In Vitro Analysis of AcrySof Intraocular Lens Glistening

Abstract

Purpose

The authors studied the effects of changes in packaging solution temperature on the development of glistening in acrylic intraocular lenses (AcrySof, Alcon).

Methods

Glistening was examined by slit lamp at each condition. In Experiment 1, Aciy S o f lenses were soaked in physiologic saline adjusted to 15°C and 37°C in an incubator. In Experiment 2, AcrySof lenses were soaked in physiologic saline adjusted to 37°C and 60°C for 5 min, then stored in physiologic saline adjusted to 15°C. In Experiment 3, glistening formation was induced in AcrySof lenses by soaking them in warm water (37°C). The lenses were allowed to dry at 15°C and then soaked in physiologic saline adjusted to 15°C. After storage of dry AcrySof lenses at 37°C in an incubator for 10 months followed by soaking in physiologic saline adjusted to 15°C, glistening formation was evaluated in Experiment 4.

Results

Glistening became observable after 1 month, despite the temperature having been lowered to 15°C. No glistening was observed in the lenses soaked in physiologic saline adjusted to 37°C after 5 min, but glistening was observed 1 month after soaking. When allowed to dry at 15°C, the glistening decreased. After 1 month of soaking at 15°C, glistening was again observable.

Conclusions

AcrySof lenses soaked in warm water for a short time may change characteristics, and therefore, close monitoring of the temperature and time of soaking is necessary to prevent glistening formation.