Abstract
Abnormal brain MRI has been described in up to 60% of patients with NMO patients. However, white matter T2 hyperintensities have been rarely observed. We report the case of a 49-year-old woman with long-lasting neuromyelitis optica (NMO) spectrum disorder and diffuse cerebral white matter T2-weighted hyperintensities. Our case suggests that some NMO patients can progressively develop l extensive cerebral involvement.
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References
1.
Wingerchuk
DM
Lennon
VA
Lucchinetti
CF
. The spectrum of neuromyelitis optica . Lancet Neurol 2007 ; 6 : 805 –815 .
2.
Wingerchuk
DM
Hogancamp
WF
O’Brien
PC
. The clinical course of neuromyelitis optica (Devic’s syndrome) . Neurology 1999 ; 53 : 1107 –1114 .
3.
Pittock
SJ
Lennon
VA
Krecke
K
. Brain abnormalities in neuromyelitis optica . Arch Neurol 2006 ; 63 : 390 –396 .
4.
de Seze
J
Blanc
F
Kremer
S
. Devic’s neuromyelitis optica: Clinical, laboratory, MRI and outcome profile . J Neurol Sci 2002 ; 197 : 57 –61 .
5.
Collongues
N
Marignier
R
Zéphir
H
. Neuromyelitis optica in France: A multicenter study of 125 patients . Neurology 2010 ; 74 : 736 –742 .
6.
Ito
S
Mori
M
Makino
T
. “Cloud-like enhancement” is a magnetic resonance imaging abnormality specific to neuromyelitis optica . Ann Neurol 2009 ; 66 : 425 –428 .
7.
Guimarães
J
Sá
MJ.
Devic disease with abnormal brain magnetic resonance image findings: The first Portuguese case . Arch Neurol 2007 ; 64 : 290 –291 .
