Melatonin is vital in human circadian rhythm and infant development. This scoping review summarized the current knowledge about melatonin’s presence and effects in human milk to promote better understanding of its secretion pattern and clinical advancement of maternal-infant health. The review followed the Joanna Briggs Institute guideline and answered the question: What is the current knowledge about melatonin hormone in human milk? The databases searched were PubMed, CINAHL, SCOPUS, Web of Science, LILACS, Scielo, EMBASE, Science Direct, Eric, Cochrane, in addition to grey literature and reference lists of included sources. Research papers included English, Spanish, or Portuguese languages, regardless of study type or publication date. The study selection and data extraction involved two independent reviewers. Twenty-nine studies met inclusion criteria. The studies, conducted between 1993 and 2023, employed diverse designs, with cross-sectional studies being the most prevalent. Melatonin concentration exhibited a consistent pattern, being higher at night, and elevated in colostrum. The analysis methods for melatonin concentration evolved, with recent advancements contributing to more accurate measurements. Factors influencing melatonin levels, such as delivery type, maternal age, and health conditions, demonstrated a complex relationship, potentially impacting the health and development of infants. The dynamic nature of melatonin in human milk calls for continued interdisciplinary research, bridging gaps between clinical, biochemical, and epidemiological perspectives. Standardizing melatonin analysis methods are needed. Nurses should assess factors influencing melatonin levels in milk to promote interventions and guidance aimed at enhancing the regulation of the circadian cycle during the perinatal period and its benefits.
AmaralF. G. D.Cipolla-NetoJ. (2018). A brief review about melatonin, a pineal hormone. Archives of Endocrinology and Metabolism, 62(4), 472–479. https://doi.org/10.20945/2359-3997000000066
Aparici-GonzaloS.Carrasco-GarcíaÁ.GombertM.Carrasco-LunaJ.Pin-ArboledasG.Codoñer-FranchP. (2020). Melatonin content of human milk: The effect of mode of delivery. Breastfeeding Medicine: The Official Journal of the Academy of Breastfeeding Medicine, 15(9), 589–594. https://doi.org/10.1089/bfm.2020.0157
4.
BallardO.MorrowA. L. (2013). Human milk composition: Nutrients and bioactive factors. Pediatric Clinics of North America, 60(1), 49–74. https://doi.org/10.1016/j.pcl.2012.10.002
Becker-AndréM.WiesenbergI.Schaeren-WiemersN.AndréE.MissbachM.SauratJ. H.CarlbergC. (1994). Pineal gland hormone melatonin binds and activates an orphan of the nuclear receptor superfamily. Journal of Biological Chemistry, 269(46), 28531–28534. https://doi.org/10.1074/jbc.272.26.16707
7.
BookerL. A.LenzK. E.SpongJ.Deacon-CrouchM.WilsonD. L.NguyenT. H.SkinnerT. C. (2023). High-temperature pasteurization used at donor breast milk banks reduces melatonin levels in breast milk. Breastfeeding Medicine: The Official Journal of the Academy of Breastfeeding Medicine, 18(7), 549–552. https://doi.org/10.1089/bfm.2023.0068
8.
Caba-FloresM. D.Ramos-LigonioA.Camacho-MoralesA.Martínez-ValenzuelaC.Viveros-ContrerasR.CabaM. (2022). Breast milk and the importance of chrononutrition. Frontiers in Nutrition, 9, 867507. https://doi.org/10.3389/fnut.2022.867507
9.
ÇalışkanC.ÇelikS.HatirnazS.ÇelikH.AvcıB.TinelliA. (2021). The role of delivery route on colostrum melatonin and serum Il-6 levels: A prospective controlled study. Zeitschrift für Geburtshilfe und Neonatologie, 225(6), 506–512. https://doi.org/10.1055/a-1524-3373
10.
ChitimusD. M.PopescuM. R.VoiculescuS. E.PanaitescuA. M.PavelB.ZagreanL.ZagreanA.-M. (2020). Melatonin’s impact on antioxidative and anti-inflammatory reprogramming in homeostasis and disease. Biomolecules, 10(9), 1211. https://doi.org/10.3390/biom10091211
11.
ChrustekA.Sinkiewicz-DarolE.LampkaM.Olszewska-SłoninaD.SperkowskaB.LinowieckaK. (2022). Effect of pasteurization on melatonin concentration in human breast milk. Postępy Higieny I Medycyny Doświadczalnej, 76(1), 220–227. https://doi.org/10.2478/ahem-2022-0022
12.
Cohen EnglerA.HadashA.ShehadehN.PillarG. (2012). Breastfeeding may improve nocturnal sleep and reduce infantile colic: Potential role of breast milk melatonin. European Journal of Pediatrics, 171(4), 729–732. https://doi.org/10.1007/s00431-011-1659-3
13.
Gila-DíazA.Herranz CarrilloG.CañasS.Saenz de PipaónM.Martínez-OrgadoJ. A.Rodríguez-RodríguezP.López de PabloÁ. L.Martin-CabrejasM. A.Ramiro-CortijoD.ArribasS. M. (2020). Influence of maternal age and gestational age on breast milk antioxidants during the first month of lactation. Nutrients, 12(9), 2569. https://doi.org/10.3390/nu12092569
14.
GombertM.Codoñer-FranchP. (2021). Melatonin in early nutrition: Long-term effects on cardiovascular system. International Journal of Molecular Sciences, 22(13), 6809. https://doi.org/10.3390/ijms22136809
15.
GroërM.DavisM.CaseyK.ShortB.SmithK.GroërS. (2005). Neuroendocrine and immune relationships in postpartum fatigue. MCN: The American Journal of Maternal/Child Nursing, 30(2), 133–138. https://doi.org/10.1097/00005721-200503000-00012
16.
Honorio-FrançaA. C.Pernet HaraC. C.OrmondeJ. V. S.Triches NunesG.Luzía FrançaE. (2013). Human colostrum melatonin exhibits a day-night variation and modulates the activity of colostral phagocytes. Journal of Applied Biomedicine, 11(3), 153–162. https://doi.org/10.2478/v10136-012-0039-2
17.
IllnerováH.BuresováM.PreslJ. (1993). Melatonin rhythm in human milk. Journal of Clinical Endocrinology and Metabolism, 77(3), 838–841. https://doi.org/10.1210/jcem.77.3.8370707
18.
ItalianerM. F.NaninckE. F. G.RoelantsJ. A.van der HorstG. T. J.ReissI. K. M.GoudoeverJ. B. vanJoostenK. F. M.ChavesI.VermeulenM. J. (2020). Circadian variation in human milk composition, a systematic review. Nutrients, 12(8), 2328. https://doi.org/10.3390/nu12082328
19.
JinW.GuiJ.LiG.JiangF.HanD. (2021). High-throughput quantitation of trace level melatonin in human milk by on-line enrichment liquid chromatography-tandem mass spectrometry. Analytica Chimica Acta, 1176, 338764. https://doi.org/10.1016/j.aca.2021.338764
20.
JnieneA.ErrguigL.El HangoucheA. J.RkainH.AboudrarS.El FtouhM.DakkaT. (2019). Perception of sleep disturbances due to bedtime use of blue light-emitting devices and its impact on habits and sleep quality among young medical students. BioMed Research International, 2019(1), 7012350. https://doi.org/10.1155/2019/7012350
21.
KatzerD.PauliL.MuellerA.ReutterH.ReinsbergJ.FimmersR.BartmannP.BagciS. (2016). Melatonin concentrations and antioxidative capacity of human breast milk according to gestational age and the time of day. Journal of Human Lactation: Official Journal of International Lactation Consultant Association, 32(4), NP105–NP110. https://doi.org/10.1177/0890334415625217
22.
KennawayD. J. (2019). A critical review of melatonin assays: Past and present. Journal of Pineal Research, 67(1), Article e12572. https://doi.org/10.1111/jpi.12572
LiH.BowenA.BowenR.BalbuenaL.FengC.BallyJ.MuhajarineN. (2020). Mood instability during pregnancy and postpartum: A systematic review. Archives of Women's Mental Health, 23(1), 29–41. https://doi.org/10.1007/s00737-019-00956-6
25.
Lungu-MoscaluA.NegutC. C.StefanovC.van StadenR.-I. S.BunaciuA. A.StadenJ. F. van. (2020). Rhodamine B - as new chromophore for the determination of melatonin in biological, food, and pharmaceutical samples. Combinatorial Chemistry & High Throughput Screening, 23(10), 1080–1089. https://doi.org/10.2174/1386207323666200628111958
26.
MarkusR. P.SousaK. S.da Silveira Cruz-MachadoS.FernandesP. A.FerreiraZ. S. (2021). Possible role of pineal and extra-pineal melatonin in surveillance, immunity, and first-line defense. International Journal of Molecular Sciences, 22(22), 12143. https://doi.org/10.3390/ijms222212143
McCarterD.LawA. A.CabulloH.PintoK. (2022). Scoping review of postpartum discharge education provided by nurses. Journal of Obstetric, Gynecologic, and Neonatal Nursing: JOGNN, 51(4), 377–387. https://doi.org/10.1016/j.jogn.2022.03.002
29.
MoladM.AshkenaziL.GoverA.Lavie-NevoK.Zaltsberg-BarakT.Shaked-MishanP.SoloveichikM.KesselI.RotschildA.EtzioniT. (2019). Melatonin stability in human milk. Breastfeeding Medicine: The Official Journal of the Academy of Breastfeeding Medicine, 14(9), 680–682. https://doi.org/10.1089/bfm.2019.0088
30.
MontaruliA.CastelliL.MulèA.ScuratiR.EspositoF.GalassoL.RovedaE. (2021). Biological rhythm and chronotype: New perspectives in health. Biomolecules, 11(4), 487. https://doi.org/10.3390/biom11040487
31.
MoonE.KimK.PartonenT.LinnarantaO. (2022). Role of melatonin in the management of sleep and circadian disorders in the context of psychiatric illness. Current Psychiatry Reports, 24(11), 623–634. https://doi.org/10.1007/s11920-022-01369-6
MoraisT. C.Honorio-FrançaA. C.FujimoriM.de QuentalO. B.PessoaR. S.FrançaE. L.de AbreuL. C. (2019). Melatonin action on the activity of phagocytes from the colostrum of obese women. Medicina, 55(10), 625. https://doi.org/10.3390/medicina55100625
34.
MorceliG.Honorio-FrançaA. C.FagundesD. L. G.CalderonI. M. P.FrançaE. L. (2013). Antioxidant effect of melatonin on the functional activity of colostral phagocytes in diabetic women. PLoS One, 8(2), Article e56915. https://doi.org/10.1371/journal.pone.0056915
35.
Namlı KalemM.KalemZ.YuceT.BakırararB.SöylemezF. (2018). Comparison of melatonin levels in the colostrum between vaginal delivery and cesarean delivery. American Journal of Perinatology, 35(5), 481–485. https://doi.org/10.1055/s-0037-1608681
36.
ParkerM. G.StellwagenL. M.NobleL.KimJ. H.PoindexterB. B.PuopoloK. M.SECTION ON BREASTFEEDING, COMMITTEE ON NUTRITION, COMMITTEE ON FETUS AND NEWBORN. (2021). Promoting human milk and breastfeeding for the very low birth weight infant. Pediatrics, 148(5), Article e2021054272. https://doi.org/10.1542/peds.2021-054272
37.
PereiraQ. L. C.HaraC. d. C. P.FernandesR. T. S.FagundesD. L. G.França-BotelhoA. d. C.GomesM. A.FrançaE. L.Honorio-FrançaA. C. (2018). Human colostrum action against Giardia lamblia infection influenced by hormones and advanced maternal age. Parasitology Research, 117(6), 1783–1791. https://doi.org/10.1007/s00436-018-5860-4
38.
PontesG. N.CardosoE. C.Carneiro‐SampaioM. M. S.MarkusR. P. (2006). Injury switches melatonin production source from endocrine (pineal) to paracrine (phagocytes) – melatonin in human colostrum and colostrum phagocytes. Journal of Pineal Research, 41(2), 136–141. https://doi.org/10.1111/j.1600-079X.2006.00345.x
39.
PontesG. N.CardosoE. C.Carneiro‐SampaioM. M. S.MarkusR. P. (2007). Pineal melatonin and the innate immune response: The TNF-alpha increase after cesarean section suppresses nocturnal melatonin production. Journal of Pineal Research, 43(4), 365–371. https://doi.org/10.1111/j.1600-079X.2007.00487.x
40.
PoundC.UngerS.BlairB. (2020). Pasteurized and unpasteurized donor human milk. Paediatrics and Child Health, 25(8), 549–550. https://doi.org/10.1093/pch/pxaa118
41.
QinY.ShiW.ZhuangJ.LiuY.TangL.BuJ.SunJ.BeiF. (2019). Variations in melatonin levels in preterm and term human breast milk during the first month after delivery. Scientific Reports, 9(1), 17984. https://doi.org/10.1038/s41598-019-54530-2
42.
SilvaK. M. R.FrançaD. C. H.de QueirozA. A.Fagundes-TrichesD. L. G.de MarchiP. G. F.MoraisT. C.Honorio-FrançaA. C.FrançaE. L. (2023). Polarization of melatonin-modulated colostrum macrophages in the presence of breast tumor cell lines. International Journal of Molecular Sciences, 24(15), 12400. https://doi.org/10.3390/ijms241512400
43.
SilvaN. A.Honorio-FrancaA. C.GiachiniF. R.MoresL.SouzaE. G. d.FrancaE. L. (2013). Bioactive factors of colostrum and human milk exhibits a day-night variation. American Journal of Immunology, 9(2), 68–74. https://doi.org/10.3844/ajisp.2013.68.74
44.
SriramanN. K. (2017). The nuts and bolts of breastfeeding: Anatomy and physiology of lactation. Current Problems in Pediatric and Adolescent Health Care, 47(12), 305–310. https://doi.org/10.1016/j.cppeds.2017.10.001
45.
Stefan-van StadenR.-I.Lungu-MoscaluA.van StadenJ. F. (2019). Pattern recognition of melatonin using stochastic sensors. New Journal of Chemistry, 43(13), 5196–5201. https://doi.org/10.1039/C9NJ00588A
46.
VerteramoR.PierdomenicoM.GrecoP.MilanoC. (2022). The role of melatonin in pregnancy and the health benefits for the newborn. Biomedicines, 10(12), 3252. https://doi.org/10.3390/biomedicines10123252
47.
VineT.BrownG. M.FreyB. N. (2022). Melatonin use during pregnancy and lactation: A scoping review of human studies. Revista Brasileira de Psiquiatria, 44(3), 342–348. https://doi.org/10.1590/1516-4446-2021-2156
YaoS.LiuX.FuY.GuanS.LiuY.YanL.HeP.LiuG. (2023). A rapid method to measure melatonin in biological fluids (milk and serum) with liquid chromatography-tandem mass spectrometry. Food Chemistry, 404(Pt A), 134606. https://doi.org/10.1016/j.foodchem.2022.134606
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