Abstract
The Expert Panel for Cosmetic Ingredient Safety reviewed newly available studies since their original assessment in 2001, along with updated information regarding product types and concentrations of use, and confirmed that PPG-11 and PPG-15 Stearyl Ether are safe as cosmetic ingredients in the practices of use and concentration as described in this report.
The Expert Panel for Cosmetic Ingredient Safety first published a Final Report on the Safety Assessment of PPG-11 and PPG-15 Stearyl Ether in 2001. 1 The Expert Panel concluded that these ingredients are safe as used in cosmetics, as described in the safety assessment.
Current and Historical Frequency and Concentration of Use According to Duration and Exposure.
*Ingredient concentrations were not presented by specific product category in the original 2001 report; therefore, concentrations of these ingredients are only stated in the “totals” column. In addition, concentrations were provided for multiple years (1984 and 1998). The concentration range presented in the “total” column represents the concentration range for the ingredient reported by ICI Surfactants in 1998.
aIt is possible these products are sprays, but it is not specified whether the reported uses are sprays.
bIt is possible these products are powders, but it is not specified whether the reported uses are powders.
cNot specified whether a spray or a powder, but it is possible the use can be as a spray or a powder; therefore, the information is captured in both categories.
NR, no reported use.
An extensive search of the world’s literature was performed for published studies dated 1994 forward, and a study regarding the penetration enhancement potential of PPG-15 Stearyl Ether was found. 4 While the Expert Panel agreed that the published literature did not reveal toxicity or other data that warrant re-evaluation of the safety of these ingredients in cosmetic products, they did caution that care should be taken in formulating cosmetic products that may contain this ingredient in combination with any ingredient whose safety was based on their lack of dermal absorption data, or when dermal absorption was a concern.
After reviewing updated frequency and concentration of use data and toxicity and safety data, the Expert Panel determined to not reopen this safety assessment on PPG-11 and PPG-15 Stearyl Ether and reaffirmed the original conclusion.
Footnotes
Author’s Note
Unpublished sources cited in this report are available from the Director, Cosmetic Ingredient Review, 1620 L Street, NW, Suite 1200, Washington, DC 20036, USA.
Author Contributions
The articles in this supplement were sponsored by the Cosmetic Ingredient Review.
Declaration of Conflicting Interest
The author(s) declared the following potential conflicts of interest with respect to the research, authorship, and/or publication of this article: The articles in this supplement were sponsored by the Cosmetic Ingredient Review.
Funding
The author(s) disclosed receipt of the following financial support for the research, authorship, and/or publication of this article: The articles in this supplement were sponsored by the Cosmetic Ingredient Review. The Cosmetic Ingredient Review is financially supported by the Personal Care Products Council.