‘Growth in Long-term Survivors After Orthotopic Liver
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, Transplantation Proceedings26(1):
165-166
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32.
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