Synthetic and to a lesser extent vein graft failure is still a major problem in the treatment of peripheral arterial disease, with neointimal hyperplasia being the main cause for graft occlusion in the medium and long term. This review aims to establish the current status of external stents or sheaths in the prevention of intimal hyperplasia in small diameter (< 6 mm) vein grafts.
Favaloro RGCritical analysis of coronary artery bypass graft surgery: a 30 year journey . J Am Coll Cardiol1998; 31 (4 suppl B): 1B-63B.
2.
Angelini GD, Newby ACThe future of saphenous vein as a coronary artery bypass conduit. Eur Heart J1989; 10: 273-280.
3.
Mehta D., Izzat MB, Bryan AJ, Angelini GDTowards the prevention of vein graft failure. Int J Cardiol1997; 62(suppl 1): S55-S63.
4.
Bhan A., Gupta V., Choudhary SK, et al. Radial artery in CABG: could the early results be comparable to internal mammary artery graft?Ann Thorac Surg1999; 67: 1631-1636.
5.
Jackson MR, Belott TP, Dickeson T., Kaiser WJ, Modrall JG, Valentine RJThe consequences of a failed femoropopliteal bypass grafting: comparison of saphenous vein and PTFE graft. J Vasc Surg2000; 32: 498-505.
6.
Tangelder MJ , Algra A., Lawson JA, Eikelboom BCRisk factors for occlusion of infrainguinal bypass grafts. Eur J Vasc Endovasc Surg2000 ; 20: 118-124.
7.
Veith FJ, Gupta SK, Ascer E., et al. Six-year prospective multicenter randomized comparison of autologous saphenous vein and expanded polytetrafluoroethylene grafts in infrainguinal arterial reconstructions. J Vasc Surg1986 ; 3: 104-114.
Neitzel GF, Barboriak JJ, Pintar K.Atherosclerosis in aortocoronary bypass grafts. Morphological study and risk factor analysis 6 to 12 years after surgery. Arteriosclerosis1986; 6: 594-600.
10.
Scwartz SM, deBlois D., O’Brien ERM.The neointima: soil for atherosclerosis and restenosis. Circ Res1996; 77: 445-465.
Sarkar S., Salacinski HJ, Hamilton G., Seifalian AMThe mechanical properties of infrainguinal vascular bypass grafts: their role in influencing patency. Eur J Vasc Endovasc Surg2006; 31: 627-636.
13.
Tennant M., Dilley RJ, McGeachie JK, Prendergast FJThe histogenesis of intimal hyperplasia and atherosclerosis. Aust N Z J Surg1990; 60: 79-85.
14.
Dilley RJ, McGeachie JK, Prendergast FJA review of the histologic changes in vein to artery grafts with particular reference to intimal hyperplasia. Arch Surg1988; 123: 691-696.
15.
Thatte HS, Khuri SFThe coronary artery bypass conduit: intraoperative endothelial injury and its implication on graft patency. Ann Thorac Surg2001; 72: S2245-2252.
16.
Eslami MH, Gangadharan SP, Belkin M.Monocyte adhesion to human vein grafts: a marker for occult intraoperative injury?J Vasc Surg2001; 34: 923-929.
17.
Jeremy JY, Mehta D., Bryan AJ, Angelini GDPlatelets and saphenous vein graft failure. Platelets1997; 8: 295-309.
18.
Ehsan A., Mann MJ, Dell’Acqua G.Endothelial healing in vein grafts: proliferative burst unimpaired by genetic therapy of neointimal disease. Circulation2002; 105: 1686-1692.
19.
Powell JT, Gosling M.Molecular and cellular changes in vein grafts: influence of pulsatile stretch . Curr Opin Cardiol1998; 13: 453-458.
20.
Holt CM, Francis SE, Newby AC, et al. Comparison of response to injury in organ culture of human saphenous vein and internal mammary artery. Ann Thorac Surg1993; 55: 1522-1528.
21.
Dobrin PB, Littoy FN, Endean EDMechanical factors predisposing to intimal hyperplasia and medial thickening in autogenous vein grafts. Surgery1989; 105: 393-400.
22.
Tiwari A., Cheng KS, Salacinski H., Hamilton G., Seifalian AMImproving the patency of vascular bypass grafts: the role of suture materials and surgical techniques on reducing anastomotic compliance mismatch . Eur J Vasc Endovasc Surg2003; 25: 287-295.
23.
Davies MG, Hagen POPathophysiology of vein graft failure: a review. Eur J Vasc Endovasc Surg1995; 9: 7-18.
24.
Muzaffar S. , Shukla N., Angelini GD, Jeremy JYHypoxia and the expression of gp91phox and endothelial nitric oxide synthase in the pulmonary artery. Thorax2005; 60: 305-313.
25.
Shi Y., O’Brien JE Jr , Mannion JD, et al. Remodeling of autologous saphenous vein grafts. The role of perivascular myofibroblasts. Circulation1997; 95: 2684-2693.
Aplin AE, Howe A., Alahari SKSignal transduction and signal modulation by cell adhesion receptors: the role of integrins, cadherins, immunoglobulin-cell adhesion molecules, and selectins. Pharmacol Rev1998; 50: 197-263.
28.
Chester AH, Morrison KJ, Yacourb MHExpression of vascular adhesion molecules in saphenous vein coronary artery bypass grafts. Ann Thorac Surg1998 ; 65: 1685-1689.
29.
Alrawi SJ, Samee M., Raju R.Intercellular and vascular cell adhesion molecule levels in endoscopic and open saphenous vein harvesting for coronary artery bypass graft surgery . Heart Surg Forum2000; 3: 241-245.
30.
Van der Wal AC, Becker AE, Elbers JRAn immunocytochemical analysis of rapidly progressive atherosclerosis in human vein grafts. Eur J Cardiothorac Surg1992; 6: 469-473.
31.
Fitzgibbon GM, Kafka HP, Leach AJ, Keon WJ, Hooper GD, Burton JRCoronary bypass graft fate and patient outcome: angiographic follow up of 5063 grafts related to survival and reoperation in 1388 patients during 25 years. J Am Coll Cardiol1999; 28: 616-626.
32.
Wong AP, Nili N., Jackson ZS, et al. Expansive remodeling in venous bypass grafts: novel implications for vein graft disease. Atherosclerosis2008 ; 196: 580-589.
33.
Owens CD, Wake N., Jacot JG, et al. Early biomechanical changes in lower extremity vein grafts - distinct temporal phases of remodeling and wall stiffness. J Vasc Surg2006; 44: 740-746.
34.
Yamanouchi D., Banno H., Nakayama M., et al. Hydrophilic statin suppresses vein graft intimal hyperplasia via endothelial cell-tropic Rho-kinase inhibition . J Vasc Surg2005;42:757-764.
35.
Israel DH, Adams PC, Stein B., Chesebro JH, Fuster V.Antithrombotic therapy in the coronary vein graft patient. Clin Cardiol1991; 14: 283-295.
36.
Xiao F., Zhang LF, Shi ZH[Administration of sirolimus affects vein graft neointima hyperplasia.]Beijing Da Xue Xue Bao2006; 38: 515-518.
37.
Knatterud GL , Rosenberg Y., Campeau L., et al. Long-term effects on clinical outcomes of aggressive lowering of low-density lipoprotein cholesterol levels and low-dose anticoagulation in the post coronary artery bypass graft trial. Post CABG Investigators. Circulation2000; 102: 157-165.
38.
Campeau L., Hunninghake DB, Knatterud GL, et al. Aggressive cholesterol lowering delays saphenous vein graft atherosclerosis in women, the elderly, and patients with associated risk factors. NHLBI post coronary artery bypass graft clinical trial. Post CABG Trial Investigators . Circulation1999; 99: 3241-3247.
39.
Kohler TR, Kaufman JL, Kacoyanis G., et al. Effect of aspirin and dipyridamole on the patency of lower extremity bypass grafts. Surgery1984; 96: 462-466.
40.
Dorffler-Melly J., Buller HR, Koopman MM, Prins MHAntithrombotic agents for preventing thrombosis after infrainguinal arterial bypass surgery . Cochrane Database Syst Rev2003; CD000536.
41.
Goldman S., Copeland J., Moritz T., et al. Long-term graft patency (3 years) after coronary artery surgery. Effects of aspirin: results of a VA Cooperative study. Circulation1994; 89: 1138-1143.
42.
Schwartz RS , Koval TM, Edwards WD, et al. Effect of external beam irradiation on neointimal hyperplasia after experimental coronary artery injury. J Am Coll Cardiol1992; 19: 1106-1113.
43.
Wiedermann JG, Marboe C., Amols H., Schwartz A., Weinberger J.Intracoronary irradiation markedly reduces restenosis after balloon angioplasty in a porcine model. J Am Coll Cardiol1994; 23: 1491-1498.
44.
Trerotola SO , Carmody TJ, Timmerman RD, et al. Brachytherapy for the prevention of stenosis in a canine hemodialysis graft model: preliminary observations. Radiology1999; 212: 748-754.
45.
Costa RFB , Fagundes DJ, Juliano Y., Novo NF, Vieira WTTEffects of external gamma radiation on femoral artery reimplantation in rats . Morphometrical analyzes. Acta Cir Bras2003 ; 18(2): 86-96.
46.
Mann MJ, Whittemore AD, Donaldson MC, et al. Ex-vivo gene therapy of human vascular bypass grafts with E2F decoy: the PREVENT single-centre, randomised, controlled trial. Lancet1999; 354: 1493-1498.
47.
Grube E.Project of Ex-vivo Vein Graft Engineering via Transfection (PREVENT) II trial . Presented at the American Heart Association Scientific Sessions; November 11-14, 2001; Anaheim, CA , USA.
48.
Conte MS, Bandyk DF, Clowes AW, et al; PREVENT III Investigators.Results of PREVENT III: a multicenter, randomized trial of edifoligide for the prevention of vein graft failure in lower extremity bypass surgery . J Vasc Surg2006; 43: 742-751.
49.
Alexander JH , Hafley G., Harrington RA, et al; PREVENT IV Investigators.Efficacy and safety of edifoligide, an E2F transcription factor decoy, for prevention of vein graft failure following coronary artery bypass graft surgery: PREVENT IV: a randomized controlled trial. JAMA2005; 294: 2446-2454.
50.
Sayers RD, Watt PA, Muller S., Bell PR, Thurston H.Endothelial cell injury secondary to surgical preparation of reversed and in situ saphenous vein bypass grafts. Eur J Vasc Surg1992;6:354-361.
51.
Jeremy JY, Gadsdon P., Shukla N., et al. On the biology of saphenous vein grafts fitted with external sheaths and stents. Biomaterials2007; 28: 895-908.
52.
Parsonnet VAA , Lari AA, Shah IHNew stent for support of veins in arterial grafts. Arch Surg1963 ; 87: 696-702.
53.
Karayannacos PE, Hostetler JR, Bond MG, Kakos GS, Williams RA, Kilman JWLate failure in vein grafts: mediating factors in subendothelial fibromuscular hyperplasia . Ann Surg1978; 187: 83-88.
54.
Mehta D., George SJ, Jeremy JY, Izzat MB, Southgate KM, Bryan AJExternal stenting reduces long-term medial and neointimal thickening and platelet derived growth factor expression in a pig model of arteriovenous bypass grafting . Nat Med1998; 4: 235-239.
55.
Teng Z., Ji G., Chu H., et al. Does PGA external stenting reduce compliance mismatch in venous grafts?Biomed Eng Online2007; 6: 1-11.
56.
Bambang LS, Moczar M., Lecerf L., Loisance D.External biodegradable supporting conduit protects endothelium in vein graft in arterial interposition. Int J Artif Organs1997; 20: 397-406.
57.
Kohler TR, Kirkman TR, Clowes AWThe effect of rigid external support on vein graft adaptation to the arterial circulation. J Vasc Surg1989; 9: 277-285.
58.
Batellier J. , Wassef M., Merval R., Duriez M., Tedgui A.Protection from atherosclerosis in vein grafts by a rigid external support . Arterioscler Thromb1993; 13: 379-384.
59.
Sottlurai VS , Yao JS, Batson RC, Sue SL, Jones R., Nakamura YADistal anastomotic intimal hyperplasia: histopathologic character and biogenesis. Ann Vasc Surg1989 ; 3: 26-33.
60.
Angelini GD , Bryan AJ, Williams HM, Morgan R., Newby ACDistention promotes platelet and leukocyte adhesion and reduces short-term patency in pig arteriovenous bypass grafts . J Thorac Cardiovasc Surg1990; 99: 433-439.
61.
Bassiouny HS , White S., Glagov S., Choi E., Giddens DP, Zarins CKAnastomotic intimal hyperplasia: mechanical injury or flow induced. J Vasc Surg1992; 15: 708-717.
62.
White SS, Zarins CK, Giddens DP, Bassiouny H., Loth F., Jones SAHemodynamic patterns in two models of end-to-side vascular graft anastomoses: effects of pulsatility, flow division, Reynolds number, and hood length. J Biomech Eng1993; 115: 104-111.
63.
Liu SQ, Moore MM, Glucksberg MR, Mockros LF, Grotberg JB, Mok APPartial prevention of monocyte and granulocyte activation in experimental vein grafts by using a biomechanical engineering approach. J Biomech1999; 32: 1165-1175.
64.
O’Brien JE Jr, Ormont ML, Shi YI, Wang D., Zalewski A., Mannion JDEarly injury to the medial after saphenous vein grafting. Ann Thorac Surg1998; 65: 1273-1278.
65.
Mayr M., Li C., Zou Y., Heumer U., Hu Y., Xu Q.Biomechanical stress-induced apoptosis in vein graft involves p38 mitogen-activated protein kinases. FASEB J2000; 15: 261-270.
66.
Vijayan V., Shukla N., Johnson JL, et al. Long-term reduction of medial and intimal thickening in porcine saphenous vein grafts with a polyglactin biodegradable external sheath. J Vasc Surg2004; 40: 1011-1019.
67.
Jeremy JY, Bulbulia R., Johnson JL, et al. A bioabsorbable (polyglactin), nonrestrictive, external sheath inhibits porcine saphenous vein graft thickening. J Thorac Cardiovasc Surg2004; 127: 1766-1772.
68.
Hynes N., Mahendran B., Tawfik S., Sultan S.Reinforced long saphenous vein bypass graft for infrainguinal reconstruction procedures: case series and review of literature. Vascular2006; 14: 113-118.
69.
Barra JA, Volant A., Leroy JP, et al. Constrictive perivenous mesh prosthesis for preservation of vein integrity. Experimental results and application for coronary bypass grafting . J Thorac Cardiovasc Surg1986; 92(3 Pt 1): 330-336.
70.
Trubel W., Moritz A., Schima H., et al. Compliance and formation of distal anastomotic intimal hyperplasia in Dacron mesh tube constricted veins used as arterial bypass grafts. ASAIO J1994; 40: M273-278.
71.
Moritz A., Raderer F., Magometschnigg H., Trubel W., Ullrich R., Laufer G., Staudacher M.The use of mesh-tube-constricted or dilated varicose veins as arterial bypass conduit. Thorac Cardiovasc Surg1992 ; 40: 356-360.
72.
Neufang A., Dorweiler B., Espinola-Klein C., et al. External reinforcement of varicose veins with PTFE prosthesis in infrainguinal bypass surgery - clinical results. Thorac Cardiovasc Surg2003; 51: 62-66.
73.
George SJ, Izzat MB, Gadsdon P., et al. Macro-porosity is necessary for the reduction of neointimal and medial thickening by external stenting of porcine saphenous vein bypass grafts. Atherosclerosis2001; 155: 329-336.
74.
Caro C., Jeremy J., Watkins N., et al. The geometry of unstented and stented pig common carotid artery bypass grafts. Biorheology2002; 39: 507-512.
75.
Zilla P., Human P., Wolf M., et al. Constrictive external nitinol meshes inhibit vein graft intimal hyperplasia in nonhuman primates. J Thorac Cardiovasc Surg2008; 136: 717-725.
76.
Kawatsu S., Oda K., Saiki Y., Tabata Y., Tabayashi K.External application of rapamycin-eluting film at anastomotic sites inhibits neointimal hyperplasia in a canine model. Ann Thorac Surg2007; 84: 560-567.
77.
Zou RJ, Zou LJ, Huang SD, et al. Effect of external stents on prevention of intimal hyperplasia in a canine vein graft model. Chin Med J2007 ; 120: 2264-2267.
78.
Bahcivan M. , Yucel S., Kefeli M., Gol MK, Can B., Keceligil HTInhibition of vein graft intimal hyperplasia by periadventitial application of hyaluronic acid-carboxymethyl cellulose: an experimental study. Scand Cardiovasc J2008; 42: 161-165.
79.
Zilla P., Wolf M., Rafiee N., et al. Utilization of shape memory in external vein-graft meshes allows extreme diameter constriction for suppressing intimal hyperplasia: a nonhuman primate study. J Vasc Surg2009; 49: 1532-1542.
80.
El-Kurdi MS , Hong Y., Stankus JJ, Soletti L., Wagner WR, Vorp DATransient elastic support for vein grafts using a constricting microfibrillar polymer wrap. Biomaterials2008; 29: 3213-3220.
81.
Zurbrugg HR , Wied M., Angelini GD, Hetzer R.Reduction of intimal and medial thickening in sheathed vein grafts. Ann Thorac Surg1999 ; 68: 79-83.
82.
Krejca M., Skarysz J., Szmagala P., et al. A new outside stent - does it prevent vein graft intimal proliferation?Eur J Cardiothorac Surg2002; 22: 898-903.
83.
Angelini GD , Lloyd C., Bush R., Johnson J., Newby ACAn external, oversized, porous polyester stent reduces vein graft neointima formation, cholesterol concentration, and vascular cell adhesion molecule 1 expression in cholesterol-fed pigs. J Thorac Cardiovasc Surg2002; 124: 950-956.
84.
Sterpetti AVShear stress influences the release of platelet derived growth factor and basic fibroblast growth factor by arterial smooth muscle cells. Eur J Vasc Endovasc Surg1994 ; 8: 138-142.
85.
Sumpio BE, Banes AJResponse of porcine aortic smooth muscle cells to cyclic tensional deformation in culture. J Surg Res1988; 44: 696-701.
86.
Zwolak RM, Adams MC, Clowes AWKinetics of vein graft hyperplasia: association with tangential stress . J Vasc Surg1987; 5: 126-136.
Mattsson EJ , Kohler Trvsm, Clowes AWIncreased blood flow induces regression of neointimal hyperplasia. Arterioscler Thromb Vasc Biol1997; 17: 2245-2249.
89.
Vijayan V., Smith FC, Angelini GD, Bulbulia RA, Jeremy JYExternal supports and the prevention of neointima formation in vein grafts . Eur J Vasc Endovasc Surg2002; 24: 13-22.
90.
Izzat MB, Mehta D., Bryan AJ, Reeves B., Newby AC, Angelini GDInfluence of external stent size on early medial and neointimal thickening in a pig model of saphenous vein bypass grafting. Circulation1996; 94: 1741-1745.
91.
Moritz A., Grabenwoger F., Raderer F., et al. Mesh tube-constricted varicose veins used as bypass grafts for infrainguinal arterial reconstruction. Arch Surg1992; 127: 416-420.
92.
Lardenoye JH , De Vries MR, Girmbergen JM, et al. Inhibition of accelerated atherosclerosis in vein grafts by placement of an external stent in ApoE*3-Leiden transgenic mice. Arterioscler Thromb Vasc Biol2002; 22: 1433-1438.
93.
Bakker SG, Talbert A., Cotram S., Baskerville PA, Martin JFArterial intimal hyperplasia after occlusion of the adventitial vasa vasorum in the pig. Arterioscler Thromb Vasc Biol1993; 13: 70-77.
94.
Nguyen HC, Grossi EA, LeBoutillier M., et al. Mammary artery versus saphenous vein grafts: assessment of basic fibroblast growth factor receptors. Ann Thorac Surg1994; 58: 308-310.
95.
Cox JL, Chiasson DA, Gotlieb AIStranger in a strange land: the pathogenesis of saphenous vein graft stenosis with emphasis on structural and functional differences between veins and arteries . Prog Cardiovasc Dis1991; 34: 45-68.
96.
Khurana R., Zhuang Z., Bhardwaj S., et al. Angiogenesisdependent and independent phases of intimal hyperplasia . Circulation2004; 110: 2436-2443.
97.
Trubel W., Schima H., Moritz A., et al. Compliance mismatch and formation of distal anastomotic intimal hyperplasia in externally stiffened and lumen-adapted venous grafts. Eur J Vasc Endovasc Surg1995; 10: 415-423.
98.
Moritz A., Magometschnigg H., Staudacher M., et al. [Use of prosthesis enclosed dilated or varicose veins as arterial bypass transplant.]Vasa Suppl1992; 37: 20.
99.
Moritz A., Magometschnigg H., Ptakovsky H., et al. Mesh-constricted varicose and dilated veins used as arterial bypass grafts. Int J Artif Organs1991; 14: 435-440.
100.
Moritz A., Magometschnigg H., Staudacher M., et al. [Stented dilated or varicose veins as arterial bypass transplants: experimental and initial clinical results.]Vasa1991; 20: 222-229.
101.
Battellier J., Tedgui A.Reduction of atherogenesis in an arterialized venous graft by using an external sleeve. Chirurgie1992; 118: 659-664.
102.
Stooker W. , Niessen HW, Baidoshvili A., et al. Perivenous support reduces early changes in human vein grafts: studies in whole blood perfused human vein segments . J Thorac Cardiovasc Surg2001; 121: 290-297.
103.
Violaris AG , Newbury AC, Angelini GDEffect of external stenting on wall thickening in arteriovenous bypass grafting. Ann Thorac Surg1993; 5: 667-671.
104.
Nakata Y., Shionoya S.Microcirculation and metabolism in the vascular wall concerned with the vasa vasorum. Jpn Circ J1973; 37: 217-227.
105.
Pounds LL, Montes-Walters M., Mayhall CG, et al. A changing pattern of infection after major vascular reconstructions . Vasc Endovascular Surg2005; 39: 511-517.
106.
Bunt T.Vascular graft infections: an update. Cardiovasc Surg2001; 9: 225-233.
107.
El-Kurdi MS , Hong Y., Stankus JJ, Soletti L., Wagner WR, Vorp DATransient elastic support for vein grafts using a constricting microfibrillar polymer wrap. Biomaterials2008; 29: 3213-3220.
108.
Wu J., Zhang C.Neointimal hyperplasia, vein graft remodeling, and long-term patency . Am J Physiol Heart Circ Physiol2009; 297: H1194-1195.
