Analysis on the clinical correlation of lens parameters and choroidal thickness with the severity of primary angle closure disease

Abstract

Purpose: The purpose of this study is to investigate the correlation of lens parameters and choroidal thickness (RCS) with the severity of PACD and to compare those parameters with the normal population. Methods: Prospective, cross-sectional hospital-based study. A total of 286 subjects (572 eyes) including 236 study patients (472 eyes) and 50 age-matched controls (100 eyes) were included in the study. The parameters studied were anterior chamber depth (ACD), lens thickness (LT), anterior vault (AV), lens axial factor (LAF), lens position (LP), relative lens position (RLP), lens vault (LV) and RCS thickness. Results: The mean ACD was significantly shallow in all subtypes of Primary Angle Closure Glaucoma (PACG) (mean ± SD = 2.53 ± 0.34 mm) compared to controls (4.05 ± 0.16; p = 0.0001). Likewise, the mean lens thickness was more in all subtypes of PACD (mean ± SD = 4.67 ± 0.26 mm) than in normal controls (4.17 ± 0.17 mm; p = 0.0001). Moreover, PACD patients had higher LV (mean ± SD = 1174.29 ± 247.87) than in controls (778.23 ± 37.95; p = 0.0001), particularly in eyes with AAC (1328.86 ± 77.13). Other biometric parameters like AV, LAF, LP, RLP and RCS thickness revealed a statistically significant difference in PACD compared to the control population (p < 0.00001). Pairwise comparison also revealed significant difference in all ocular biometric parameters in AAC compared to other subtypes. Conclusion: Lens parameters and choroidal thickness correlated significantly with the severity of PACD. Our study highlights the interplay of multiple ocular biometric parameters with the disease severity, suggesting the individualised surgical options in patients with PACD.

Keywords

Primary angle closure disease acute angle closure lens parameters retinochoroidal thickness lens vault lens axial factor lens position

Get full access to this article

View all access options for this article.

References

Quigley

. Number of people with glaucoma worldwide. Br J Ophthalmol 1996; 80: 389–393.

Tham

Wong

, et al. Global prevalence of glaucoma and projections of glaucoma burden through 2040: a systematic review and meta-analysis. Ophthalmology 2014; 121: 2081–2090.

Foster

Johnson

. Glaucoma in China: how big is the problem? Br J Ophthalmol 2001; 85: 1277–1282.

Saxena

Agrawal

Pratap

, et al. Anterior chamber depth and lens thickness in primary angle-closure glaucoma: a case-control study. Indian J Ophthalmol 1993; 41: 71–73.

Sihota

Gupta

Agarwal

, et al. Comparison of symptomatic and asymptomatic, chronic, primary angle-closure glaucoma, open-angle glaucoma, and controls. J Glaucoma 2000; 9: 208–213.

Moghimi

Vahedian

Fakhraie

, et al. Ocular biometry in the subtypes of angle closure: an anterior segment optical coherence tomography study. Am J Ophthalmol 2013; 155: 664–673.e1.

Sood

Jain

Agarwal

. Ocular biometry in primary angle closure glaucoma in Indians. Indian J Med Res 1988; 88: 190–191.

Nongpiur

Amerasinghe

, et al. Lens vault, thickness, and position in Chinese subjects with angle closure. Ophthalmology 2011; 118: 474–479.

Kurysheva

Pomerantsev

Rodionova

, et al. Comparison of lens extraction versus laser iridotomy on anterior segment, choroid, and intraocular pressure in primary angle closure using machine learning. J Glaucoma 2023; 32: e43–e55.

10.

Azuara-Blanco

Burr

Ramsay

, et al. Effectiveness of early lens extraction for the treatment of primary angle-closure glaucoma (EAGLE): a randomised controlled trial. Lancet 2016; 388: 1389–1397.

11.

Foster

Buhrmann

Quigley

, et al. The definition and classification of glaucoma in prevalence surveys. Br J Ophthalmol 2002; 86: 238–242.

12.

Sihota

. Classification of primary angle closure disease. Curr Opin Ophthalmol 2011; 22: 87–95.

13.

George

Paul

Baskaran

, et al. Ocular biometry in occludable angles and angle closure glaucoma: a population based survey. Br J Ophthalmol 2003; 87: 399–402.

14.

Yang

Zhao

Liu

, et al. Nanophthalmos: an update on the biological parameters and fundus abnormalities. J Ophthalmol 2021; 2021: 8853811.

15.

Chen

Jiang

, et al.

What are the characteristics of primary angle closure with longer axial length?

Invest Ophthalmol Vis Sci 2018; 59: 1354–1359.

16.

Coh

Moghimi

Chen

, et al. Lens position parameters as predictors of intraocular pressure reduction after cataract surgery in glaucomatous versus nonglaucomatous eyes. Invest Ophthalmol Vis Sci 2016; 57: 2593–2599.

17.

Hsu

Kakigi

Lin

, et al. Lens position parameters as predictors of intraocular pressure reduction after cataract surgery in nonglaucomatous patients with open angles. Invest Ophthalmol Vis Sci 2015; 56: 7807–7813.

18.

Shin

Subrayan

Tajunisah

. Changes in anterior chamber depth and intraocular pressure after phacoemulsification in eyes with occludable angles. J Cataract Refract Surg 2010; 36: 1289–1295.

19.

Brown

Zhong

Whitman

, et al. Reduced intraocular pressure after cataract surgery in patients with narrow angles and chronic angle-closure glaucoma. J Cataract Refract Surg 2014; 40: 1610–1614.

20.

Thomas

Parikh

Muliyil

, et al. Five-year risk of progression of primary angle closure to primary angle closure glaucoma: a population-based study. Acta Ophthalmol Scand 2003; 81: 480–485.

Supplementary Material

Please find the following supplemental material available below.

For Open Access articles published under a Creative Commons License, all supplemental material carries the same license as the article it is associated with.

For non-Open Access articles published, all supplemental material carries a non-exclusive license, and permission requests for re-use of supplemental material or any part of supplemental material shall be sent directly to the copyright owner as specified in the copyright notice associated with the article.

0.00 MB

0.01 MB