Intravitreal Triamcinolone in the Treatment of Serous Pigment Epithelial Detachment and Occult Choroidal Neovascularization Secondary to Age-Related Macular Degeneration
Restricted accessAnnouncementFirst published online May, 2005
Intravitreal Triamcinolone in the Treatment of Serous Pigment Epithelial Detachment and Occult Choroidal Neovascularization Secondary to Age-Related Macular Degeneration
To report two cases of occult choroidal neovascularization (CNV) and serous pigment epithelial detachment (PED) treated with intravitreal triamcinolone (IVT) injections.
Methods
Interventional case reports.
Results
Both patients showed an increase in visual acuity and a complete flattening of the PED at 10 months (Case 1) and 4 months (Case 2) after IVT injections. No complications or adverse effects are reported.
Conclusions
Future studies should be designed to investigate if IVT can effectively influence the clinical and functional outcome of eyes with serous PED and occult CNV secondary to age-related macular degeneration, for which at the moment no treatment has been shown to be effective.
Verteporfin therapy for subfoveal choroidal neovascularization in age-related macular degeneration: three-year results of an open-label extension 2 randomized clinical trials— TAP report no. 5. Arch Ophthalmol2002; 120: 1307–14.
3.
JonasJ.B., AkkoyunI., BuddeW.M., KreissigI., DegenringR.F.Intravitreal reinjection of triamcinolone for exudative age-related macular degeneration. Arch Ophthalmol2004; 122: 218–22.
4.
Axer-SiegelR., EhrlichR., RosenblattI.Photodynamic therapy for occult choroidal neovascularization with pigment epithelium detachment in age-related macular degeneration. Arch Ophthalmol2004; 122: 453–9.
5.
GilliesM.C., SimpsonJ.M., LuoW.A randomized clinical trial of a single dose of intravitreal triamcinolone acetonide for neovascular age-related macular degeneration. Arch Ophthalmol2003; 121: 667–73.
6.
SpaideR.F., SorensonJ., MarananL.Combined photodynamic therapy with verteporfin and intravitreal triamcinolone acetonide for choroidal neovascularization. Ophthalmology2003; 110: 1517–25.
7.
KleinM.L., ObertynskiH., PatzA., FineS.L., KiniM.Follow-up study of detachment of the retinal pigment epithelium. Br J Ophthalmol1980; 64: 412–6.
8.
PenfoldP.L., WenL., MadiganM.C.Modulation of permeability and adhesion molecule expression by human choroidal endothelial cells. Invest Ophthalmol Vis Sci2002; 43: 3125–30.
9.
PerrettiM., AhluwaliaA.The microcirculation and inflammation: site of action for glucocorticoids. Microcirculation2000; 7: 147–61.
10.
ScholesG.N., O'BrienW.J., AbramsG.W., KubicekM.F.Clearance of triamcinolone from vitreous. Arch Ophthalmol1985; 103: 1567–9.
