We report 4 eyes of 3 patients with presumed herpetic keratitis/keratouveitis after glaucoma surgery wherein intraoperative mitomycin-C was used.
Methods
Three patients, aged 18–75 years, were found to have unilateral or bilateral herpetic keratitis and/or keratouveitis, 15 days to 2 years after trabeculectomy with mitomycin-C.
Results
All 3 cases healed without any sequelae after 4 to 6 weeks with topical and/or systemic acyclovir. Topical steroids were used in cases with stromal involvement.
Conclusions
Mitomycin-C may predispose/facilitate development of herpetic keratitis/keratouveitis up to 2 years after glaucoma surgery.
KothariM.T., MehtaB.K., AsherN.S., KothariK.J.Recurrence of bilateral herpes simplex virus keratitis following bimatoprost use.Indian J Ophthalmol2006; 54: 47–8.
2.
EkatomatisP.Herpes simplex dendritic keratitis after treatment with latanoprost for primary open angle glaucoma.Br J Ophthalmol2001; 85: 1007–9.
3.
KaufmanH.E., VarnellE.D., ToshidaH., KanaiA., ThompsonH.W., BazanN.G.Effects of topical unoprostone and latanoprost on acute and recurrent herpetic keratitis in the rabbit.Am J Ophthalmol2001; 131: 643–6.
4.
OpenshawH., McNeillJ.I., LinX.H., NilandJ., CantinE.M.Herpes simplex virus DNA in normal corneas: persistence without viral shedding from ganglia.J Med Virol1995; 46: 75–80.
5.
CrouseC.A., PflugfelderS.C., PereiraI., ClearyT., RabinowitzS., AthertonS.S.Detection of herpes viral genomes in normal and diseased corneal epithelium.Curr Eye Res1990; 9: 569–81.
