We report on a so-far never described association between glomerulonephritis and sarcoid-like lung disease after long-term interferon beta (IFNb) treatment for relapsing–remitting multiple sclerosis. The interest in this case resides in the documented remission after IFNb discontinuation. The history of IFNb-related adverse events is probably not yet completely written. The rapid reversal of the pathological signs in our patient underlines the importance of careful clinical and laboratory surveillance, including kidney functional parameters, for an early diagnosis of IFNb-related diseases.
Bonaci-NikolicBJeremicIAndrejevicS. Anti-double stranded DNA and lupus syndrome induced by interferon-beta therapy in a patient with multiple sclerosis. Lupus2009; 18: 78–80.
2.
CarbonelliCMontepietraSCarusoA. Sarcoidosis and multiple sclerosis: Systemic toxicity associated with the use of interferon-beta therapy. Monaldi Arch Chest Dis2012; 77: 29–31.
3.
MarkowitzGSNasrSHStokesMB. Treatment with INF-α, -β or -γ is associated with collapsing focal segmental glomerulosclerosis. Clin J Am Soc Nephrol2010; 5: 607–615.
4.
OleaTDíaz-ManceboRPicazoML. Thrombotic microangiopathy associated with use of interferon-beta. Int J Nephrol Renovasc Dis2012; 5: 97–100.
5.
BroughtonACosynsJPJadoulM.Thrombotic microangiopathy induced by long-term interferon-β therapy for multiple sclerosis: A case report. Clin Nephrol2011; 76: 396–400.