Mucosal soft tissue lesions are fairly common in the pediatric population. However, the precise prevalence is unknown. This is the result of the limited number of studies, the use of various diagnostic criteria in those studies, and the transient nature of commonly encountered lesions in this population. In this section, we seek to familiarize the pediatric pathologist with a sampling of mucosal soft tissue lesions encountered in pediatric patients, highlight key diagnostic features and correlations with systemic diseases should they exist.
ShulmanJD. Prevalence of oral mucosal lesions in children and youths in the USA. Int J Paediatr Dent. 2005;15:89-97.
2.
MajoranaABardelliniEFlocchiniPAmadoriFContiGCampusG. Oral mucosal lesions in children from 0 to 12 years old: ten years’ experience. Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 2010;110:e13-e18.
SiamantasIKalogirouEMTosiosKI, et al. Spongiotic gingival hyperplasia synchronously involving multiple sites: case report and review of the literature. Head Neck Pathol. 2018;12:517-521.
5.
MentaMSNParkJHLourençoSV. Mucocele in pediatric patients: analysis of 36 children. Pediatr Dermatol. 2008;25:308-311.
6.
WuCWKaoYHChenCM, et al. Mucoceles of the oral cavity in pediatric patients. Kaohsiung J Med Sci. 2011;27:276-279.
7.
QualiaCMBrownMRRyanCKRossiTM. Oral mucosal neuromas leading to the diagnosis of multiple endocrine neoplasia type 2B in a child with intestinal pseudo-obstruction. Gastroenterol Hepatol. 2007;3:208-211.
8.
CangiarellaJJagirdarJAdelmanHBudzilovichGGrecoMA. Mucosal neuromas and plexiform neurofibromas: an immunocytochemical study. Pediatr Pathol. 1993;13:281-288.
9.
HenkeRPGuèrin-ReverchonIMilde-LangoschKKoppangHSLöningT. In situ detection of human papillomavirus types 13 and 32 in focal epithelial hyperplasia of the oral mucosa. J Oral Pathol Med. 1989;18:419-421.
10.
ArchardHOHeckJWStanleyHR. Focal epithelial hyperplasia: an unusual oral mucosal lesion found in Indian children. Oral Surg Oral Med Oral Pathol. 1965;20:201-212.
11.
CarlosRSedanoHO. Multi focal papillomavirus epithelial hyp-erplasia. Oral Surg Oral Med Oral Pathol. 1994;77:631-635.
PhiliponeEYoonAJ. Oral Pathology in the Pediatric Patients—A Clinical Guide to the Diagnosis and Treatment of Mucosal Lesions. Springer US; 2016.
17.
RuggELMcLeanWHAllisonWE, et al. A mutation in the mucosal keratin K4 is associated with oral white sponge nevus. Nat Genet. 1995;11:450-452.
18.
TerrinoniARuggELLaneEB, et al. A novel mutation in the keratin 13 gene causing oral white sponge nevus. J Dent Res. 2001;80:919-923.
19.
QuintellaCJansonGAzevedoLRDamanteJH. Orthodontic therapy in a patient with white sponge nevus. Am J Orthod Dentofac Orthop. 2004;125:497-499.
20.
ElfatoikiFZCapatasSSkaliHDHaliFAttarHChihebS, Oral White sponge nevus: an exceptional differential diagnosis in childhood. Case Rep Dermatol Med. 2020;2020:9296768.
21.
SanjeetaNNandiniDPremlataTBanerjeeS. White sponge nevus: report of three cases in a single family. J Oral and Maxillofacial Pathol. 2016;20:300-303.
22.
OtobeIde SousaSOMatthewsRWMigliariDA. White sponge naevus: improvement with tetracycline mouth rinse: report of four cases. Clin Exp Dermatol. 2007;32:749-751.
23.
ChaiRLOzolekJABranstetterBFMehtaDKSimonsJP. Congenital choristomas of the oral cavity in children. Laryngescope. 2011;121(10):2100-2106.
24.
ManorYBuchnerAPelegMTaicherS. Lingual cyst with respiratory epithelium: an entity of debatable histogenesis. J Oral Maxillofac Surg. 1999;57:124-127.
25.
BoueDRSmithGAKrousHF. Lingual bronchogenic cyst in a child: an unusual site of presentation. Fetal Pediatr Pathol. 1994;14:201-205.
26.
HorieNShimoyamaTKawanoR, et al. Lateral lingual cyst with respiratory epithelium: a rare case. Oral Surg. 2008;1:198-200.
27.
WillnerAFeghaliJBassilaM. An enteric duplication cyst occurring in the anterior two-thirds of the tongue. Int J Pediatr Otorhinolaryngol. 1991;21:169-177.
28.
LeeMYJensenEKwakSLarsonRA. Metastatic adenocarcinoma arising in a congenital foregut cyst of the esophagus. Am J Clin Oncol. 1998;21:64-66.
29.
VolchokJJafferACooperT, et al. Adenocarcinoma arising in a lingual foregut duplication cyst. Arch Otolaryngol Head Neck Surg. 2007;133:717-719.
30.
BoffanoPBenechRRocciaF, et al. Review of peripheral giant cell granulomas. J Craniofac Surg. 2013;24:2206-2208.
31.
GnepDR. Diagnostic Surgical Pathology of the Head and Neck. Saunders/Elsevier; 2009.
32.
LesterSRCordellKGRosebushMSPalaiologouAAManeyP. Peripheral giant cell granulomas: a series of 279 cases. Oral Surg Oral Med Oral Pathol Oral Radiol. 2014;118:475-482.
33.
LiuBYuSFLiTJ. Multinucleated giant cells in various forms of giant cell containing lesions of the jaws express features of osteoclasts. J Oral Pathol Med. 2003;32:367.
34.
CarvalhoYRLoyolaAMGomezRSAraujoVC. Peripheral giant cell granuloma. An immuno-histochemical and ultrastructural study. Oral Dis. 1995;1:20-25.
35.
MotamediMHEshghyarNJafariSM, et al. Peripheral and central giant cell granulomas of the jaws: a demographic study. Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 2007;103:e39-e43.
36.
PattnaikNRajguruJPPattanaikSJBardhanDNayakBIslamMMF. Coexistence of hyperparathyroidism and peripheral giant cell granuloma of the jaw: a rare case report. J Family Med Prim Care. 2020;9:3142-3146.
