Fatigue and mobility are significant factors in determining quality of life in patients with multiple sclerosis. This paper briefly reviews what is known about each factor and what is currently being done clinically about each factor. We also propose research designed to enhance the ability of clinicians and patients to reduce the negative impact of increased fatigue and reduced mobility in MS.
MacLaren D., Gibson H., Parry-Billings M., Edwards R.A review of metabolic and physiological factors in fatigue. In: Pandolf K (ed.). Exercise and sport sciences reviews. Baltimore: Williams & Wilkins, 1989; 17:29-66.
2.
Enoka R., Stuart D.Neurobiology of muscle fatigue. J Appl Physiol1992;72:1631-48.
3.
Gappmaier E. , Spencer M., Hicks R., et al. Effect of a single aerobic exercise bout on vision of patients with multiple sclerosis. Med & Sci in Sports and Exercise1993;25(suppl):S43.
4.
Spencer M., Gappmaier E., Hicks R., White A., Mino L., Petajan J.Functional response to acute exercise in multiple sclerosis. Med & Sci in Sports and Exercise1993;25(suppl):S44.
5.
Ponichtera-Mulcare JA. Exercise and multiple sclerosis. Med & Sci in Sports and Exercise1993;25(4):451-65.
6.
Schapiro RTSymptom management in multiple sclerosis, 2nd ed. New York: Demos, 1994.
7.
Pepin E., Hicks R., Goodman T., Spencer M., Bonzheim K., Franklin B.Attenuated pressor response to dynamic exercise in multiple sclerosis: prediction from static exercise. Med & Sci in Sports and Exercise1993;25(suppl):S43.
8.
Fuglevand A. , Zackowski K., Huey K., Enoka R.Impairment of neuromuscular propagation during human fatiguing contractions at submaximal forces. J Physiol1993;460:549-72,
9.
Jones LARole of central and peripheral signals in force sensation during fatigue. Exp Neurol1983;81:497-503.
10.
Sandroni P. , Walker C., Starr A.Fatigue in patients with multiple sclerosis: motor pathway conduction and event-related potentials. Arch Neurol1992;49:517-24.
11.
Miller R., Carson P., Moussavi R., Boska M., Weiner M.The use of magnetic resonance spectroscopy to evaluate muscular fatigue and human muscle disease. Appl Radiology March1989; 33-38.
12.
Kent-Braun JA, Sharma KR, Weiner MW, Miller RGAltered muscle function during progressive exercise in persons with multiple sclerosis. Med & Sci in Sports and Exercise1993;25 (suppl):S43.
13.
Hubsky E., Sears J.Fatigue in multiple sclerosis: guidelines for nursing care. Rehabil Nurs1992;17:176--80.
14.
Freal JE, Kraft GH, Coryell JKSymptomatic fatigue in multiple sclerosis. Arch Phys Med Rehabil1984;65:135-38.
Cohen R., Fisher M.Amantadine treatment of fatigue associated with multiple sclerosis. Arch Neurol1989,46:676-80.
17.
Rosenberg G. , Appenzeller O.Amantadine, fatigue, and multiple sclerosis . Arch Neurol1988;45:1104-1106.
18.
Murray TJAmantadine therapy for fatigue in multiple sclerosis. Can J Neurol Sci1985;12:251-54.
19.
Weinshenker BG , Penman M., Bass B., Ebers GC, Rice Gpa.A double- blind, randomized, crossover trial of pemoline in fatigue associated with multiple sclerosis. Neurology1992;42:1468-71.
20.
Monks J.Experiencing symptoms in chronic illness: fatigue in multiple sclerosis. Int Disabil Studies1989;11:78-83.
21.
Krupp L., LaRocca N., Muir-Nash J, Steinberg A. The fatigue severity scale: application to patients with multiple sclerosis and systemic lupus erythematosus. Arch Neurol1989;46:1121-23.
22.
Halper J.The functional model in multiple sclerosis. Rehabil Nurs1990;15:77-85.
23.
Kurtzke J.The disability status scale for multiple sclerosis: apologia pro DSS sua. Neurology1989;39:291-302.
24.
Noseworthy JH, Vandervoort MK, Wong CJ, Ebers GC, CanadianCooperative MD Study Group. Interrater variability with the expanded disability status scale (EDSS) and function systems (FS) in a multiple sclerosis clinical trial. Neurology1990;40:971-75.
25.
Miller DH, Hornabrook RW, Purdie G.The natural history of multiple sclerosis: a regional study with some longitudinal data. J Neurol Neurosurg Psychiatry1992;55:341-46.
26.
Riise T., Gronning M., Fernandez O., Lauer K., Midgard R., Minderhoud JM, Nyland H., Palffy G., Poser S., Aarli J.Early prognostic factors for disability in multiple sclerosis, a European multicenter study. Acta Neurol Scand1992;85:212-18.
27.
Antel JP, Freedman MS, Brodovsky S., Francis GS, Duquette P.Activated suppressor cell function in severely disabled patients with multiple sclerosis. Ann Neurol1989,25:204-07.
28.
Trotter JL, Clifford DB, McInnis JE, et al. Correlation of immunological studies and disease progression in chronic progressive multiple sclerosis. Ann Neurol1989;25:172-78.
29.
Sand T., Sulg IAEvoked potentials and CSF-immunoglobulins in MS: relationship to disease duration, disability, and functional status. Acta Neurol Scand1990 ;82:217-21.
30.
Granger C., Cotter A., Hamilton B., Fiedler R., Hens M.Functional assessment scales: a study of persons with multiple sclerosis. Arch Phys Med Rehabil1990;71:870-75.
31.
Francis D., Bain P., Swan A., Hughes R.An assessment of disability rating scales used in multiple sclerosis. Arch Neurol1991;48:299-301.
32.
Verdier-Taillefer MH, Zuber M., Lyon-Caen O., Clanet M., Gout O., Louis C., Alperovitch A.Observer disagreement in rating neurologic impairment in multiple sclerosis: facts and consequences. Eur Neurol1991;31:117-19.
33.
Goodkin DE, Cookfair D., Wende K., Bourdette D., Pullicino P., Scherokman B., Whitham R.Multiple Sclerosis Collaborative Research Group. Inter- and intrarater scoring agreement using grades 1.0 to 3.5 of the Kurtzke Expanded Disability Status Scale (EDSS). Neurology1992;42:859-63.
34.
Goodman TL, Hicks RWComparison of disability status and exercise performance in patients with multiple sclerosis. Med & Sci in Sports and Exercise1993;25(suppl):S44.
