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Abstract

Tumor necrosis faaor-α (TNF-α), a proinflammatory cytokine, is believed to play an important role in multiple sclerosis (MS) pathogenesis. The objective of this study was to determine whether sequence variation in the TNF-α gene is associated with MS. Bi-allelic polymorphisms in the TNF-α promoter region (TNF-α −238 and −308) and microsatellite TNF-α were previously reported. We investigated these polymorphisms in 74 French patients with MS, compared with 75 controls. No significant differences regarding the TNF-α −238 and −308 polymorphisms were observed between MS patient and controls Allele frequency for the all allele is in very significant association (P < 0.0001) with MS, due in part to the assoiation of the all allele with the HLA-DRBI*15 allele in patients.

Keywords

multiple sclerosis (MS)tumor necrosis factor-α (TNF-α)TNF-α promoter polymorphisms −238 and −308 microsatellite TNF-α<HLA-DRBI*15 allele

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TNF-α polymorphisms in multiple sclerosis: no association with −238 and −308 promoter alleles,but the microsatellite allele all is associated with the disease in French patients

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