Notable clinical research published in 2023 related to cardiac anesthesia included studies focused on resuscitation and pharmacology, regional anesthesia, technological advances, and novel gene therapies. We reviewed 241 articles to identify 25 noteworthy studies that represent the most significant research related to cardiac anesthesia from the past year. Overall, improvements in clinical practice have enabled decreased morbidity and mortality with a renewed focus on mechanical circulatory support and transplantation.
ClendenenNAhlgrenBRobitailleMJ, et al.Year in review 2020: noteworthy literature in cardiothoracic anesthesiology. Semin CardioThorac Vasc Anesth. 2021;25(2):94-106. doi:10.1177/10892532211013614
2.
SmorodaADouinDMorabitoJ, et al.Year in review 2021: noteworthy literature in cardiothoracic anesthesia. Semin CardioThorac Vasc Anesth. 2022;26(2):107-119. doi:10.1177/10892532221100660
3.
ChasséMFergussonDATinmouthA, et al.Effect of donor sex on recipient mortality in transfusion. N Engl J Med. 2023;388(15):1386-1395. doi:10.1056/NEJMoa2211523
4.
CarsonJLBrooksMMHébertPC, et al.Restrictive or liberal transfusion strategy in myocardial infarction and anemia. N Engl J Med. 2023;389(26):2446-2456. doi:10.1056/NEJMoa2307983
5.
ConenDKe WangMPopovaE, et al.Effect of colchicine on perioperative atrial fibrillation and myocardial injury after non-cardiac surgery in patients undergoing major thoracic surgery (COP-AF): an international randomised trial. Lancet. 2023;402(10413):1627-1635. doi:10.1016/S0140-6736(23)01689-6
6.
GhadimiKCappielloJLWrightMC, et al.Inhaled epoprostenol compared with nitric oxide for right ventricular support after major cardiac surgery. Circulation. 2023;148(17):1316-1329. doi:10.1161/CIRCULATIONAHA.122.062464
7.
DharRMarklinGFKlinkenbergWD, et al.Intravenous levothyroxine for unstable brain-dead heart donors. N Engl J Med. 2023;389(22):2029-2038. doi:10.1056/NEJMoa2305969
8.
WoldendorpKManuelLSrivastavaADoaneMBassinLMarshmanD. Perioperative transfusion and long-term mortality after cardiac surgery: a meta-analysis. Gen Thorac Cardiovasc Surg. 2023;71(6):323-330. doi:10.1007/s11748-023-01923-w
9.
BlajchmanMA. Immunomodulation and blood transfusion. Am J Therapeut. 2002;9(5):389-395
10.
ChenLXiangFHuY. Corticosteroids in patients undergoing cardiac surgery: a meta-analysis of 12,559 patients. Perfusion. 2023;38(4):853-859. doi:10.1177/02676591221106324
11.
NairASaxenaPBorkarNRangaiahMAroraNMohantyPK. Erector spinae plane block for postoperative analgesia in cardiac surgeries- A systematic review and meta-analysis. Ann Card Anaesth. 2023;26(3):247-259. doi:10.4103/aca.aca_148_22
12.
ZhangSWuXGuoHMaL. Thoracic epidural anesthesia improves outcomes in patients undergoing cardiac surgery: meta-analysis of randomized controlled trials. Eur J Med Res. 2015;20(1):25. doi:10.1186/s40001-015-0091-y
13.
ChinKJAdhikarySDForeroM. Erector spinae plane (ESP) block: a new paradigm in regional anesthesia and analgesia. Curr Anesthesiol Rep. 2019;9(3):271-280. doi:10.1007/s40140-019-00333-0
14.
ThyregodHGHJørgensenTHIhlemannN, et al.Transcatheter or surgical aortic valve implantation: 10-year outcomes of the NOTION trial. Eur Heart J. 2024;45:1116-1124. doi:10.1093/eurheartj/ehae043. Published online February 7, 2024:ehae043
15.
van Beek-PeetersJJAMvan der MeerJBLFaesMC, et al.Professionals’ views on shared decision-making in severe aortic stenosis. Heart. 2022;108(7):558-564. doi:10.1136/heartjnl-2021-320194
16.
GillespieMJMcElhinneyDBJonesTK, et al.1-Year outcomes in a pooled cohort of harmony transcatheter pulmonary valve clinical trial participants. JACC Cardiovasc Interv. 2023;16(15):1917-1928. doi:10.1016/j.jcin.2023.03.002
17.
StoneGWAbrahamWTLindenfeldJ, et al.Five-year follow-up after transcatheter repair of secondary mitral regurgitation. N Engl J Med. 2023;388(22):2037-2048. doi:10.1056/NEJMoa2300213
18.
MakkarRRChikweJChakravartyT, et al.Transcatheter mitral valve repair for degenerative mitral regurgitation. JAMA. 2023;329(20):1778-1788. doi:10.1001/jama.2023.7089
MackMJLeonMBThouraniVH, et al.Transcatheter aortic-valve replacement in low-risk patients at five years. N Engl J Med. 2023;389(21):1949-1960. doi:10.1056/NEJMoa2307447
21.
SorajjaPWhisenantBHamidN, et al.Transcatheter repair for patients with tricuspid regurgitation. N Engl J Med. 2023;388(20):1833-1842. doi:10.1056/NEJMoa2300525
22.
ZeymerUFreundAHochadelM, et al.Venoarterial extracorporeal membrane oxygenation in patients with infarct-related cardiogenic shock: an individual patient data meta-analysis of randomised trials. Lancet. 2023;402(10410):1338-1346. doi:10.1016/S0140-6736(23)01607-0
23.
ThieleHZeymerUAkinI, et al.Extracorporeal life support in infarct-related cardiogenic shock. N Engl J Med. 2023;389(14):1286-1297. doi:10.1056/NEJMoa2307227
24.
SuvereinMMDelnoijTSRLorussoR, et al.Early extracorporeal CPR for refractory out-of-hospital cardiac arrest. N Engl J Med. 2023;388(4):299-309. doi:10.1056/NEJMoa2204511
25.
YannopoulosDBartosJRaveendranG, et al.Advanced reperfusion strategies for patients with out-of-hospital cardiac arrest and refractory ventricular fibrillation (ARREST): a phase 2, single centre, open-label, randomised controlled trial. Lancet. 2020;396(10265):1807-1816. doi:10.1016/S0140-6736(20)32338-2
26.
WilkoffBLFilippatosGLeclercqC, et al.Adaptive versus conventional cardiac resynchronisation therapy in patients with heart failure (AdaptResponse): a global, prospective, randomised controlled trial. Lancet. 2023;402(10408):1147-1157. doi:10.1016/S0140-6736(23)00912-1
27.
SáMPJacquemynXErtenO, et al.Long-term outcomes of sternal-sparing versus sternotomy approaches for mitral valve repair: meta-analysis of reconstructed time-to-event data. Innovations. 2023;18(2):167-174. doi:10.1177/15569845231166902
28.
AkowuahEFMaierRHHancockHC, et al.Minithoracotomy vs conventional sternotomy for mitral valve repair: a randomized clinical trial. JAMA. 2023;329(22):1957-1966. doi:10.1001/jama.2023.7800
29.
Escorel NetoACSáMPVan den EyndeJ, et al.Outcomes of cardiac surgical procedures performed by trainees versus consultants: a systematic review with meta-analysis. J Thorac Cardiovasc Surg. 2023;166(2):612-627.e35. doi:10.1016/j.jtcvs.2021.12.029
30.
RichterMJFortuniFAleneziF, et al.Imaging the right atrium in pulmonary hypertension: a systematic review and meta-analysis. J Heart Lung Transplant. 2023;42(4):433-446. doi:10.1016/j.healun.2022.11.007
31.
ThunbergCAGaitanBDGrewalARamakrishnaHStansburyLGGrigoreAM. Pulmonary hypertension in patients undergoing cardiac surgery: pathophysiology, perioperative management, and outcomes. J Cardiothorac Vasc Anesth. 2013;27(3):551-572. doi:10.1053/j.jvca.2012.07.017
MessasEIjsselmuidenATrifunović-ZamaklarD, et al.Treatment of severe symptomatic aortic valve stenosis using non-invasive ultrasound therapy: a cohort study. Lancet. 2023;402(10419):2317-2325. doi:10.1016/S0140-6736(23)01518-0
34.
BonowROGreenlandP. Population-wide trends in aortic stenosis incidence and outcomes. Circulation. 2015;131(11):969-971. doi:10.1161/CIRCULATIONAHA.115.014846
35.
MohiuddinMMSinghAKScobieL, et al.Graft dysfunction in compassionate use of genetically engineered pig-to-human cardiac xenotransplantation: a case report. Lancet. 2023;402(10399):397-410. doi:10.1016/S0140-6736(23)00775-4
36.
GriffithBPGoerlichCESinghAK, et al.Genetically modified porcine-to-human cardiac xenotransplantation. N Engl J Med. 2022;387(1):35-44. doi:10.1056/NEJMoa2201422
37.
CooperDKCCozziE. Clinical pig heart xenotransplantation—where do we go from here?Transpl Int. 2024;37:12592. doi:10.3389/ti.2024.12592
38.
SchroderJNPatelCBDeVoreAD, et al.Transplantation outcomes with donor hearts after circulatory death. N Engl J Med. 2023;388(23):2121-2131. doi:10.1056/NEJMoa2212438
39.
ArdehaliAEsmailianFDengM, et al.Ex-vivo perfusion of donor hearts for human heart transplantation (PROCEED II): a prospective, open-label, multicentre, randomised non-inferiority trial. Lancet. 2015;385(9987):2577-2584. doi:10.1016/S0140-6736(15)60261-6
40.
AnttilaVSarasteAKnuutiJ, et al.Direct intramyocardial injection of VEGF mRNA in patients undergoing coronary artery bypass grafting. Mol Ther. 2023;31(3):866-874. doi:10.1016/j.ymthe.2022.11.017
SpadaccioCNennaARoseD, et al.The role of angiogenesis and arteriogenesis in myocardial infarction and coronary revascularization. J Cardiovasc Transl Res. 2022;15(5):1024-1048. doi:10.1007/s12265-022-10241-0
43.
FangELiuXLiM, et al.Advances in COVID-19 mRNA vaccine development. Signal Transduct Targeted Ther. 2022;7(1):94. doi:10.1038/s41392-022-00950-y
