We report a case of an 11-year-old female with Stevens-Johnson syndrome (SJS)/toxic epidermal necrolysis (TEN) overlap, most likely triggered by sulfamethoxazole-trimethoprim, who was treated with the combination of methylprednisolone, cyclosporine, and etanercept. Her condition stabilized and her skin involvement did not progress after the addition of etanercept. To our knowledge, this is the first report of etanercept for pediatric SJS/TEN.
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ParadisiAAbeniDBergamoFRicciFDidonaDDidonaB.Etanercept therapy for toxic epidermal necrolysis. J Am Acad Dermatol. 2014;71(2):278-283.
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Valeyrie-AllanorePWolkensteinLBrochardNet al. Open trial of ciclosporin treatment for Stevens-Johnson syndrome and toxic epidermal necrolysis. Br J Dermatol. 2010;163:847-853.
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Bellodi-SchmidtFShahKN.Beyond psoriasis: novel uses for biologic response modifiers in pediatric dermatology. Pediatr Dermatol. 2016;33(1):18-27.
