Dentritic herpetic keratitis developed in a 49-year-old patient during topical acyclovir treatment. A positive herpes simplex culture was obtained. After acyclovir was replaced by trifluorthymidine and interferon, the dentritic lesion disappeared and herpes simplex culture became negative. Six months later a carcinoma of the larynx was diagnosed. The acyclovir-resistant herpetic keratitis may be associated with the carcinoma because resistant herpes simplex virus strains are predominantly described in patients suffering from immune deficiency.
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BirchC.J., TachedjianG., DohertyR.R., HayesK., GustI.D.Altered sensivity to antiviral drugs of herpes simplex virus isolates from a patient with the acquired immunodeficiency syndrome.J Infect Dis1990; 162: 731–4.
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