Evaluation of static and dynamic pupillometry parameters in patients with central serous chorioretinopathy

Abstract

Background

Central serous chorioretinopathy (CSCR) is an idiopathic disease characterized by changes in the macular region between the neurosensory retina, the choroid and retinal pigment epithelium (RPE).

Objective

Compare pupillometry responses in CSCR patients with those of healthy individuals using automated pupillometry.

Methods

A total of 52 subjects were included in the study (26 acute CSCR and 26 control). All subjects underwent a complete ophthalmologic examination, including optical coherence tomography (OCT) and enhanced depth imaging spectral-domain optical coherence tomography (EDI-OCT). Both static and dynamic pupillometry measurements were performed under scotopic (0.1 cd/m²), mesopic (1 cd/m²), low-photopic (10 cd/m²), and high-photopic (100 cd/m²) light conditions. Dynamic pupillometry (resting PD, contraction amplitude, latency, duration, contraction velocity, dilation latency, and resting duration and velocity) measurements were performed using a white light stimulus in the dark.

Results

On static pupillometry, low-photopic and scotopic pupil diameters were larger in the acute CSCR group (p = 0.003 and p = 0.048, respectively), with no between-group differences under mesopic or high-photopic conditions. In the acute CSCR group, dynamic pupillometry parameters of contraction amplitude, dilation duration, and dilation latency significantly decreased (p = 0.024, p = 0.011 and p = 0.036, respectively), while initial pupil diameter and contraction latency increased (p = 0.026 and p = 0.047, respectively).

Conclusions

The results of this study support the idea that autonomic nervous system dysfunction plays a contributing role in the pathophysiology of the disease and suggest that pupillometry can be used as a non-invasive screening tool for autonomic dysfunction.