Sex differences in the antithrombotic effectiveness of aspirin

Craven LL Prevention of coronary and cerebral thrombosis. Mississippi Valley Med J 1956; 78: 213-16.

Weiss HJ , Aledort LM , Kochwa S. The effect of salicylates on the haemostatic properties of platelets in man . J Clin Invest 1968; 47: 2169-80.

Harrison Mjg , Meadows J. , Ross Russell RW , Marshall J. Effect of aspirin in amaurosis fugax. Lancet 1971; ii: 743-44.

Mundall J. , Quintero P. , von Kaulla KN et al. Transient monocular blindness and increased platelet aggregability treated with aspirin - a case report. Neurology 1972; 22: 280-85.

Antiplatelet trialists' collaboration. Secondary prevention of vascular disease by prolonged antiplatelet treatment Br Med J 1988; 296: 320-31.

The Canadian cooperative study group. A randomised trial of aspirin and sulfinpyrazone in threatened stroke. N Engl J Med 1978; 299: 53-59.

Anonymous. Aspirin - effective in males threatened with stroke (Editorial). Stroke 1978; 9: 295-97.

Harris WH , Salzman EW , Athanasoulis CA et al. Aspirin prophylaxis of venous thromboembolism after total hip replacement. N Engl J Med 1977; 297: 1246-49.

Linos A. , Worthington JW , O'Fallen W. et al. Effect of aspirin on prevention of coronary and cerebrovascular disease in patients with rheumatoid arthritis. Mayo Clin Proc 1978; 53: 581-86.

Dyken ML Antiplatelet aggregating agents in transient ischemic attacks and the relationship of risk factors. In: Breddin K , Loew D , Uberla K et al. eds, Prophylaxis of venous, peripheral, cardiac and cerebral vascular diseases with acetylsalicylic acid, Stuttgart : F Schattauer Verlag, 1980: 141-48.

Fields WS , Lemak NA , Frankowski RF , Hardy RJ Controlled trial of aspirin in cerebral ischemia. Stroke 1977; 8: 301-16.

Fields WS , Lemak NA , Frankowski RF et al. Controlled trial of aspirin in cerebral ischaemia. Circulation 1980; 62: 90-96.

UK-TIA Study Group. United Kingdom transient ischaemic attack (UK-TIA) aspirin trial: interim results. Br Med J 1988; 296: 316-20.

Bousser M-G. , Escwege E. , Huguenau M. et al. AICLA controlled trial of aspirin and dipyridamole in the secondary prevention of atherothrombotic cerebral ischaemia . Stroke 1983; 14: 5-14.

Sorensen PS , Pedersen H. , Marquardsen J. et al. Acetylsalicylic acid and the prevention of stroke in patients with reversible cerebral ischaemic attacks. A Danish cooperative study. Stroke 1983; 14: 15-22.

The ESPS Group. The European Stroke Prevention Study (ESPS). Lancet 1987; ii: 1351-54.

A Swedish cooperative study. High dose acetylsalicylic acid after cerebral infarction. Stroke 1987; 18: 325-34.

Candelise L. , Landi G. , Perrone P. et al. A randomised trial of aspirin and sulfinpyrazone in patients with TIA stroke 1982; 13: 175-79.

Fields WS , Lemak NA , Frankowski RF , Hardy RJ Controlled trial of aspirin in cerebral ischaemia. Part II: Surgical group . Stroke 1978; 9: 309-19.

Kaegi A. , Pineo GF , Shimizu A. et al. The role of sulfinpyrazone in the prevention of arteriovenous shunt thrombosis. Circulation 1975 ; 52: 497-99.

Johnson M. , Ramey E. , Ramwell PW Androgen-mediated sensitivity in platelet aggregation Am J Physiol 1977 ; 232: H381-385.

Orchard MA , Botting JH The influence of sex hormones on rat platelet sensitivity to adenosine-diphosphate . Thromb Haemost 1981;46:496-99.

Morikawa M. , Kojima T. , Inoue M. , Tsuboi M. Sex difference in the effect of aspirin on rat platelet aggregation and arachidonic acid metabolism. Jpn J Pharmacol 1985; 37: 317-23.

Vessey MP , Mann JI Female sex hormones and thrombosis Br Med Bull 1978; 34: 157-62.

Poller L. Oral contraceptives, blood clotting and thrombosis. Br Med Bull 1978; 34: 151-56.

Elkeles RS , Hampton JR , Mitchell Jra. Effect of oestrogens on human platelet behaviour. Lancet 1968; ii: 315-18.

Johnson M. , Ramey E. , Ramwell PW Sex and age differences in human platelet aggregation. Nature 1975; 253: 355-57.

Pilo R. , Aharony D. , Raz A. Testosterone potentiation of lonophore and ADP induced platelet aggregation: relationship to arachidonic acid metabolism. Thromb Haemost 1981; 46: 538-42.

Harrison Mjg , Weisblatt E. A sex difference in the effect of aspirin on 'spontaneous' platelet aggregation in whole blood. Thromb Haemost 1983; 50: 773-74.

Brown P. , Harrison Mjg. The role of red blood cells in platelet aggregation in whole blood. Atherosclerosis 1988; 71: 261-62.

Weksler B. , Kent JL , Rudolph D. et al. Effects of low dose aspirin on platelet function in patients with recent cerebral ischaemia. Stroke 1985 ; 16: 5-9.

Kelton JS , Carter CJ , Rosenfeld J. et al. Sex-related differences in the efficacy of acetylsalicylic acid (ASA): the absorption of ASA and its effect on collagen-induced thromboxane B2 generation. Thromb Res 1981; 24: 163-68.

De la Cruz JP , Bellido I. , Camara S. et al. Effects of acetylsalicylic acid on platelet aggregation in male and female whole blood. Scand J Haematol 1986; 36: 394-97.

Escolar G. , Bastida E. , Garrido M. et al. Sex-related differences in the effects of aspirin on the interaction of platelets with subendothelium. Thromb Res 1986; 44: 837-47.

Spranger M. , Aspey BS , Harrison Mjg. Sex difference in antithrombotic effect of aspirin. Stroke 1989; 20: 34-37.

Uzunova A. , Ramey E. , Ramwell PW Effect of testosterone, sex, and age on experimentally induced arterial thrombosis . Nature 1976; 261: 712-13.

Gent M. , Blakely JA , Easton JD , and the CATS group. The Canadian American Ticlopidine Study (CATS) in thromboembolic stroke. Lancet 1989; i: 1215-20.

Kelton JG , Hirsh J. , Carter CJ , Buchanan MR Sex difference in the antithrombotic effects of aspirin. Blood: 1978; 52: 1073-76.