We conducted a systematic review about antibiotic-loaded bone cement (ALBC) with a focus on clinical evidence about ALBC in general, concerns about ALBC and ALBC cost.
BuchholzHWEngelbrechtH.Depot effects of various antibiotics mixed with Palacos resins. Chirurg1970; 41: 511–515.
2.
BuchholzHWElsonRAEngelbrechtE, et al. Management of deep infection of total hip replacement. J Bone Joint Surg Br1981; 63–B: 342–353.
3.
GristinaAGHobgoodCDWebbLX, et al. Adhesive colonization of biomaterials and antibiotic resistance. Biomaterials1987; 8: 423–426.
4.
HicksonCJMetcalfeDElgohariS, et al. Prophylactic antibiotics in elective hip and knee arthroplasty: an analysis of organisms reported to cause infections and national survey of clinical practice. Bone Joint Res2015; 4: 181–189.
5.
SchwarzEMParviziJGehrkeT, et al. International consensus meeting on musculoskeletal infection: research priorities from the general assembly questions. J Orthop Res2019; 37: 997–1006.
6.
FillinghamYSeth GreenwaldASGreinerJ, et al. Hip and knee section, prevention, local antimicrobials: proceedings of international consensus on orthopedic infections. J Arthroplasty2019; 34: S289–S292.
7.
ParviziJSalehKJRaglandPS, et al. Efficacy of antibiotic-impregnated cement in total hip replacement. Acta Orthop2008; 79: 335–341.
8.
WangJZhuCChengT, et al. A systematic review and meta-analysis of antibiotic-impregnated bone cement use in primary total hip or knee arthroplasty. PLoS One2013; 8: e82745.
9.
PedersenABSorensenHTMehnertF, et al. Risk factors for venous thromboembolism in patients undergoing total hip replacement and receiving routine thromboprophylaxis. J Bone Joint Surg Am2010; 92: 2156–2164.
10.
DaleHFenstadAMHallanG, et al. Increasing risk of prosthetic joint infection after total hip arthroplasty. Acta Orthop2012; 83: 449–458.
11.
ColasSCollinCPiriouP, et al. Association between total hip replacement characteristics and 3-year prosthetic survivorship: a population-based study. JAMA Surg2015; 150: 979–988.
12.
JamesonSSAsaadADiamentM, et al. Antibiotic-loaded bone cement is associated with a lower risk of revision following primary cemented total knee arthroplasty: an analysis of 731,214 cases using national joint registry data. Bone Joint J2019; 101–B: 1331–1347.
13.
SprowsonAPJensenCChambersS, et al. The use of high-dose dual-impregnated antibiotic-laden cement with hemiarthroplasty for the treatment of a fracture of the hip: the fractured hip infection trial. Bone Joint J2016; 98–B: 1534–1541.
14.
NambaRSInacioMCPaxtonEW.Risk factors associated with deep surgical site infections after primary total knee arthroplasty: an analysis of 56,216 knees. J Bone Joint Surg Am2013; 95: 775–782.
15.
QadirRSidhuSOchsnerJL, et al. Risk stratified usage of antibiotic-loaded bone cement for primary total knee arthroplasty: short term infection outcomes with a standardized cement protocol. J Arthroplasty2014; 29: 1622–1624.
16.
BiniSAChanPHInacioMC, et al. Antibiotic cement was associated with half the risk of re-revision in 1,154 aseptic revision total knee arthroplasties. Acta Orthop2016; 87: 55–59.
17.
NambaRSChenYPaxtonEW, et al. Outcomes of routine use of antibiotic-loaded cement in primary total knee arthroplasty. J Arthroplasty2009; 24(Suppl. 6): 44–47.
18.
GandhiRRazakFPathyR, et al. Antibiotic bone cement and the incidence of deep infection after total knee arthroplasty. J Arthroplasty2009; 24: 1015–1018.
19.
BohmEZhuNde GuiaN, et al. Does adding antibiotics to cement reduce the need for early revision in total knee arthroplasty?Clin Orthop Relat Res2014; 472: 162–168.
20.
BerberichCSanz-RuizP.Risk assessment of antibiotic resistance development by antibiotic-loaded bone cements: is it a clinical concern?EFORT Open Rev2019; 4: 576–584.
21.
HolleymanRJDeehanDJWalkerL, et al. Staphylococcal resistance profiles in deep infection following primary hip and knee arthroplasty: a study using the NJR dataset. Arch Orthop Trauma Surg2019; 139: 1209–1215.
22.
Wouthuyzen-BakkerMKheirMMMoyaI, et al. Failure after 2-stage exchange arthroplasty for treatment of periprosthetic joint infection: the role of antibiotics in the cement spacer. Clin Infect Dis2019; 68: 2087–2093.
23.
TyasBMarshMOswaldT, et al. Antibiotic resistance profiles of deep surgical site infections in hip hemiarthroplasty; comparing low dose single antibiotic versus high dose dual antibiotic impregnated cement. J Bone Jt Infect2018; 3: 123–129.
24.
WahligHDingeldeinE.Antibiotics and bone cements. Experimental and clinical long-term observations. Acta Orthop Scand1980; 51: 49–56.
25.
SpringerBDLeeGCOsmonD, et al. Systemic safety of high-dose antibiotic-loaded cement spacers after resection of an infected total knee arthroplasty. Clin Orthop Relat Res2004; 427: 47–51.
26.
Van RaaijTMVisserLEVultoAG, et al. Acute renal failure after local gentamicin treatment in an infected total knee arthroplasty. J Arthroplasty2002; 17: 948–950.
27.
PatrickBNRiveyMPAllingtonDR.Acute renal failure associated with vancomycin- and tobramycin-laden cement in total hip arthroplasty. Ann Pharmacother2006; 40: 2037–2042.
28.
CurtisJMSternhagenVBattsD.Acute renal failure after placement of tobramycin-impregnated bone cement in an infected total knee arthroplasty. Pharmacotherapy2005; 25: 876–880.
29.
CabritaHBCrociATCamargoOP, et al. Prospective study of the treatment of infected hip arthroplasties with or without the use of an antibiotic-loaded cement spacer. Clinics (Sao Paulo)2007; 62: 99–108.
30.
DovasSLiakopoulosVPapatheodorouL, et al. Acute renal failure after antibiotic-impregnated bone cement treatment of an infected total knee arthroplasty. Clin Nephrol2008; 69: 207–212.
31.
DaigleMEWeinsteinAMKatzJN, et al. The cost-effectiveness of total joint arthroplasty: a systematic review of published literature. Best Pract Res Clin Rheumatol2012; 26: 649–658.
32.
PiscitelliPIolasconGDi TannaG, et al. Socioeconomic burden of total joint arthroplasty for symptomatic hip and knee osteoarthritis in the Italian population: a 5-year analysis based on hospitalization records. Arthritis Care Res (Hoboken)2012; 64: 1320–1327.
33.
GandhiRBacksteinDZywielMG.Antibiotic-laden bone cement in primary and revision hip and knee arthroplasty. J Am Acad Orthop Surg2018; 26: 727–734.
34.
KleppelDStirtonJLiuJ, et al. Antibiotic bone cement’s effect on infection rates in primary and revision total knee arthroplasties. World J Orthop2017; 8: 946–955.
35.
CumminsJSTomekIMKantorSR, et al. Cost-effectiveness of antibiotic-impregnated bone cement used in primary total hip arthroplasty. J Bone Joint Surg Am2009; 91: 634–641.
36.
YayacMFRondonAJTanTL, et al. The economics of antibiotic cement in total knee arthroplasty: added cost with no reduction in infection rates. J Arthroplasty2019; 34: 2096–2101.