Fluorouracil is Superior to Other Commonly Used Topical Agents for the Treatment of Field Cancerization

Abstract

Keywords

actinic keratosis (AK)calcipotriol fluorouracil (5-FU)

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References

Jansen

MHE

Kessels

JPHM

Nelemans

et al . Randomized trial of four treatment approaches for actinic keratosis. N Engl J Med. 2019;380(10):935-946. doi:10.1056/NEJMoa1811850.

Calzavara-Pinton

Hædersdal

Barber

et al . Structured expert consensus on actinic keratosis: treatment algorithm focusing on daylight PDT. J Cutan Med Surg. 2017;21(1):3-16. doi:10.1177/1203475417702994.

Neugebauer

Zhu

et al . Comparative effectiveness of treatment of actinic keratosis with topical fluorouracil and imiquimod in the prevention of keratinocyte carcinoma: a cohort study. J Am Acad Dermatol. 2019;80(4):998-1005. doi:10.1016/j.jaad.2018.11.024.

Gupta

Paquet

. Network meta-analysis of the outcome ‘participant complete clearance’ in nonimmunosuppressed participants of eight interventions for actinic keratosis: a follow-up on a Cochrane review. Br J Dermatol. 2013;169(2):250-259. doi:10.1111/bjd.12343.

Cunningham

Tabacchi

Eliane

et al . Randomized trial of calcipotriol combined with 5-fluorouracil for skin cancer precursor immunotherapy. J Clin Invest. 2017;127(1):106-116. doi:10.1172/JCI89820.