Acute disseminated encephalomyelitis (ADEM) is a rare inflammatory demyelinating disease of the central nervous system, usually occurring after a vaccination or infectious disease. It has been exceptionally described in transplanted patients. The pathophysiology remains incompletely understood. We report the clinical, biological and magnetic resonance imaging (MRI) presentation and evolution of two kidney-transplanted patients with ADEM associated with local Epstein-Barr virus (EBV) reactivation. ADEM may occur in transplanted patients with favorable evolution. Its pathophysiology is uncertain, and the implication of EBV is discussed.
ReAGiachettiRAcute disseminated encephalomyelitis (ADEM) after autologous peripheral blood stem cell transplant for non-Hodgkin’s lymphoma. Bone Marrow Transplant1999; 24: 1351–1354.
6.
TomonariATojoAAdachiD. Acute disseminated encephalomyelitis (ADEM) after allogeneic bone marrow transplantation for acute myeloid leukemia. Ann Hematol2003; 82: 37–40.
7.
AuWYLieAKCheungRT. Acute disseminated encephalomyelitis after para-influenza infection post bone marrow transplantation. Leuk Lymphoma2002; 43: 455–457.
8.
AscherioAMungerKL99th Dahlem conference on infection, inflammation and chronic inflammatory disorders: Epstein-Barr virus and multiple sclerosis: Epidemiological evidence. Clin Exp Immunol2010; 160: 120–124.
9.
TzartosJSKhanGVossenkamperA. Association of innate immune activation with latent Epstein-Barr virus in active MS lesions. Neurology2012; 78: 15–23.
