A 64-year-old Caucasian woman was referred to our hospital after referring vision loss; she had been previously diagnosed with systemic diffuse large B-cell lymphoma. Retinal and optic nerve involvement were found in her right eye, and iris and vitreous involvement were found in her left eye. Vitreoretinal lymphomas (VRL) are rare in medical literature, hence there is a lack of standardised studies regarding therapeutic options in these patients. In our patient, we decided to add intravitreal injections of rituximab and methotrexate to systemic chemotherapy, and to perform pars plana vitrectomy.
MochizukiMSinghAD. Epidemiology and clinical features of intraocular lymphoma. Ocul Immunol Inflamm2009; 17(2): 69–72.
2.
SalomãoDRPulidoJSJohnstonPB, et al. Vitreoretinal presentation of secondary large B-cell lymphoma in patients with systemic lymphoma. JAMA Ophthalmol2013; 131(9): 1151–1158.
3.
TangLJGuCLZhangP. Intraocular lymphoma. Int J Ophthalmol2017; 10(8): 1301–1307.
4.
MetzCHSchuelerAMetzK, et al. Transretinal biopsy of intraocular lymphoma. Klin Monbl Augenheilkd2015; 232(7): 845–849.
5.
IttySPulidoJS. Rituximab for intraocular lymphoma. Retina2009; 29(2): 129–132.
6.
CicinelliMVMarcheseAMiserocchiE, et al. Retinal and choroidal changes of vitreoretinal lymphoma from active to remission phase after intravitreal rituximab. Ocul Immunol Inflamm2020; 28(4): 637–646.
7.
ZhouMXuG. Recent progress in the diagnosis and treatment of primary vitreoretinal lymphoma. Taiwan J Ophthalmol2016; 6(4): 170–176.
8.
EchegarayJJLlopSSepulvedaM, et al. Intravitreal rituximab for the treatment of a secondary intraocular relapse of a large B-cell lymphoma. Am J Ophthalmol Case Rep2018; 9: 77–79.
9.
VenkateshPGogiaVKhandujaS, et al. Therapeutic vitrectomy for vitreal recurrence of intraocular lymphoma resistant to intravitreal methotrexate post systemic chemotherapy. J Cancer Res Ther2015; 11(3): 668.
