The aim of this study was to determine the risk of having significant depressive symptoms in subjects with obesity and type 2 diabetes mellitus through a meta-analysis. Our results showed that individuals with obesity and diabetes have an increased risk of having significant symptoms of depression. In subgroup analyses, we observed that Caucasian populations have an increased risk of having these symptoms. Our meta-analysis suggests that obesity is associated with an increased risk of having significant depressive symptoms in patients with type 2 diabetes, and they could be even higher in Caucasian populations.
AbubakariARBhopalRS (2008) Systematic review on the prevalence of diabetes, overweight/obesity and physical inactivity in Ghanaians and Nigerians. Public Health122: 173–182.
2.
AndersonRJFreedlandKEClouseRE, et al. (2001) The prevalence of comorbid depression in adults with diabetes: A meta-analysis. Diabetes Care24: 1069–1078.
3.
AtlantisE (2012) Obesity and increased risk of type 2 diabetes mellitus: The aetiological role of depression. Obesity Research & Clinical Practice6: e175–e262.
4.
BelmakerRHAgamG (2008) Major depressive disorder. The New England Journal of Medicine358: 55–68.
5.
BlaineB (2008) Does depression cause obesity? A meta-analysis of longitudinal studies of depression and weight control. Journal of Health Psychology13: 1190–1197.
6.
BlazerDGMoody-AyersSCraft-MorganJ, et al. (2002) Depression in diabetes and obesity: Racial/ethnic/gender issues in older adults. Journal of Psychosomatic Research53: 913–916.
7.
CalvínJRGaviriaAZRíosMM (2015) Prevalence of depression in type 2 diabetes mellitus. Revista Clínica Española215: 156–164.
8.
ChiodiniITorlontanoMScillitaniA, et al. (2005) Association of subclinical hypercortisolism with type 2 diabetes mellitus: A case-control study in hospitalized patients. European Journal of Endocrinology153: 837–844.
9.
Cols-SagarraCLopez-SimarroFAlonso-FernandezM, et al. (2016) Prevalence of depression in patients with type 2 diabetes attended in primary care in Spain. Primary Care Diabetes10: 369–375.
10.
El-ShafieTMEl-SaghierEOARamadanIK (2011) Depression among type 2 diabetic patients. The Egyptian Journal of Hospital Medicine44: 258–271.
11.
EversonSAMatySCLynchJW, et al. (2002) Epidemiologic evidence for the relation between socioeconomic status and depression, obesity, and diabetes. Journal of Psychosomatic Research53: 891–895.
12.
FerchakCVMeneghiniLF (2004) Obesity, bariatric surgery and type 2 diabetes: A systematic review. Diabetes/Metabolism Research and Reviews20: 438–445.
13.
GuruprasadKGNiranjanMRAshwinS (2012) A study of association of depressive symptoms among the type 2 diabetic outpatients presenting to a tertiary care hospital. Indian Journal of Psychological Medicine34: 30–33.
14.
HabtewoldTDAlemuSMHaileYG (2016) Sociodemographic, clinical, and psychosocial factors associated with depression among type 2 diabetic outpatients in Black Lion General Specialized Hospital, Addis Ababa, Ethiopia: A cross-sectional study. BMC Psychiatry16: 103.
15.
HigginsTSJrRitchieCSStetsonBA, et al. (2007) An examination of the moderating effect of treatment with anti-depressants on the association of heart disease with depression in males with type 2 diabetes attending a Veterans Affairs Medical Center. Diabetes Research and Clinical Practice75: 220–228.
16.
IslamSMRawalLBNiessenLW (2015) Prevalence of depression and its associated factors in patients with type 2 diabetes: A cross-sectional study in Dhaka, Bangladesh. Asian Journal of Psychiatry17: 36–41.
17.
JainASharmaRChoudharyPK, et al. (2015) Study of fatigue, depression, and associated factors in type 2 diabetes mellitus in industrial workers. Indian Journal of Psychiatry24: 179–184.
18.
Kamrul-HasanABPalash-MollaMMainul-AhsanM, et al. (2019) Prevalence and predictors of depression among patients with type 2 diabetes: A multicenter cross-sectional study from Bangladesh. Mymensingh Medical Journal28: 23–30.
19.
KatonWvon KorffMCiechanowskiP, et al. (2004) Behavioral and clinical factors associated with depression among individuals with diabetes. Diabetes Care27: 914–920.
20.
KesslerRCBerglundPDemlerO, et al. (2003) The epidemiology of major depressive disorder: Results from the National Comorbidity Survey Replication (NCS-R). JAMA289: 3095–3105.
21.
KhalediMHaghighatdoostFFeiziA, et al. (2019) The prevalence of comorbid depression in patients with type 2 diabetes: An updated systematic review and meta-analysis on huge number of observational studies. Acta Diabetologica56: 631–650.
22.
KimuraYSugaHKobayashiS, et al. (2020) Intake of coffee associated with decreased depressive symptoms among elderly Japanese women: A multi-center cross-sectional study. Journal of Epidemiology30: 338–344. DOI: 10.2188/jea.JE20190010.
23.
KrzysztoszekJLaudanska-KrzeminskaIBronikowskiM (2019) Assessment of epidemiological obesity among adults in EU countries. Annals of Agricultural and Environmental Medicine26: 341–349.
24.
LabadJPriceJStrachanM, et al. (2010) Symptoms of depression but not anxiety are associated with central obesity and cardiovascular disease in people with type 2 diabetes: The Edinburgh Type 2 Diabetes Study. Diabetologia53: 467–471.
25.
Lara Munoz MdelCJacobsEAEscamillaMA, et al. (2014) Depression among diabetic women in urban centers in Mexico and the United States of America: A comparative study. Revista Panamericana de Salud Pública36: 225–231.
26.
LeoneTCoastENarayananS, et al. (2012) Diabetes and depression comorbidity and socio-economic status in low and middle income countries (LMICs): A mapping of the evidence. Global Health8: 39.
27.
LoCKMertzDLoebM (2014) Newcastle-Ottawa Scale: Comparing reviewers’ to authors’ assessments. BMC Medical Research Methodology14: 45.
MelinEOThunanderMLandin-OlssonM, et al. (2017) Depression differed by midnight cortisol secretion, alexithymia and anxiety between diabetes types: A cross sectional comparison. BMC Psychiatry17: 335.
30.
MezukBEatonWWAlbrechtS, et al. (2008) Depression and type 2 diabetes over the lifespan: A meta-analysis. Diabetes Care31: 2383–2390.
31.
MirghaniHOElbadawiAS (2016) Depression, anxiety, and daytime sleepiness among type 2 diabetic patients and their correlation with the diabetes control: A case-control study. Journal of Taibah University Medical Sciences11: 374–379.
32.
MurrayCJVosTLozanoR, et al. (2012) Disability-adjusted life years (DALYs) for 291 diseases and injuries in 21 regions, 1990-2010: A systematic analysis for the Global Burden of Disease Study 2010. The Lancet380: 2197–2223.
33.
NasserJHabibFHasanM, et al. (2009) Prevalence of depression among people with diabetes attending diabetes clinics at primary health settings. Bahrain Medical Bulletin31: 1–7.
34.
NestlerEJBarrotMDiLeoneRJ, et al. (2002) Neurobiology of depression. Neuron34: 13–25.
35.
NouwenALloydCEPouwerF (2009) Depression and type 2 diabetes over the lifespan: A meta—analysis—Response to Mezuk et al. Diabetes Care32: e56; author reply e57.
36.
ParkCYKimSYGilJW, et al. (2015) Depression among Korean adults with type 2 diabetes mellitus: Ansan-community-based epidemiological study. Osong Public Health and Research Perspectives6: 224–232.
37.
Pereira-MirandaECostaPRFQueirozVAO, et al. (2017) Overweight and obesity associated with higher depression prevalence in adults: A systematic review and meta-analysis. Journal of the American College of Nutrition36: 223–233.
38.
PrinzNEbnerSGrünerbelA, et al. (2017) Female sex, young age, northern German residence, hypoglycemia and disabling diabetes complications are associated with depressed mood in the WHO-5 questionnaire: A multicenter DPV study among 17,563 adult patients with type 2 diabetes. Journal of Affective Disorders208: 384–391.
39.
ResnickHEValsaniaPHalterJB, et al. (1998) Differential effects of BMI on diabetes risk among black and white Americans. Diabetes Care21: 1828–1835.
40.
RoupaZKoulouriASotiropoulouP, et al. (2009) Anxiety and depression in patients with type 2 diabetes mellitus, depending on sex and body mass index. Health Science Journal3: 32–40.
41.
SaccoWPWellsKJVaughanCA, et al. (2005) Depression in adults with type 2 diabetes: The role of adherence, body mass index, and self-efficacy. Health Psychology24: 630–634.
42.
Sevilla-GonzalezMDRQuintana-MendozaBMAguilar-SalinasCA (2017) Interaction between depression, obesity, and type 2 diabetes: A complex picture. Archives of Medical Research48: 582–591.
43.
SinghHRajuMSDubeyV, et al. (2014) A study of sociodemographic clinical and glycemic control factors associated with co-morbid depression in type 2 diabetes mellitus. Indian Journal of Psychiatry23: 134–142.
44.
SmithKJSchmitzN (2014) Association of depression and anxiety symptoms with functional disability and disability days in a community sample with type 2 diabetes. Psychosomatics55: 659–667.
45.
StangA (2010) Critical evaluation of the Newcastle-Ottawa scale for the assessment of the quality of nonrandomized studies in meta-analyses. European Journal of Epidemiology25: 603–605.
46.
StrachanMWReynoldsRMMarioniRE, et al. (2011) Cognitive function, dementia and type 2 diabetes mellitus in the elderly. Nature Reviews Endocrinology7: 108–114.
47.
StuartMJBauneBT (2012) Depression and type 2 diabetes: Inflammatory mechanisms of a psychoneuroendocrine co-morbidity. Neuroscience & Biobehavioral Reviews36: 658–676.
48.
SughraUImranM (2018) Co-morbid depression in individuals with type 2 diabetes mellitus. Journal of Pakistan Medical Association68: 109–111.
49.
SvenningssonIBjorkelundCMarklundB, et al. (2012) Anxiety and depression in obese and normal-weight individuals with diabetes type 2: A gender perspective. Scandinavian Journal of Caring Sciences26: 349–354.
50.
SweilehWMAbu-HadeedHMAl-JabiSW, et al. (2014) Prevalence of depression among people with type 2 diabetes mellitus: A cross sectional study in Palestine. BMC Public Health14: 163.
51.
Tellez-ZentenoJFCardielMH (2002) Risk factors associated with depression in patients with type 2 diabetes mellitus. Archives of Medical Research33: 53–60.
52.
Tovilla-ZarateCJuarez-RojopIPeralta JimenezY, et al. (2012) Prevalence of anxiety and depression among outpatients with type 2 diabetes in the Mexican population. PLoS ONE7: e36887.
53.
TsenkovaVKKarlamanglaA (2016) Depression amplifies the influence of central obesity on 10-year incidence of diabetes: Findings from MIDUS. PLoS ONE11: e0164802.
54.
TsigosCChrousosGP (2002) Hypothalamic–pituitary–adrenal axis, neuroendocrine factors and stress. Journal of Psychosomatic Research53: 865–871.
55.
WaitzfelderBGerzoffRBKarterAJ, et al. (2010) Correlates of depression among people with diabetes: The Translating Research Into Action for Diabetes (TRIAD) study. Primary Care Diabetes4: 215–222.
56.
WangYLopezJMBolgeSC, et al. (2016) Depression among people with type 2 diabetes mellitus, US National Health and Nutrition Examination Survey (NHANES), 2005-2012. BMC Psychiatry16: 88.
57.
WangYYangHNolanM, et al. (2018) Association of depression with evolution of heart failure in patients with type 2 diabetes mellitus. Cardiovascular Diabetology17: 19.
58.
WooYSSeoHJMcIntyreRS, et al. (2016) Obesity and its potential effects on antidepressant treatment outcomes in patients with depressive disorders: A literature review. International Journal of Molecular Sciences17: 80.
59.
YuMZhangXLuF, et al. (2015) Depression and risk for diabetes: A meta-analysis. Canadian Journal of Diabetes39: 266–272.
60.
ZhouJXLiHCBaiXJ, et al. (2013) Functional Val66Met polymorphism of brain-derived neurotrophic factor in type 2 diabetes with depression in Han Chinese subjects. Behavioral and Brain Functions9: 34.
61.
ZuberiSISyedEUBhattiJA (2011) Association of depression with treatment outcomes in type 2 diabetes mellitus: A cross-sectional study from Karachi, Pakistan. BMC Psychiatry11: 27.
