The case of an 83 year-old woman is presented in whom bilateral vitelliform macular cysts were observed to fluoresce during the pre-injection phase of intravenous fluorescein angiography. This suggests that the vitelliform response is a non-specific event occurring in retinal pigment epithelial disease in which lipofuscin may or may not be manufactured.
WolmanM.Pigments in pathology.New York and London: Academic Press1969; 223.
3.
NarayanK.A., KummerowF.A.Factors influencing the formation of complexes between oxidised lipids and proteins. J Am Oil Chemists’ Soc1963; 40: 339–42.
4.
WolmanM.Lipid carbonyls and products of oxidation of lipids. Ann Histochem1961; 6: 329–45.
5.
AndersonR.E., SperlingL.Lipids of ocular tissues. VII. Arch Biochem Biophys1971; 144: 673–7.
6.
WeiterJ.J., ZuckermanR.The influence of the photoreceptor - RPE complex on the inner retina. Ophthalmology1980; 87: 1133–9.
7.
YoungR.W.Solar radiation and age-related macular degeneration. Surv Ophthalmol1988; 32: 252–69.
8.
YoungR.W.Pathophysiology of age-related macular degeneration. Surv Ophthalmol1987; 31: 291–306.
9.
BidlackW.R., TappelA.L.Fluorescent products of phospholipids during lipid peroxidation. Lipids1973; 8: 203–7.
10.
ChioK.S., TappelA.L.Synthesis and characterization of the fluorescent products derived from malonaldehyde and amino acids. Biochemistry1969; 8: 2821–7.
11.
WolmanM.Pigments in pathology.New York and London: Academic Press1969; 193.
FontR.L., ZimmermanL.E., ArmalyM.F.The nature of the orange pigment over a choroidal melanoma: histochemical and electron microscopical observations. Arch Ophthalmol1974; 91: 359–62.
18.
MillerS.A.Fluorescence in Best's vitelliform dystrophy, lipofuscin and fundus flavimaculatus. Br J Ophthalmol1978; 62: 256–60.
