A review is presented of the recent progress made in mapping of the hereditary skin disease “Ferguson-Smith multiple self-healing squamous epithelioma.”
Methods:
The use of founder effects in an autosomal dominant disease is reviewed as applied to gene mapping efforts.
Results:
A common haplotype among Scottish families segregating Ferguson-Smith disease allowed the narrowing of the candidate gene interval and the identification of several possible disease-associated genes.
Conclusion:
The gene for Ferguson-Smith multiple self-healing squamous epithelioma lies in a narrow region on chromosome 9q, along with several other important hereditary skin disease loci.
Get full access to this article
View all access options for this article.
References
1.
SmithJ Ferguson. A case of multiple primary squamous-celled carcinomata of the skin in a young man, with spontaneous healing. Br J Dermatol1934; 46:267–272.
SybertVP. Genetic skin disorders. Oxford, UK: Oxford University Press, 1997:511–513.
4.
GoudieDRYuilleMALevershaMA. Multiple self-healing squamous epitheliomata (ESS1) mapped to chromosome 9q22-q31 in families with common ancestry. Nat Genet1993; 3:165–169.
5.
KingRCStansfieldWC. A dictionary of genetics. Oxford, UK: Oxford University Press, 1997:130.
6.
BaleSJ. When genetics gets under your skin. J Cutan Med Surg1996; 1:97–100.
7.
RichardsFBGoudieDRCooperTO. Mapping the multiple self-healing squamous epithelioma (MSSE) gene and investigation of xeroderma pigmentosum group A (XPA) and PATCHED (PTCH) as candidate genes. Hum Genet1997; 101:317–322.
8.
GailaniMRBaleSJLeffellDJ. Developmental defects in Gorlin syndrome related to a putative tumor suppressor gene on chromosome 9. Cell1992; 69:111–117.
