The clinical and pathological characteristics of a myoblastoma of the orbital are described. The tumor presented as a painless hard mass in the left orbit of a 56-year-old caucasian male, causing diplopia and hypertrophy of the left eye in the primary visual position. Light microscopy studies revealed a typical granular cell tumor with PAS-positive intracytoplasmic granules. Immunoperoxidase studies showed positivity for S-100 protein and desmin. Electron microscopy studies showed numerous intracellular myelin degenerative bodies. The patient developed an epidermoid cyst at the site of initial surgery, but has no signs of local or distant disease two years after initial treatment.
MiettinenM., LehtonenE., LehtolaH., EkblomP., Letho VirtanenI.Histogenesis of granular cell tumor - an immunohistochemical and ultrastructural study.J Pathol1984; 142: 221–9.
3.
LinaresJ., AlonsoJ., Varela-DuranJ., UrdíalesM., Diaz-FloresL.Estructura y origen del mioblastoma de células granulosas.Morfología Normal y Patológica1977; 1: 1–12.
4.
RodeJ., DhillonA.P., PapadakiL.Immonuhistochemical staining of granular cell tumor for neurone-specific enolase: evidence in support of a neural origin.Diagn Histopathol1982; 5: 205–11.
5.
StoutA.P., LattesR.Tumors of the soft tissues.Armed Forces Institute of Pathology1967; 92–3.
6.
TimmG., TimmelH.Zum Myoblastenmyom am Auge.Klin Monatsbl Augenheilkd1966; 148: 665–71.
7.
LackE.E., WorshamG.F., CallihanM.D.Granular cell tumor: a clinicopathogic study of 100 patients.J Surg Onc1980; 13: 301–6.
8.
ArminA., ConnellyE., RawdenG.An immunoperoxidase investigation of S-100 protein in granular cell myoblastomas: evidence for Schwann cell derivation.Am J Clin Pathol1983; 79: 37–44.
9.
AzzopardiJ.G.Histogenesis of granular cell myoblastoma.J Pathol Bacteriol1956; 71: 85–94.
10.
KubaczG.J.Malignant granular cell myoblastoma: report of a case.Aust NZJ Surg1971; 40: 291–5.
11.
MorganL.R., FryerM.P.Granular cell myoblastoma of the eye: case report.Plast Reconstr Surg1969; 43: 315–7.
12.
DunningtonJ.H.Granular cell myoblastoma of the orbit.Arch Ophthalmol1948; 40: 14–22.
13.
KarciogluZ.A.Granular cell tumor of the orbit. Case report and review of the literature.Ophthalmic Surg1983; 14: 125–9.
ConstanziG., BosincuL., DentiS., PittalugaS., SannaE.Evidence for collagen fibrils inside the cells of granular cell myoblastomas.Pathol Res Pract1980; 170: 61–9.
17.
DolmanP.J., RootmanJ., DolmanC.Infiltrating orbital granular cell tumor: a case report and literature review.Br J Ophthalmol1987; 71: 47–53.
18.
DrummondJ.W., HallD.L., SteenW.H., MaxeyS.A.Granular cell tumor (myoblastoma) of the orbit.Arch Ophthalmol1979; 97: 1492–4.
19.
FeyrterF.Uber eine eigenartige Geschwulstform des Nervegewebes im menschlichten Verdeungsschlauch.Virchows Arch (Pathol Anat)1935; 295: 480–501.
20.
FisherE.R., WechslerH.Granular cell muyoblastoma - a misnomer. Electron microscopic and histochemical evidence concerning its Schwann cell derivation and nature (granular cell Schwannoma).Cancer1962; 15: 936–54.
21.
Gonzales-AlmarezG., De BuenS., TsutsumiV.Granular cell tumor (myoblastoma) of the orbit.Am J Ophthalmol1975; 79: 606–12.
22.
MorganG.Granular cell myoblastoma of the orbit.Arch Ophthalmol1976; 94: 2135–42.
23.
MoriartyP., GarnerA., WrightJ.E.Case report of granular cell myoblastoma arising within the medial rectus muscle.Br J Ophthalmol1983; 67: 17–22.
24.
ObayashiK., YamadaY., KozakiM.Granular cell myoblastoma in the orbit.Folia Ophthalmol Jpn1969; 20: 566–74.
25.
SakamakyY.A case of intraorbital myoblastoma.Jpn J Clin Ophthalmol1963; 17: 883–4.
26.
SingletonE.M., NettleshipM.Granular cell tumor of the orbit: a case report.Ann Ophthalmol1983; 15: 881–3.
27.
HendersonD.W., PapadimitriouJ.M.Ultrastructural appearances of tumours. A diagnostic atlas.Edinburgh: Churchill Livingstone1982; 210–2.
28.
GoldsteinB.G., FontR.L., AlperM.G.Granular cell tumor of the orbit: a case report including electron microscopic observations.Ann Ophthalmol1982; 14: 231–8.
29.
StafanssonK., WollmannR.L.S-100 protein in granular cell tumors (granular cell myoblastomas).Cancer1982; 49: 1834–8.
30.
Ruiz-SauriA., Perez-BaceteM., Almenar-MedinasS., Llombart-BoschA.Soporte inmunohistoquímico para el origen schwaniano del llamado tumor de células granulosas. Estudio de seis casos.Patología1989; 22: 191–5.
31.
ShimoyamaI.A granular cell myoblastoma in the orbit.Neurol Med Chir (Tokyo)1984; 24: 355–8.
