Magnetic resonance imaging detection of leptomeningeal enhancement has long been considered a red flag for a diagnosis of multiple sclerosis. However, recent studies seem to suggest that leptomeningeal enhancement can be detected in up to 25% of patients with multiple sclerosis. The case reported here suggest a distinct set of features of leptomeningeal enhancement in a patient with Susac’s syndrome which may still be helpful in the differential diagnosis between Susac’s syndrome and multiple sclerosis.
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