Abstract
It seems that in both diabetic and non-diabetic postmenopausal women unopposed oestradiol replacement therapy is followed by an improvement in glucose homeostasis and a slight improvement or a neutral effect on insulin sensitivity. When progestogens are added, the beneficial oestrogen-induced effect on glucose metabolism is impaired or at least neutralised (partly dependent on the choice of progestogen). This also applies to the oestrogen effect on insulin sensitivity. An ideal progestogen should not abolish the positive effects on glucose metabolism by oestrogens and simultaneously decrease triglyceride levels in women with type 2 diabetes.
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