This study extends long-term predictive research on ADHD by including both neuropsychological and symptom measures at baseline in adolescence as predictors of diagnostic persistence 25 years later.
Methods:
Nineteen males with ADHD and 26 healthy controls (HC; M/F = 13/13), were assessed in adolescence and 25 years later. Measurements at baseline included a comprehensive test battery measuring eight neuropsychological domains, an IQ estimate, the Child Behavior Checklist (CBCL), and the Global Assessment Scale of Symptoms. Differences between ADHD Retainers, Remitters, and HC were calculated with ANOVAs, and potential predictions of differences in the ADHD group by linear regression analyses.
Results:
Eleven (58%) participants retained their ADHD diagnoses at follow-up. Motor Coordination and Visual perception at baseline predicted diagnosis at follow-up. CBCL Attention problems at baseline in the ADHD group predicted variance in diagnostic status.
Conclusion:
Lower-order neuropsychological functions related to motor function and perception are important long-time predictors of persistence of ADHD.
AchenbachT. M.RescorlaL. A. (2003). Manual for the ASEBA adult forms & profiles. University of Vermont, Research Center for Children, Youth.
3.
Agnew-BlaisJ. C.PolanczykG. V.DaneseA.WertzJ.MoffittT. E.ArseneaultL. (2016). Evaluation of the persistence, remission, and emergence of attention-deficit/hyperactivity disorder in young adulthood. JAMA Psychiatry, 73(7), 713–720.
4.
American Psychiatric Association. (1987). Diagnostic and statistical manual of mental disorders (DSM-III-R) (3rd rev.). American Psychiatric Association.
5.
American Psychiatric Association. (2000). Diagnostic and statistical manual of mental disorders (DSM-IV) (4th Text rev.). American Psychiatric Association.
BakkerD. J.Van Der VlugtH.ClaushuisM. (1978). The reliability of dichotic ear asymmetry in normal children. Neuropsychologia, 16(6), 753–757.
8.
BanerjeeA.ChitnisU. B.JadhavS. L.BhawalkarJ. S.ChaudhuryS. (2009). Hypothesis testing, type I and type II errors. Industrial Psychiatry Journal, 18(2), 127–131.
9.
BiedermanJ.FaraoneS. V. (2004). The Massachusetts General Hospital studies of gender influences on attention-deficit/hyperactivity disorder in youth and relatives. Psychiatric Clinics of North America, 27(2), 225–232. https://doi.org/10.1016/j.psc.2003.12.004
10.
BiedermanJ.FaraoneS. V.WeberW.RussellR. L.RaterM.ParkK. S. (1997). Correspondence between DSM-III-R and DSM-IV attention-deficit/hyperactivity disorder. Journal of the American Academy of Child & Adolescent Psychiatry, 36(12), 1682–1687. https://doi.org/10.1097/00004583-199712000-00016
11.
BiedermanJ.PettyC. R.ClarkeA.LomedicoA.FaraoneS. V. (2011). Predictors of persistent ADHD: An 11-year follow-up study. Journal of Psychiatric Research, 45(2), 150–155. https://doi.org/10.1016/j.jpsychires.2010.06.009
12.
CardilloR.VioC.MammarellaI. C. (2020). A comparison of local-global visuospatial processing in autism spectrum disorder, nonverbal learning disability, ADHD and typical development. Research in Developmental Disabilities, 103, 103682.
13.
CayeA.RochaT. B.AnselmiL.MurrayJ.MenezesA. M.BarrosF. C.GonçalvesH.WehrmeisterF.JensenC. M.SteinhausenH.-C.SwansonJ. M.KielingC.RohdeL. A. (2016). Attention-deficit/hyperactivity disorder trajectories from childhood to young adulthood: Evidence from a birth cohort supporting a late-onset syndrome. JAMA Psychiatry, 73(7), 705–712. https://doi.org/10.1001/jamapsychiatry.2016.0383
14.
CayeA.SpadiniA. V.KaramR. G.GrevetE. H.RovarisD. L.BauC. H. D.RohdeL. A.KielingC. (2016). Predictors of persistence of ADHD into adulthood: A systematic review of the literature and meta-analysis. European Child & Adolescent Psychiatry, 25(11), 1151–1159. https://doi.org/10.1007/s00787-016-0831-8
15.
CharterR. A.WebsterJ. S. (1997). Psychometric structure of the seashore rhythm test. The Clinical Neuropsychologist, 11(2), 167–173. https://doi.org/10.1080/13854049708407046
16.
CheungC. H.RijdijkF.McLoughlinG.FaraoneS. V.AshersonP.KuntsiJ. (2015). Childhood predictors of adolescent and young adult outcome in ADHD. Journal of Psychiatric Research, 62, 92–100. https://doi.org/10.1016/j.jpsychires.2015.01.011
17.
CoghillD. R.SethS.MatthewsK. (2014). A comprehensive assessment of memory, delay aversion, timing, inhibition, decision making and variability in attention deficit hyperactivity disorder: Advancing beyond the three-pathway models. Psychological Medicine, 44(9), 1989–2001. https://doi.org/10.1017/S0033291713002547
18.
DammeT. V.SimonsJ.SabbeB.van WestD. (2015). Motor abilities of children and adolescents with a psychiatric condition: A systematic literature review. World Journal of Psychiatry, 5(3), 315–329. https://doi.org/10.5498/wjp.v5.i3.315
19.
DelisD. C.KramerJ. H.KaplanE.ThompkinsB. A. O. (1987). CVLT: California verbal learning test-adult version: Manual. Psychological Corporation.
EgelandJ.LøvstadM.NorupA.NyboT.PerssonB. A.RiveraD. F.SchankeA.-K.SigurdardottirS.Arango-LasprillaJ. C. (2016). Following international trends while subject to past traditions: Neuropsychological test use in the Nordic countries. The Clinical Neuropsychologist, 30(Supp. 1), 1479–1500.
22.
EgelandJ.UelandT.JohansenS. (2012). Central processing energetic factors mediate impaired motor control in ADHD combined subtype but Not in ADHD inattentive subtype. Journal of Learning Disabilities, 45(4), 361–370. https://doi.org/10.1177/0022219411407922
23.
EmeR. (2017). A review of the most recent longitudinal studies of ADHD. Journal of Memory Disorders and Rehabilitation, 2(1), 1004.
24.
EndicottJ.SpitzerR. L.FleissJ. L.CohenJ. (1976). The global assessment scale: A procedure for measuring overall severity of psychiatric disturbance. Archives of General Psychiatry, 33(6), 766–771.
25.
FrankeB.MicheliniG.AshersonP.BanaschewskiT.BilbowA.BuitelaarJ. K.CormandB.FaraoneS. V.GinsbergY.HaavikJ.KuntsiJ.LarssonH.LeschK.-P.Ramos-QuirogaA.RéthelyiJ. M.RibasesM.ReifA. (2018). Live fast, die young? A review on the developmental trajectories of ADHD across the lifespan. European Neuropsychopharmacology, 28(10), 1059–1088. https://doi.org/10.1016/j.euroneuro.2018.08.001
26.
FrazierT. W.DemareeH. A.YoungstromE. A. (2004). Meta-analysis of intellectual and neuropsychological test performance in attention-deficit/hyperactivity disorder. Neuropsychology, 18(3), 543–555. https://doi.org/10.1037/0894-4105.18.3.543
27.
GaoQ.QianY.HeX.-X.SunL.ChangW.-L.LiY.-L.CaoQ.-J.WangY.-F.QianQ.-J. (2015). Childhood predictors of persistent ADHD in early adulthood: Results from the first follow-up study in China. Psychiatry Research, 230(3), 905–912. https://doi.org/10.1016/j.psychres.2015.11.025
28.
GillbergC. (1983). Perceptual, motor and attentional deficits in Swedish primary school children. Some child psychiatric aspects. Journal of Child Psychology and Psychiatry, 24(3), 377–403.
GillbergC. (2003b). Deficits in attention, motor control, and perception: A brief review. Archives of Disease in Childhood, 88(10), 904–910. https://doi.org/10.1136/adc.88.10.904
31.
GillbergC. (2010). The ESSENCE in child psychiatry: Early symptomatic syndromes eliciting neurodevelopmental clinical examinations. Research in Developmental Disabilities, 31(6), 1543–1551.
32.
GoldsteinG.WatsonJ. R. (1989). Test-retest reliability of the halstead-reitan battery and the WAIS in a neuropsychiatric population. Clinical Neuropsychologist, 3(3), 265–272. https://doi.org/10.1080/13854048908404088
33.
GreenM. F.NuechterleinK. H.MintzJ. (1994). Backward masking in Schizophrenia and Mania: II. specifying the visual channels. Archives of General Psychiatry, 51(12), 945–951. https://doi.org/10.1001/archpsyc.1994.03950120017004
34.
HarperL. V.KraftR. H. (1986). Lateralization of receptive language in preschoolers: Test–retest reliability in a dichotic listening task. Developmental Psychology, 22(4), 553–556.
35.
HarrisL.LeeV. K.ThompsonE. H.KrantonR. (2016). Exploring the generalization process from past behavior to predicting future behavior. Journal of Behavioral Decision Making, 29(4), 419–436.
HudziakJ. J.CopelandW.StangerC.WadsworthM. (2004). Screening for DSM-IV externalizing disorders with the child behavior checklist: A receiver-operating characteristic analysis. Journal of Child Psychology and Psychiatry, 45(7), 1299–1307. https://doi.org/10.1111/j.1469-7610.2004.00314.x
38.
HugdahlK.AnderssonL. (1986). The “forced-attention paradigm” in dichotic listening to CV-syllables: A comparison between adults and children. Cortex, 22(3), 417–432. https://doi.org/10.1016/S0010-9452(86)80005-3
39.
KaiserM. L.SchoemakerM. M.AlbaretJ. M.GeuzeR. H. (2015). What is the evidence of impaired motor skills and motor control among children with attention deficit hyperactivity disorder (ADHD)? Systematic review of the literature. Research in Developmental Disabilities, 36, 338–357. https://doi.org/10.1016/j.ridd.2014.09.023
40.
KesslerR. C.AdlerL.AmesM.DemlerO.FaraoneS.HiripiE.HowesM. J.JinR.SecnikK.SpencerT.UstunT. B.WaltersE. E. (2005). The World Health Organization adult ADHD self-report scale (ASRS): A short screening scale for use in the general population. Psychological Medicine, 35(2), 245–256. https://doi.org/10.1017/S0033291704002892
41.
KesslerR. C.AdlerL.BarkleyR.BiedermanJ.ConnersC. K.FaraoneS. V.GreenhillL. L.JaegerS.SecnikK.SpencerT.ÜstünT. B.ZaslavskyA. M. (2005). Patterns and predictors of attention-deficit/hyperactivity disorder persistence into adulthood: Results from the National Comorbidity Survey Replication. Biological Psychiatry, 57(11), 1442–1451. https://doi.org/10.1016/j.biopsych.2005.04.001
KimuraD. (1980). Sex differences in intrahemispheric organization of speech. Behavioral and Brain Sciences, 3(2), 240–241. https://doi.org/10.1017/S0140525X0000457X
44.
LampertT. L.PolanczykG.TramontinaS.MardiniV.RohdeL. A. (2004). Diagnostic performance of the CBCL-attention problem scale as a screening measure in a sample of Brazilian children with ADHD. Journal of Attention Disorders, 8(2), 63–71. https://doi.org/10.1177/108705470400800204
45.
LaraC.FayyadJ.de GraafR.KesslerR. C.Aguilar-GaxiolaS.AngermeyerM.DemytteneareK.de GirolamoG.HaroJ. M.JinR.KaramE. G.LépineJ.-P.MoraM. E. M.OrmelJ.Posada-VillaJ.SampsonN. (2009). Childhood predictors of adult attention-deficit/hyperactivity disorder: Results from the World Health Organization World Mental Health Survey Initiative. Biological Psychiatry, 65(1), 46–54. https://doi.org/10.1016/j.biopsych.2008.10.005
46.
LenzD.KrauelK.FlechtnerH.-H.SchadowJ.HinrichsH.HerrmannC. S. (2010). Altered evoked gamma-band responses reveal impaired early visual processing in ADHD children. Neuropsychologia, 48(7), 1985–1993. https://doi.org/10.1016/j.neuropsychologia.2010.03.019
LuoY.WeibmanD.HalperinJ. M.LiX. (2019). A review of heterogeneity in attention deficit/hyperactivity disorder (ADHD). Frontiers in Human Neuroscience, 13, 42. https://doi.org/10.3389/fnhum.2019.00042
49.
MatthewsC. G.KloveH. (1964). Instruction manual for the adult neuropsychology test battery (Vol. 36). University of Wisconsin Medical School.
50.
MontanoD. E.KasprzykD. (2015). Theory of reasoned action, theory of planned behavior, and the integrated behavioral model. In KarenG.BarbaraR.ViswanathK. (Eds.), Health behavior: Theory, research and practice (pp. 95–124). Jossey-Bass.
51.
MostertJ. C.OnninkA. M. H.KleinM.DammersJ.HarneitA.SchultenT.van HulzenK. J. E.KanC. C.Slaats-WillemseD.BuitelaarJ. K.FrankeB.HoogmanM. (2015). Cognitive heterogeneity in adult attention deficit/hyperactivity disorder: A systematic analysis of neuropsychological measurements. European Neuropsychopharmacology, 25(11), 2062–2074. https://doi.org/10.1016/j.euroneuro.2015.08.010
52.
NøvikT. S. (1999). Validity of the child behaviour checklist in a Norwegian sample. European Child and Adolescent Psychiatry, 8(4), 247–254.
53.
OltmannsT. F.NealeJ. M. (1975). Schizophrenic performance when distractors are present: Attentional deficit or differential task difficulty?Journal of Abnormal Psychology, 84(3), 205–209. https://doi.org/10.1037/h0076721
54.
PanagiotidiM.PaulO.TomS. (2017). Increased microsaccade rate in individuals with ADHD traits. Journal of Eye Movement Research, 10(1), 1–9
55.
ReitanR. M.WolfsonD. (1985). The Halstead-Reitan neuropsychological test battery: Theory and clinical interpretation (Vol. 4). Neuropsychology Press.
56.
RíosM.PeriáñezJ. A.Muñoz-CéspedesJ. M. (2004). Attentional control and slowness of information processing after severe traumatic brain injury. Journal of Brain Injury, 18(3), 257–272.
57.
RoyA.HechtmanL.ArnoldL. E.SibleyM. H.MolinaB. S. G.SwansonJ. M.HowardA. L. & MTA Cooperative Group. (2016). Childhood factors affecting persistence and desistence of attention-deficit/hyperactivity disorder symptoms in adulthood: Results from the MTA. Journal of the American Academy of Child & Adolescent Psychiatry, 55(11), 937–944.e934. https://doi.org/10.1016/j.jaac.2016.05.027
58.
SattlerJ. M.DumontR. (2004). Assessment of children: WISC-IV and WPPSI-III. Jerome M. Sattler, Publisher, Inc.
59.
SeashoreC. E.LewisD.SaetveitJ. G. (1960). Seashore measure of musical talents. Manual. Psychological Corporation.
60.
SheehanD. V.LecrubierY.JanavsJ.KnappE.WeillerE. (1994). Mini international neuropsychiatric interview (MINI). University of South Florida Institute for Research in Psychiatry.
61.
SjöwallD.BackmanA.ThorellL. B. (2015). Neuropsychological heterogeneity in preschool ADHD: Investigating the interplay between cognitive, affective and motivation-based forms of regulation. Journal of Abnormal Child Psychology, 43(4), 669–680.
62.
SkoganA. H.OerbeckB.ChristiansenC.LandeH. L.EgelandJ. (2018). Updated developmental norms for fine motor functions as measured by finger tapping speed and the Grooved Pegboard Test. Developmental Neuropsychology, 43(7), 551–565.
63.
SperlingG. (1965). Temporal and spatial visual masking. I. Masking by impulse flashes. Journal of the Optical Society of America, 55(5), 541–559.
64.
SpreenO.StraussE. (1991). Controlled oral word association (word fluency). A compendium of neuropsychological tests. Oxford University Press, pp. 219–227.
65.
TorgalsbøenB. R.ZeinerP.ØieM. G. (2021). Pre-attention and working memory in ADHD: A 25-year follow-up study. Journal of Attention Disorders, 25(7), 895–905.
66.
van LieshoutM.LumanM.BuitelaarJ.RommelseN. N.OosterlaanJ. (2013). Does neurocognitive functioning predict future or persistence of ADHD? A systematic review. Clinical Psychology Review, 33(4), 539–560. https://doi.org/10.1016/j.cpr.2013.02.003
67.
van LieshoutM.LumanM.TwiskJ. W.FaraoneS. V.HeslenfeldD. J.HartmanC. A.HoekstraP. J.FrankeB.BuitelaarJ. K.RommelseN. N. J.OosterlaanJ. (2017). Neurocognitive predictors of ADHD outcome: A 6-year follow-up study. Journal of Abnormal Child Psychology, 45(2), 261–272. https://doi.org/10.1007/s10802-016-0175-3
68.
WatembergN.WaiserbergN.ZukL.Lerman-SagieT. (2007). Developmental coordination disorder in children with attention-deficit–hyperactivity disorder and physical therapy intervention. Developmental Medicine & Child Neurology, 49(12), 920–925. https://doi.org/10.1111/j.1469-8749.2007.00920.x
69.
WechslerD. (1974). Manual for the Wechsler intelligence scale for children, revised. Psychological Corporation.
70.
WenderP. H.ReimherrF. W.WoodD.WardM. (1985). A controlled study of methylphenidate in the treatment of attention deficit disorder, residual type, in adults. American Journal of Psychiatry, 142(5), 547–552. https://doi.org/10.1176/ajp.142.5.547
71.
ØieM.RundB. R. (1999). Neuropsychological deficits in adolescent-onset schizophrenia compared with attention deficit hyperactivity disorder. American Journal of Psychiatry, 156(8), 1216–1222. https://doi.org/10.1176/ajp.156.8.1216
72.
ØieM.RundB. R.SundetK.BryhnG. (1998). Auditory laterality and selective attention: Normal performance in patients with early-onset schizophrenia. Schizophrenia Bulletin, 24(4), 643–652. https://doi.org/10.1093/oxfordjournals.schbul.a033356
73.
ØieM.SundetK.RundB. R. (2010). Neurocognitive decline in early-onset schizophrenia compared with ADHD and normal controls: Evidence from a 13-year follow-up study. Schizophrenia Bulletin, 36(3), 557–565. https://doi.org/10.1093/schbul/sbn127
74.
ØieM.SundetK.UelandT. (2011). Neurocognition and functional outcome in early-onset schizophrenia and attention-deficit/hyperactivity disorder: A 13-year follow-up. Neuropsychology, 25(1), 25–35. https://doi.org/10.1037/a0020855
75.
ØieM. G.SundetK. S.HaugE.ZeinerP.KlungsøyrO.RundB. R. (2021). Cognitive performance in early-onset Schizophrenia and attention-deficit/hyperactivity disorder: A 25-year follow-up study. Frontiers in Psychology, 11. Advance online publication. https://doi.org/10.3389/fpsyg.2020.606365
