Since the days of the first cardiac surgical operations in the previous century, myocardial preservation has been an essential component of the successful outcome of these procedures. Although many different techniques to achieve myocardial preservation and modulation have been described in the past 50 years, this review focuses on the use of glucose, insulin, and potassium (GIK) and its effect on ischemic and postischemic myocardium.
Sodi-Pallares D, Testelli MR, Fishleder BL, et al. Effects of an intravenous infusion of a potassium-glucose-insulin solution on the electrocardiographic signs of myocardial infarction. Am J Cardiol. 1962;5:166-181.
2.
Malmberg K, Rydén L, Efendic S, et al. Randomized trial of insulin-glucose infusion followed by subcutaneous insulin treatment in diabetic patients with acute myocardial infarction (DIGAMI-study): effects on mortality at 1 year. J Am Coll Cardiol. 1995;26:57-65.
3.
Fath-Ordoubadi F, Beatt KJ. Glucose-insulin-potassium therapy for treatment of acute myocardial infarction. An overview of randomized, placebo-controlled trials. Circulation. 1997;96:1152-1156.
4.
Diaz R, Paolasso EA, Piegas LS, et al. Metabolic modulation of acute myocardial infarction. The ECLA glucose-insulin-potassium pilot trial. Circulation. 1998; 98:2227-2234.
5.
van der Horst ICC, Zijlstra F, van't Hof AW, et al. Glucose-insulin-potassium infusion in patients treated with primary angioplasty for acute myocardial infarction: the glucose-insulin-potassium study: a randomized trial. J Am Coll Cardiol. 2003;42:784-791.
6.
Mehta SR, Yusuf S, Diaz R, et al. Effect of glucose-insulin-potassium infusion on mortality in patients with acute ST-segment elevation myocardial infarction: the CREATE-ECLA randomized controlled trial. JAMA. 2005;293: 437-446.
7.
Malmberg K, Ryden L, Wedel H, et al. Intense metabolic control by means of insulin in patients with diabetes mellitus and acute myocardial infarction (DIGAMI 2): effects on mortality and morbidity. Eur Heart J. 2005;26:650-661.
8.
van den Berghe G.Insulin vs. strict blood glucose control to achieve a survival benefit after AMI?. Eur Heart J. 2005;26:639-641.
9.
Apstein CS, Opie LH. A challenge to the metabolic approach to myocardial ischaemia. Eur Heart J. 2005;26: 956-959.
10.
Merhige ME, Ekas R, Mossberg K, Taegtmeyer H, Gould KL. Catecholamine stimulation, substrate competition, and myocardial glucose uptake in conscious dogs assessed with positron emission tomography. Circ Res. 1987;61(suppl II):II124-II129.
11.
Svedjeholm R, Huljebrant I, Håkanson E, Vanhanen I.Glutamate and high dose Glucose-Insulin-Potassium (GIK) in the treatment of severe cardiac failure after cardiac operations. Ann Thorac Surg. 1995;59:S23-S30.
Taegtmeyer H, Goodwin GW, Doenst T, Frasier OH. Substrate metabolism as a determinant for postischemic functional recovery of the heart. Am J Cardiol. 1997; 80:3A-10A.
14.
Van den Berghe G, Wouters P, Weekers F, et al. Intensive insulin therapy in critically ill patients. N Eng J Med. 2001;345:1359-1367.
15.
Lazar H, Chipkin S, Philippides G, Bao Y, Apstein C.Glucose-Insulin-Potassium solutions improve outcomes in diabetics who have coronary artery operations. Ann Thorac Surg. 2000;70:145-150.
16.
Lazar HL, Chipkin SR, Fitzgerald CA. Tight glycemic control in diabetic coronary artery bypass graft patients improves perioperative outcomes and decreases recurrent ischemic events. Circulation. 2004;09:1497-1502.
Jeschke MG, Klein D, Bolder U, et al. Insulin attenuates the systemic inflammatory response in endotoxemic rats. Endocrinology. 2004;145:4084-4093.
19.
Chaudhuri A, Janicke D, Wilson MF, et al. Anti-inflammatory and profibrinolytic effect of insulin in acute ST-segment-elevation myocardial infarction. Circulation. 2004;109:849-854.
20.
Visser L, Zuurbier CJ, Hoek FJ, et al. Glucose, insulin and potassium applied as a perioperative hyperinsulinemic normoglycemic clamp: effects on the inflammatory response during coronary artery surgery. Br J Anesth. 2005;95:448-457.
21.
Marfella R, Siniscalchi M, Esposito K, et al. Effects of stress hyperglycemia on acute myocardial infarction: role of inflammatory immune process in functional cardiac outcome. Diabetes Care. 2003;26:3129-3135.
22.
Esposito K, Nappo F, Marfella R, et al. Inflammatory cytokine concentrations are acutely increased by hyperglycemia in humans: role of oxidative stress. Circulation. 2002;106:2067-2072.
23.
Capes SE, Hunt D, Malmberg K, Gerstein HC. Stress hyperglycemia and increased risk of death after myocardial infarction in patients with and without diabetes: a systematic overview. Lancet. 2000;335:773-778.
24.
Zindrou D, Taylor KN, Bagger JP. Admission plasma glucose: independent risk factor in non-diabetic women after coronary artery bypass grafting. Diabetes Care. 2001;24: 1634-1639.
25.
Abdelhadi RH, Gurm HS, Van Wagoner DR, Chung MK. Relation of an exaggerated rise in white blood cells after coronary bypass or cardiac valve surgery to development of atrial fibrillation postoperatively. Am J Cardiol. 2004; 93:1176-1178.
26.
Kirtane AJ, Bui A, Murphy SA, Barron HV, Gibson CM. Association of peripheral neutrophilia with adverse angiographic outcomes in ST-elevation myocardial infarction. Am J Cardiol. 2005;95:159-160.
