Identifying reliable change in tactile temporal thresholds in multiple sclerosis: test-retest reliability

Abstract

Background Tactile temporal thresholds are typically significantly higher (ie, prolonged) in multiple sclerosis (MS) patients when compared to controls and increase significantly during relapses, probably reflecting integrity of conduction across a portion of the corpus callosum. As part of an ongoing validation study of tactile temporal thresholds, the test-retest reliability of these thresholds was examined in patients with MS.

Methods Tactile temporal thresholds were measured in 61 MS patients during two separate test sessions within three weeks. Test-retest reliability and the standard error of measurement were calculated. The threshold of change in tactile temporal thresholds in MS patients that would correspond to real change beyond measurement error with 95% certainty was also calculated.

Results The test-retest reliability of this measure of tactile temporal thresholds was 0.93. The threshold indicating change beyond chance or measurement error with 95% certainty was 19 ms.

Conclusions This measure of tactile temporal thresholds has excellent test - retest reliability and a change of greater than 19 ms is highly likely to represent real change. This measure is promising as a precise, reliable outcome measure in MS.

Keywords

measurement error multiple sclerosis outcome measure psychophysics reliable change tactile temporal processing test - retest reliability

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References

Kappos L , Moeri D , Radue EW , Schoetzau A , Schweikert K , Barkhof F et al. Predictive value of gadolinium-enhanced magnetic resonance imaging for relapse rate and changes in disability or impairment in multiple sclerosis: a meta-analysis . Lancet 1999; 353: 964-969 .

Caruana PA , Davies MB , Weatherby SJM , Williams R , Haq N , Foster DH et al. Correlation of MRI lesions with visual psychophysical deficit in secondary progressive multiple sclerosis . Brain 2000; 123: 1471-1480 .

Brown LN , Metz LM , Sainsbury RS. Sensory temporal thresholds and interhemispheric transfer times in multiple sclerosis: a preliminary study of a new outcome measure . J Clin Exp Neuropsychol 2003; 25: 783-792 .

Brown LN , Metz LM. Tactile temporal thresholds detect relapse-related changes in multiple sclerosis: a preliminary study . Mult Scler 2005; 11: 725-727 .

Daley ML , Swank RL , Ellison CM. Flicker fusion thresholds in multiple sclerosis: a functional measure of neurological damage . Arch Neurol 1979; 36: 292-295 .

Mason RJ , Snelgar RS , Foster DH , Heron JR , Jones RE. Abnormalities of chromatic and luminance critical flicker frequency in multiple sclerosis . Invest Ophthalmol Vis Sci 1982; 23: 246-252 .

Titcombe AF , Willison RG. Flicker fusion in multiple sclerosis . J Neurol Neurosurg Psychiatry 1961; 24: 260-266 .

Poser CM , Paty DW , Scheinberg L , McDonald I , Davis FA , Ebers GC et al. New diagnostic criteria for multiple sclerosis: guidelines for research protocols . Ann Neurol 1983; 13: 227-231 .

Bland JM , Altman DG. Measurement error . BMJ 1996; 313: 744-744 .

10.

Eliasziw M , Young SL , Woodbury MG , Fryday-Field K. Statistical methodology for the concurrent assessment of interrater and intrarater reliability: using goniometric measurements as an example . Phys Ther 1994; 74: 777-788 .

11.

Brown LN , Sainsbury RS. Hemispheric equivalence and age-related differences in judgments of simultaneity to somatosensory stimuli . J Clin Exp Neuropsychol 2000; 22: 587-598 .

12.

Rammsayer TH , Brandler S. On the relationship between general fluid intelligence and psychophysical indicators of temporal resolution , J Res Personality 2002; 36: 507-530 .