Are optic nerve head and choroidal circulation affected by eye movements?

Abstract

Aim

Although it has been reported that the optic nerve can be mechanically affected by the eye's horizontal movements, studies examining horizontal movements with optical coherence tomography angiography (OCTA) have only recently begun to emerge. This study aimed to investigate whether there are changes in the OCTA data of healthy individuals in the primary gaze, abduction, and adduction.

Method

Thirty volunteers (15–73 years old) were included in this prospectively designed study. Radial peripapillary capillary density parameters (RPCD) taken with OCTA in cases of primary gaze, abduction, and adduction were examined. With the OCTA device Angio Disc QuickVue that was used in the study, 3 main vessel structures could be examined.

Result

In the patients’ primary, abduction, and adduction positions, a difference was observed only in the superior hemifield area of the left eye (P = 0.032). The superior hemifield all vessels vessel densities (AV VD) were 60.1 ± 2.7 in the central gaze, 59.9 ± 2.6 in the adduction, and 60.8 ± 2.6 in the abduction positions, with a relative decrease observed in adduction. This was also related to age. No difference was detected in terms of the other RPCD parameters.

Conclusion

In healthy individuals, short-term horizontal eye movements may not result in significant changes except for superior hemifield in OCTA data.

Keywords

Capillary density eye movement optical coherence tomography angiography

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References

Demer

. Optic nerve sheath as a novel mechanical load on the globe in ocular duction. Invest Ophthalmol Visual Sci 2016; 57: 1826–1838.

Lim

Tran

Garcia

, et al. Optical coherence tomography angiography demonstrates strain and volume effects on optic disk and peripapillary vasculature caused by horizontal duction. Curr Eye Res 2023; 48: 518–527.

Suh

Clark

Demer

. Optic nerve sheath tethering in adduction occurs in esotropia and hypertropia, but not in exotropia. Invest Ophthalmol Vis Sci 2018; 59: 2899–2904.

Demer

Clark

Suh

, et al. Magnetic resonance imaging of optic nerve traction during adduction in primary open-angle glaucoma with normal intraocular pressure. Invest Ophthalmol Vis Sci 2017; 58: 4114–4125.

Chang

Shin

Park

, et al. Deformation of optic nerve head and peripapillary tissues by horizontal duction. Am J Ophthalmol 2017; 174: 85–94.

Zhang

Huang

Zhang

, et al. Wide-field imaging of retinal vasculature using optical coherence tomography-based microangiography provided by motion tracking. J Biomed Opt 2015; 20: 066008.

Wang

Beotra

Tun

, et al. In vivo 3-dimensional strain mapping confirms large optic nerve head deformations following horizontal eye movements. Invest Ophthalmol Vis Sci 2016; 57: 5825–5833.

Kashani

Chen

Gahm

, et al. Optical coherence tomography angiography: a comprehensive review of current methods and clinical applications. Prog Retin Eye Res 2017; 60: 66–100.

Demer

. Optic nerve sheath as a novel mechanical load on the globe in ocular duction. Invest Ophthalmol Vis Sci 2016; 57: 1826–1838.

10.

Lee

. Intraocular vascular analysis using optical coherence tomography angiography in patients with vascular paralytic strabismus. PLoS One 2022; 17: e0272524.

11.

Chen

Lesgart

, et al. Age-dependent deformation of the optic nerve head and peripapillary retina by horizontal duction. Am J Ophthalmol 2020; 209: 107–116.

12.

Bazvand

Mirshahi

Fadakar

, et al. The quantitative measurements of vascular density and flow area of optic nerve head using optical coherence tomography angiography. J Glaucoma 2017; 26: 735–741.

13.

Tang

Cheng

Wang

, et al. Review: the development of risk factors and cytokines in retinal vein occlusion. Front Med (Lausanne) 2022; 9: 910600.

14.

Van Overbeeke

Sekhar

. Microanatomy of the blood supply to the optic nerve. Orbit 2003; 22: 81–88.

15.

Suh

Shin

, et al. Progressive deformation of the optic nerve head and peripapillary structures by graded horizontal duction. Invest Ophthalmol Vis Sci 2017; 58: 5015–5021.

16.

Zhao

Laotaweerungsawat

Chen

, et al. Right versus left eye asymmetry of microvasculature in diabetes revealed by optical coherence tomography angiography. Sci Rep 2023; 13: 9332.