Steroid-induced osteonecrosis is unpredictable and highly morbid.
Methods:
MEDLINE (Ovid) and PubMed search for relevant literature.
Results:
Oral steroid doses typically considered to be associated with the condition are >20 mg of prednisone (or equivalent) per day or >2 g within a period of 2 to 3 months. Symptoms may be vague.
Conclusions:
Dermatologists must exercise a high degree of clinical suspicion and warn patients about steroid-related risks and conditions for follow-up.
MontMAJonesLCHungerfordDS. Nontraumatic osteonecrosis of the femoral head: ten years later. J Bone Joint Surg Am. 2006;88(5):1117-1132.
2.
NashJJNashAGLeachMEPoetkerDM. Medical malpractice and corticosteroid use. Otolaryngol Head Neck Surg. 2011;144(1):10-15.
3.
WolvertonSE. Can short courses of systemic corticosteroids truly cause osteonecrosis?Dermatol Ther. 2009;22(5):458-464.
4.
PowellCChangCNaguwaSMCheemaGGershwinME. Steroid induced osteonecrosis: an analysis of steroid dosing risk. Autoimmun Rev. 2010;9(11):721-743.
5.
LesterRSKnowlesSRShearNH. The risks of systemic corticosteroid use. Dermatol Clin. 1998;16(2):277-288.
6.
GebhardKLMaibachHI. Relationship between systemic corticosteroids and osteonecrosis. Am J Clin Dermatol. 2001;2(6):377-388.
7.
AaronRKVoisinetARacineJAliYFellerER. Corticosteroid-associated avascular necrosis: dose relationships and early diagnosis. Ann N Y Acad Sci. 2011;1240:38-46.
8.
FelsonDTAndersonJJ. Across-study evaluation of association between steroid dose and bolus steroids and avascular necrosis of bone. Lancet. 1987;1(8538):902-906.
9.
TangSCChanKCChowSP. Osteonecrosis of femoral head after topical steroid therapy. J R Coll Surg Edinb. 1986;31(5):321-323.
10.
LarocheMArletJMazieresB. Osteonecrosis of the femoral and humeral heads after intraarticular corticosteroid injections. J Rheumatol. 1990;17(4):549-551.
YamamotoTSchneiderRIwamotoYBulloughPG. Rapid destruction of the femoral head after a single intraarticular injection of corticosteroid into the hip joint. J Rheumatol. 2006;33(8):1701-1704.
13.
Assouline-DayanYChangCGreenspanAShoenfeldYGershwinME. Pathogenesis and natural history of osteonecrosis. Semin Arthritis Rheum. 2002;32(2):94-124.
14.
SeamonJKellerTSalehJCuiQ. The pathogenesis of nontraumatic osteonecrosis. Arthritis. 2012;2012:601-763.
15.
AnjanP KaushikAnusuyaDasQuanjunCui. Osteonecrosis of the femoral head: an update in year 2012. World J Orthop. 2012;3(5):49-57.
16.
DrescherWSchlieperGFloegeJEitnerF. Steroid-related osteonecrosis: an update. Nephrol Dial Transplant. 2011;26(9):2728-2731.
