Purpose: The aims for this article are to provide an overview of the current state of research on genetic contributions to the development of childhood obesity and to suggest genetic-focused nursing practices to prevent childhood obesity. Organizing Constructs: Genetic epidemiology of childhood obesity, modes to identifying obesity genes, types of human obesity genes, and nursing implications are discussed. Clinical Relevance: The successful integration of genetics into nursing practice will provide opportunities for nurses to participate fully as major agents and collaborators in the health care revolution. Conclusions: Practicing nurses across the profession will need to become knowledgeable about genetics and take part in obesity prevention through genetic assessment of susceptibility and appropriate environmental interventions.
Barsh, G.S., Farooqi, I.S., O’Rahilly, S. ( 2000). Genetics of bodyweight regulation. Nature , 404, 644-651.
2.
Bell, C.G., Walley, A.J., Froguel, P. ( 2005). The genetics of human obesity. Nature Reviews, Genetics, 6, 221-234.
3.
Bogardus, C. ( 2009). Missing heritability and GWAS utility. Obesity, 17, 209-210.
4.
Centers for Disease Control and Prevention. ( 2006). National Health and Nutrition Examination Survey. Retrieved from http://www.cdc.gov/nchs/nhanes.htm
5.
Clement, K. ( 2005). Genetics of human obesity. Proceedings of the Nutrition Society, 64, 133-142.
6.
Clement, K., Ferre, P. ( 2003). Genetics and the pathophysiology of obesity. Pediatric Research, 53, 721-725.
7.
Consensus Panel on Genetic/Genomic Nursing Competencies. ( 2009). Essentials of genetic and genomic nursing: Competencies, curricula guidelines, and outcome indicators (2nd ed.). Silver Spring, MD: American Nurses Association. Retrieved from http://www.nursingworld.org/MainMenuCategories/EthicsStandards/Genetics_1.aspx
Dina, C., Meyre, D., Gallina, S., Durand, E., Korner, A., Jacobson, P., ... Froguel, P. ( 2007). Variation in FTO contributes to childhood obesity and severe adult obesity. Nature Genetics, 39, 724-726.
15.
Farooqi, I.S., O’Rahilly, S. ( 2005). Monogenic obesity in humans. Annual Review of Medicine, 56, 443-458.
16.
Frayling, T.M., Timpson, N.J., Weedon, M.N., Zeggini, E., Freathy, R.M., Lindgren, C.M., ... McCarthy, M.I. ( 2007). A common variant in the FTO gene is associated with body mass index and predisposes to childhood and adult obesity. Science, 316, 889-894.
17.
Fullerton, S.M., Clark, A.G., Weiss, K.M., Nickerson, D.A., Taylor, S.L., Stengård, J.H., ... Sing, C.F. ( 2000). Apolipoprotein E variation at the sequence haplotype level: Implications for the origin and maintenance of a major human polymorphism . American Journal of Human Genetics, 67, 881-900.
18.
Herbert, A., Gerry, N.P., McQueen, M.B., Heid, I.M., Pfeufer, A., Illig, T., ... Christman, M.F. ( 2006). A common genetic variant is associated with adult and childhood obesity. Science, 312, 279-283.
19.
Hinney, A., Hebebrand, J. ( 2008). Polygenic obesity in humans. Obesity Facts, 1, 35-42.
20.
Jackson, R.S., Creemers, J.W., Ohagi, S., Raffin-Sanson, M.L., Sanders, L., Montague, C.T., ... O’Rahilly, S. (1997). Obesity and impaired prohormone processing associated with mutations in the human prohormone convertase 1 gene. Nature Genetics, 16, 303-306.
21.
Jiang, Y., Tsai, T.F., Bressler, J. & Beaudet, A.L. ( 1998). Imprinting in Angelman and Prader-Willi syndromes. Current Opinion in Genetics & Development, 8, 334-342.
22.
Krebs, N.F., Jacobson, M.S., American Academy of Pediatrics, Committee on Nutrition. ( 2003). Prevention of pediatric overweight and obesity. Pediatrics, 112, 424-430.
23.
Krude, H., Biebermann, H., Luck, W., Horn, R., Brabant, G., Grüters, A. ( 1998). Severe early-onset obesity, adrenal insufficiency and red hair pigmentation caused by POMC mutations in humans. Nature Genetics, 19, 155-157.
24.
Lea, D.H. ( 2002). What nurses need to know about genetics. Dimensions of Critical Care Nursing, 21, 50-60.
25.
Lea, D.H. ( 2009). Basic genetics and genomics: A primer for nurses. Online Journal of Issues in Nursing, 14. doi: 10.3912/ OJIN.Vol14No02PPT01.
26.
Lee, Y.S. ( 2009). Consequences of childhood obesity. Annals of the Academy of Medicine, 38, 75-81.
27.
Liu, Y.J., Araujo, S.Recker, R.R., Deng, H.W. ( 2003). Molecular and genetic mechanisms of obesity: Implications for future management. Current Molecular Medicine, 3, 325-340.
28.
Lohmueller, K.E., Pearce, C.L., Pike, M., Lander, E.S., Hirschhorn, J.N. ( 2003). Metaanalysis of genetic association studies supports a contribution of common variants to susceptibility to common disease. Nature Genetics, 33, 177-182.
29.
Loos, R.J., Bouchard, C. ( 2008). FTO: The first gene contributing to common forms of human obesity. Obesity Reviews, 9, 246-290.
30.
Lyon, H.N., Hirschhorn, J.N. ( 2005). Genetics of common forms of obesity: A brief overview . American Journal of Clinical Nutrition, 82, 215S-217S.
31.
Maes, H.H., Neale, M.C., Eaves, L.J. ( 1997). Genetic and environmental factors in relative body weight and human adiposity. Behavior Genetics, 27, 325-351.
32.
Montague, C.T., Farooqi, S., Whitehead, J.P., Soos, M.A., Rau, H., Wareham, N.J., ... O’Rahilly, S. (1997). Congenital leptin deficiency is associated with severe early-onset obesity in humans. Nature, 387, 903-907.
33.
Mutch, D.M., Clément, K. ( 2006). Unraveling the genetics of human obesity. PLoS Genetics, 2, 1956-1963.
34.
National Center for Biotechnology Information. ( 2002). Single nucleotide polymorphism database (dbSNP) of nucleotide sequence variation. Retrieved July 15, 2009, from the NCBI Handbook at http://www.ncbi.nlm.nih.gov/bookshelf/br.fcgi?book=handbook&part=ch5
35.
National Institutes of Health, National Human Genome Research Institute. (n.d.). Talking glossary of genetic terms. Retrieved from genome.gov at http://www.genome.gov/glossary/?id=0
Rankinen, T., Zuberi, A., Chagnon, Y.C., Weisnagel, S.J., Argyropoulos, G., Walts, B., ... Bouchard, C. ( 2006). The human obesity gene map: The 2005 update. Obesity, 14, 529-644.
39.
Redon, R., Ishikawa, S.I., Fitch, K.R., Feuk, L., Perry, G.H., Andrews, T.D., ... Hurles, M.E. ( 2006). Global variation in copy number in the human genome. Nature, 444, 444-454.
40.
Rowen, L. ( 2009). Overview and summary: Obesity on the rise: What can nurses do?Online Journal of Issues in Nursing, 14. doi: 10.3912/OJIN.Vol14No1ManOS.
41.
Schwimmer, J.B., Burwinkle, T.M., Varni, J.W. ( 2003). Health-related quality of life of severely obese children and adolescents. The Journal of the American Medical Association , 289, 1813-1819.
42.
Scuteri, A., Sanna, S., Chen, W.M., Uda, M., Albai, G., Strait, J., ... Abecasis, G.R. ( 2007). Genome-wide association scan shows genetic variants in the FTO gene are associated with obesity-related traits. PLoS Genetics, 3, 1200-1210.
43.
Sorensen, T.I., Price, R.A., Stunkard, A.J., Schulsinger, F. ( 1989). Genetics of obesity in adult adoptees and their biological siblings. British Medical Journal, 298, 87-90.
44.
Speiser, P.W., Rudolf, M.C., Anhalt, H., Camacho-Hubner, C., Chiarelli, F., Eliakim, A., ... Hochberg, Z. ( 2005). Childhood obesity. Journal of Clinical Endocrinology & Metabolism, 90, 1871-1887.
45.
Stunkard, A.J., Foch, T.T., Hrubec, Z. ( 1986). A twin study of human obesity. The Journal of the American Medical Association, 256, 51-54.
46.
Stunkard, A.J., Harris, J.R., Pedersen, N.L., McClearn, G.E. ( 1990). The body-mass index of twins who have been reared apart . New England Journal of Medicine, 322, 1483-1487.
47.
Stunkard, A.J., Sorensen, T.I., Hanis, C., Teasdale, T.W., Chakraborty, R., Schull, W.J., & Schulsinger, F. (1986). An adoption study of human obesity. New England Journal of Medicine, 314, 193-198.
48.
Tönjes, A., Zeggini, E., Kovacs, P., Böttcher, Y., Schleinitz, D., Dietrich, K., ... Stumvoll, M. ( 2010). Association of FTO variants with BMI and fat mass in the self-contained population of Sorbs in Germany. European Journal of Human Genetics, 18, 104-110. doi: 10.1038/ejhg.2009.107.
49.
U.S. Department of Health and Human Services. (n.d.). Surgeon General’s family history initiative. Retrieved from http://www.hhs.gov/familyhistory/
50.
U.S. Department of Health and Human Services. ( 2006). Healthy people 2010. Retrieved from http://www.healthypeople.gov
51.
Vaisse, C., Clement, K., Guy, G.B., Froguel, P. ( 1998). A frameshift mutation in human MC4R is associated with a dominant form of obesity. Nature Genetics, 20, 113-114.
52.
Wattendorf, D.J., Hadley, D.W. ( 2005). Family history: The three-generation pedigree. American Family Physician, 72, 441-448.
53.
Yang, W., Kelly, T., He, J. ( 2007). Genetic epidemiology of obesity. Epidemiologic Reviews, 29, 49-61.
54.
Zeller, M.H., Modi, A.C. ( 2008). Psychosocial factors related to obesity in children and adolescents. In E. Jelalian & R. G Steele (Eds.), Handbook of childhood and adolescent obesity (pp. 25-42). New York, NY: Springer.
