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Abstract

We studied repeated cerebrospinal fluids of patients with Devic’s neuromyelitis optica (NMO) and multiple sclerosis (MS). Variations of oligoclonal bands (OBs) had opposite trends in the two groups. In MS, O Bs were detected in 399 of 411 patients (97%) and never disappeared. In NMO, O Bs were detected in three of 11 patients (27%) and always disappeared. The hypothesis that NMO and MS follow distinct patho genetic pathways is supported by our findings, which can be useful for the differentiatio n of NMO from MS.

Keywords

cerebrospinal fluid Devic’s syndrome multiple sclerosis neuromyelitis optica oligoclonal bands

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Lucchinetti CF , Mandler RN , McGavern D , Bruck W , Gleich G , Ransohoff RM et al. A role for humoral mechanisms in the pathogenesis of Devic’s neuromyelitis optica . Brain 2002; 125: 1450-1461 .

Mandler RN , Davis LE , Jeffery DR , Kornfeld M. Devic’s neuromyelitis optica: a clinicopathologicalstudy of 8 patients . Ann Neurol 1993; 34: 162-168 .

Fazekas F , Offenbacher H , Schmidt R , Strasser-Fuchs S. MRI of neuromyelitis optica: evidence for a distinct entity . J Neurol Neurosurg Psychiatry 1994; 57: 1140-1142 .

Wingerchuk DM , Hogancamp WF , O’Brien PC , Weinshenker BG. The clinical course of neuromyelitis optica (Devic’s syndrome) . Neurology 1999; 53: 1107-1114 .

O’Riordan JI , Gallagher HL , Thompson AJ , Howard RS , Kingsley DP , Thompson EJ et al. Clinical, CSF, and MRI findings in Devic’s neuromyelitis optica . J Neurol Neurosurg Psychiatry 1996; 60: 382-387 .

Filippi M , Rocca MA , Moiola L , Martinelli V , Ghezzi A , Capra R et al. MRI and magnetization transfer imaging changes in the brain and cervical cord of patients with Devic’s neuromyelitis optica . Neurology 1999; 53: 1705-1710 .

De Seze J , Stojkovic T , Ferriby D , Gauvrit J-Y , Montagne C , Mounier-Vehier F et al. Devic’s neuromyelitis optica: clinical, laboratory, MRI and outcome profile . J Neurol Neurosurg Psychiatry 2002; 197: 57-61 .

Piccolo G , Franciotta DM , Camana C , Bergamaschi R , Banfi P , Sandrini G et al. Devic’s neuromyelitis optica: long term follow-up and serial CSF findings in two cases . J Neurol 1990; 237: 262-264 .

McLean BN , Luxton RW , Thompson EJ. A study of immunoglobulin G in the cerebrospinal fluid of 1007 patients with suspected neurological disease using isoelectric focusing and the Log IgG-Index. A comparison and diagnostic applications . Brain 1990; 113: 1269-1289 .

10.

Zeman AZ , Keir G , Luxton R , Thompson EJ. Serum oligoclonal IgG is a common and persistent finding in multiple sclerosis, and has a systemic source . QJM 1996; 89: 187-193 .

11.

McDonald WI , Compston A , Edan G , Goodkin D , Hartung HP , Lublin FD et al. Recommended diagnostic criteria for multiple sclerosis: guidelines from the International Panel on the diagnosis of multiple sclerosis . Ann Neurol 2001; 50: 121-127 .

12.

Tibbling G , Link H , Ohman S. Principles of albumin and IgG analysis in neurological disorders. I. Establishment of reference values . Scand J Clin Lab Invest 1977; 37: 385-390 .

13.

Farrell MA , Kaufmann JC , Gilbert JJ , Noseworthy JH , Armstrong HA , Ebers GC. Oligoclonal bands in multiple sclerosis: clinical-pathologic correlation . Neurology 1995; 35: 212-218 .

14.

Franciotta D , Piccolo G , Cuccia M , Bergamaschi R , Zardini E , Melzi d’Eril GV et al. Lack of both spinal fluid oligoclonal bands and complement 4A protein in an MS patient . Acta Neurol Scand 1994; 89: 72-74 .

15.

Gold R , Linington C. Devic’s disease: bridging the gap between laboratory and clinic . Brain 2002; 125: 1425-1427 .

Oligoclonal bands in Devic’s neuromyelitis optica and multiple sclerosis: differences in repeated cerebrospinal fluid examinations

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