This article discusses transformations underway within Indigenous health in northern British Columbia and Canada. We highlight two organizations that are working to create ethical space and cultural safety at the intersections of Indigenous knowledge about health and wellness, Western medicine, and healthcare services for Indigenous peoples in Canada. The article argues that the cultural, organizational, and systemic transformations necessary to address the deep and ongoing health inequities experienced by Indigenous populations should be rooted in Indigenous knowledges and should prioritize Indigenous voices, values, and concepts. Cultural safety, ethical space, and Two-Eyed Seeing are three examples of ideas anchored in Indigenous knowledges that speak to relationships at the interface of different systems of knowledge. We offer some examples of how a public health knowledge translation centre and a regional health service delivering organization are actualizing these concepts in their work nationally and regionally in northern British Columbia, Canada.
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