Objective: This study’s objective is to differentiate possible ADHD syndromes on the basis of symptom trajectories, prognosis, and associated clinical features in a high-risk cohort. Method: Latent class analysis of inattentive (IA) and hyperactive–impulsive (HI) symptoms in 387 non-disabled members of a regional low birthweight/preterm birth cohort who were evaluated for ADHD at 6, 9, and 16 years. Adolescent functional outcomes and other clinical features were examined across the classes. Results: Three latent classes were identified: unaffected (modest IA and HI symptom prevalences at six, remitting by nine), school age limited (relatively high IA and HI symptom prevalences at six and nine, declining by 16), and persistent inattentive (high IA and HI prevalences at six and nine, with high IA levels persisting to 16). The persistent inattentive class was distinctively associated with poor functioning, motor problems, other psychiatric disorders, and social difficulties as indexed by a positive screen for autism spectrum disorder at 16. Conclusion: These findings differentiate a potential persistent inattentive syndrome relevant to ADHD evaluation and treatment.
Aarnoudse-MoensC. S.Weisglas-KuperusN.van GoudoeverJ. B.OosterlaanJ. (2009). Meta-analysis of neurobehavioral outcomes in very preterm and/or very low birth weight children. Pediatrics, 124, 717-728. doi:10.1542/peds.2008-2816
2.
AcostaM. T.CastellanosF. X.BoltonK. L.BalogJ. Z.EagenP.NeeL.. . . MuenkeM. (2008). Latent class subtyping of attention-deficit/hyperactivity disorder and comorbid conditions. Journal of the American Academy of Child & Adolescent Psychiatry, 47, 797-807. doi:10.1097/CHI.0b013e318173f70b
3.
American Psychiatric Association. (1987). Diagnostic and statistical manual of mental disorders (3rd ed., Rev.). Washington, DC: Author.
4.
American Psychiatric Association. (1994). Diagnostic and statistical manual of mental disorders (4th ed.). Washington, DC: Author.
5.
American Psychiatric Association. (2000). Diagnostic and statistical manual of mental disorders (4th ed., text rev.). Washington, DC: Author.
6.
American Psychiatric Association. (2013). Diagnostic and statistical manual of mental disorders (5th ed.). Arlington, VA: American Psychiatric Publishing.
7.
ArnoldL. E.GanocyS. J.MountK.YoungstromE. A.FrazierT. W.FristadM.. . . MarshL. (2014). Three-year latent class trajectories of Attention-Deficit/Hyperactivity Disorder (ADHD) symptoms in a clinical sample not selected for ADHD. Journal of the American Academy of Child & Adolescent Psychiatry, 53, 745-760.
8.
BalazsJ.MiklosiM.KeresztenyA.DallosG.GadorosJ. (2014). Attention-deficit hyperactivity disorder and suicidality in a treatment naive sample of children and adolescents. Journal of Affective Disorders, 152-154, 282-287. doi:10.1016/j.jad.2013.09.026
9.
BeckA. T.WardC. H.MendelsonM.MockJ.ErbaughJ. (1961). An inventory for measuring depression. Archives of General Psychiatry, 4, 561-571.
10.
BerumentS. K.RutterM.LordC.PicklesA.BaileyA. (1999). Autism screening questionnaire: Diagnostic validity. British Journal of Psychiatry, 175, 444-451.
11.
BiedermanJ.MickE.FaraoneS. V. (2000). Age-dependent decline of symptoms of attention deficit hyperactivity disorder: Impact of remission definition and symptom type. American Journal of Psychiatry, 157, 816-818.
12.
BiedermanJ.PettyC. R.ClarkeA.LomedicoA.FaraoneS. V. (2011). Predictors of persistent ADHD: An 11-year follow-up study. Journal of Psychiatric Research, 45, 150-155.
13.
BirdH. R.ShafferD.FisherP.GouldM. S.StaghezzaB.ChenJ. Y.HovenC. (1993). The Columbia-Impairment-Scale (Cis)—Pilot findings on a measure of global impairment for children and adolescents. International Journal of Methods in Psychiatric Research, 3, 167-176.
14.
ChenQ.SjolanderA.RunesonB.D’OnofrioB. M.LichtensteinP.LarssonH. (2014). Drug treatment for attention-deficit/hyperactivity disorder and suicidal behaviour: Register based study. British Medical Journal, 348, Article g3769. doi:10.1136/bmj.g3769
15.
CooperM.MartinJ.LangleyK.HamshereM.ThaparA. (2014). Autistic traits in children with ADHD index clinical and cognitive problems. European Child & Adolescent Psychiatry, 23, 23-34. doi:10.1007/s00787-013-0398-6
16.
CopelandW. E.AdairC. E.SmetaninP.StiffD.BrianteC.ColmanI.. . . AngoldA. (2013). Diagnostic transitions from childhood to adolescence to early adulthood. The Journal of Child Psychology and Psychiatry, 54, 791-799. doi:10.1111/jcpp.12062
17.
CostelloE. J.CopelandW.AngoldA. (2011). Trends in psychopathology across the adolescent years: What changes when children become adolescents, and when adolescents become adults?Journal of Child Psychology and Psychiatry, 52, 1015-1025. doi:10.1111/j.1469-7610.2011.02446.x
18.
EhlersS.GillbergC.WingL. (1999). A screening questionnaire for Asperger syndrome and other high-functioning autism spectrum disorders in school age children. Journal of Autism and Developmental Disorders, 29, 129-141.
19.
FaraoneS. V.BiedermanJ.MickE. (2006). The age-dependent decline of attention deficit hyperactivity disorder: A meta-analysis of follow-up studies. Psychological Medicine, 36, 159-165. doi:10.1017/S003329170500471X
20.
FernellE.GillbergC. (2012). Preterm birth, ADHD and the ESSENCE in adult psychiatry. Acta Paediatrica, 101, e568-569. doi:10.1111/apa.12026
21.
FredriksenM.DahlA.MartinsenE.KlungsoyrO.FaraoneS. V.PeleikisD. (2014). Childhood and persistent ADHD symptoms associated with educational failure and long-term occupational disability in adult ADHD. ADHD Attention Deficit and Hyperactivity Disorders, 6, 87-99. doi:10.1007/s12402-014-0126-1
22.
GilgerJ. W.KaplanB. J. (2001). Atypical brain development: A conceptual framework for understanding developmental learning disabilities. Developmental Neuropsychology, 20, 465-481. doi:10.1207/S15326942DN2002_2
23.
GillbergC. (2010). The ESSENCE in child psychiatry: Early symptomatic syndromes eliciting neurodevelopmental clinical examinations. Research in Developmental Disabilities, 31, 1543-1551. doi:10.1016/j.ridd.2010.06.002
24.
Groen-BlokhuisM. M.MiddeldorpC. M.van BeijsterveldtC. E.BoomsmaD. I. (2011). Evidence for a causal association of low birth weight and attention problems. Journal of the American Academy of Child & Adolescent Psychiatry, 50, 1247-1254.e2. doi:10.1016/j.jaac.2011.09.007
25.
GustafssonP.KerekesN.AnckarsaterH.LichtensteinP.GillbergC.RastamM. (2014). Motor function and perception in children with neuropsychiatric and conduct problems: Results from a population based twin study. Journal of Neurodevelopmental Disorders, 6, Article 11. doi:10.1186/1866-1955-6-11
26.
GuzeS. B. (1970). The need for toughmindedness in psychiatric thinking. Southern Medical Journal, 63, 662-671.
27.
HackM.TaylorH. G.SchluchterM.AndreiasL.DrotarD.KleinN. (2009). Behavioral outcomes of extremely low birth weight children at age 8 years. Journal of Developmental & Behavioral Pediatrics, 30, 122-130. doi:10.1097/DBP.0b013e31819e6a16
28.
HammernessP.JoshiG.DoyleR.GeorgiopoulosA.GellerD.SpencerT.. . . BiedermanJ. (2013). Do stimulants reduce the risk for cigarette smoking in youth with attention-deficit hyperactivity disorder? A prospective, long-term, open-label study of extended-release methylphenidate. The Journal of Pediatrics, 162, 22-27.e22. doi:10.1016/j.jpeds.2012.06.046
29.
HinshawS. P.OwensE. B.SamiN.FargeonS. (2006). Prospective follow-up of girls with attention-deficit/hyperactivity disorder into adolescence: Evidence for continuing cross-domain impairment. Journal of Consulting and Clinical Psychology, 74, 489-499. doi:10.1037/0022-006X.74.3.489
30.
JaekelJ.WolkeD.BartmannP. (2013). Poor attention rather than hyperactivity/impulsivity predicts academic achievement in very preterm and full-term adolescents. Psychological Medicine, 43, 183-196. doi:10.1017/S0033291712001031
31.
JensenC. M.SteinhausenH. C. (2015). Comorbid mental disorders in children and adolescents with attention-deficit/hyperactivity disorder in a large nationwide study. Attention Deficit and Hyperactivity Disorders, 7, 27-38. doi:10.1007/s12402-014-0142-1
32.
JensenP. S.ArnoldL. E.SwansonJ. M.VitielloB.AbikoffH. B.GreenhillL. L.. . . HurK. (2007). 3-year follow-up of the NIMH MTA study. Journal of the American Academy of Child & Adolescent Psychiatry, 46, 989-1002. doi:10.1097/CHI.0b013e3180686d48
33.
JohnsonS.HollisC.HennessyE.KochharP.WolkeD.MarlowN. (2011). Screening for autism in preterm children: Diagnostic utility of the Social Communication Questionnaire. Archives of Disease in Childhood, 96, 73-77. doi:10.1136/adc.2010.194795
34.
JohnsonS.HollisC.KochharP.HennessyE.WolkeD.MarlowN. (2010). Psychiatric disorders in extremely preterm children: Longitudinal finding at age 11 years in the EPICure study. Journal of the American Academy of Child & Adolescent Psychiatry, 49, 453-463.e451. doi:10.1097/00004583-201005000-00006
35.
JohnsonS.WolkeD. (2013). Behavioural outcomes and psychopathology during adolescence. Early Human Development, 89, 199-207. doi:10.1016/j.earlhumdev.2013.01.014
36.
KoyuncuA.ErtekinE.YukselC.Aslantas ErtekinB.CelebiF.BinbayZ.TukelR. (2014). Predominantly inattentive type of ADHD is associated with social anxiety disorder. Journal of Attention Disorders, 19, 856-864. doi:10.1177/1087054714533193
37.
LaheyB. B.WillcuttE. G. (2010). Predictive validity of a continuous alternative to nominal subtypes of attention-deficit/hyperactivity disorder for DSM-V. Journal of Clinical Child & Adolescent Psychology, 39, 761-775. doi:10.1080/15374416.2010.517173
38.
LambertW.BickmanL. (2004). Child & adolescent psychiatry: The “clock-setting” cure: How children’s symptoms might improve after ineffective treatment. Psychiatric Services, 55, 381-382.
39.
LarssonH.DilshadR.LichtensteinP.BarkerE. D. (2011). Developmental trajectories of DSM-IV symptoms of attention-deficit/hyperactivity disorder: Genetic effects, family risk and associated psychopathology. The Journal of Child Psychology and Psychiatry, 52, 954-963. doi:10.1111/j.1469-7610.2011.02379.x
40.
LjungT.ChenQ.LichtensteinP.LarssonH. (2014). Common etiological factors of attention-deficit/hyperactivity disorder and suicidal behavior: A population-based study in Sweden. JAMA: Psychiatry, 71, 958-964. doi:10.1001/jamapsychiatry.2014.363
41.
LoY.MendellN. R.RubinD. B. (2001). Testing the number of components in a normal mixture. Biometrika, 88, 767-778.
MolinaB. S.FloryK.HinshawS. P.GreinerA. R.ArnoldL. E.SwansonJ. M.. . . WigalT. (2007). Delinquent behavior and emerging substance use in the MTA at 36 months: Prevalence, course, and treatment effects. Journal of the American Academy of Child & Adolescent Psychiatry, 46, 1028-1040. doi:10.1097/chi.0b013e3180686d96
44.
MolinaB. S.HinshawS. P.SwansonJ. M.ArnoldL. E.VitielloB.JensenP. S.. . . HouckP. R. (2009). The MTA at 8 years: Prospective follow-up of children treated for combined-type ADHD in a multisite study. Journal of the American Academy of Child & Adolescent Psychiatry, 48, 484-500. doi:10.1097/CHI.0b013e31819c23d0
45.
MovsasT. Z.Pinto-MartinJ. A.WhitakerA. H.FeldmanJ. F.LorenzJ. M.KorzeniewskiS. J.. . . PanethN. (2013). Autism spectrum disorder is associated with ventricular enlargement in a low birth weight population. The Journal of Pediatrics, 163, 73-78. doi:10.1016/j.jpeds.2012.12.084
46.
MulliganA.AnneyR. J.O’ReganM.ChenW.ButlerL.FitzgeraldM.. . . GillM. (2009). Autism symptoms in attention-deficit/hyperactivity disorder: A familial trait which correlates with conduct, oppositional defiant, language and motor disorders. Journal of Autism and Developmental Disorders, 39, 197-209. doi:10.1007/s10803-008-0621-3
47.
MuthenL. K.MuthenB. O. (1998-2007). Mplus user’s guide (5th ed.). Los Angeles, CA: Muthen & Muthen.
48.
NiemannG.WakatJ. P.Krageloh-MannI.GroddW.MichaelisR. (1994). Congenital hemiparesis and periventricular leukomalacia: Pathogenetic aspects on magnetic resonance imaging. Developmental Medicine & Child Neurology, 36, 943-950.
49.
NosartiC.ReichenbergA.MurrayR. M.CnattingiusS.LambeM. P.YinL.. . . HultmanC. M. (2012). Preterm birth and psychiatric disorders in young adult life. Archives of General Psychiatry, 69(6), E1-E8. doi:10.1001/archgenpsychiatry.2011.1374
50.
O’SheaT. M.DowneyL. C.KubanK. K. (2013). Extreme prematurity and attention deficit: Epidemiology and prevention. Frontiers in Human Neuroscience, 7, 578. doi:10.3389/fnhum.2013.00578
51.
PapadopoulosN.RinehartN.BradshawJ. L.McGinleyJ. L. (2013). Brief report: Children with ADHD without co-morbid autism do not have impaired motor proficiency on the movement assessment battery for children. Journal of Autism and Developmental Disorders, 43, 1477-1482. doi:10.1007/s10803-012-1687-5
52.
PiekJ. P.PitcherT. M.HayD. A. (1999). Motor coordination and kinaesthesis in boys with attention deficit–hyperactivity disorder. Developmental Medicine & Child Neurology, 41, 159-165. doi:10.1111/j.1469-8749.1999.tb00575.x
53.
PingaultJ. B.TremblayR. E.VitaroF.CarbonneauR.GenoliniC.FalissardB.CoteS. M. (2011). Childhood trajectories of inattention and hyperactivity and prediction of educational attainment in early adulthood: A 16-year longitudinal population-based study. American Journal of Psychiatry, 168, 1164-1170. doi:10.1176/appi.ajp.2011.10121732
54.
Pinto-MartinJ. A.LevyS. E.FeldmanJ. F.LorenzJ. M.PanethN.WhitakerA. H. (2011). Prevalence of autism spectrum disorder in adolescents born weighing <2000 grams. Pediatrics, 128, 883-891. doi:10.1542/peds.2010-2846
55.
Pinto-MartinJ. A.PanethN.WitomskiT.SteinI.SchonfeldS.RosenfeldD.. . . SusserM. W. (1992). The central New Jersey neonatal brain haemorrhage study: Design of the study and reliability of ultrasound diagnosis. Paediatric and Perinatal Epidemiology, 6, 273-284. doi:10.1111/j.1365-3016.1992.tb00767.x
56.
Pinto-MartinJ. A.RioloS. A.CnaanA.HolzmanC.PanethN. (1995). Cranial ultrasound prediction of disabling and nondisabling cerebral palsy at age two in a low birth weight population. Pediatrics, 95, 249-254.
57.
Pinto-MartinJ. A.WhitakerA.FeldmanJ.CnaanA.ZhaoH.Rosen-BlochJ.. . . PanethN. (2004). Special education services and school performance in a regional cohort of low-birthweight infants at age nine. Paediatric and Perinatal Epidemiology, 18, 120-129.
58.
PoldermanT. J.BoomsmaD. I.BartelsM.VerhulstF. C.HuizinkA. C. (2010). A systematic review of prospective studies on attention problems and academic achievement. Acta Psychiatrica Scandinavica, 122, 271-284. doi:10.1111/j.1600-0447.2010.01568.x
59.
Ramos OlazagastiM. A.KleinR. G.MannuzzaS.BelskyE. R.HutchisonJ. A.Lashua-ShriftmanE. C.CastellanosF. X. (2013). Does childhood attention-deficit/hyperactivity disorder predict risk-taking and medical illnesses in adulthood?Journal of the American Academy of Child & Adolescent Psychiatry, 52, 153-162.e154. doi:10.1016/j.jaac.2012.11.012
60.
ReiersenA. M.ConstantinoJ. N.ToddR. D. (2008). Co-occurrence of motor problems and autistic symptoms in attention-deficit/hyperactivity disorder. Journal of the American Academy of Child & Adolescent Psychiatry, 47, 662-672. doi:10.1097/CHI.0b013e31816bff88
61.
RigbyK.SleeP. T. (1993). Dimensions of interpersonal relation among Australian children and implications for psychological well-being. The Journal of Social Psychology, 133, 33-42.
62.
RileyG. D. (1976). Riley motor problems inventory: Manual. Los Angeles, CA: Western Psychological Services.
63.
RutterM. (1982). Syndromes attributed to “minimal brain dysfunction” in childhood. American Journal of Psychiatry, 139, 21-33.
64.
RutterM. (1983). Behavioral studies: Questions and findings on the concept of a distinctive syndrome. In RutterM. (Ed.), Developmental neuropsychiatry (pp. 259-279). New York, NY: Guilford.
65.
SaigalS.HoultL. A.StreinerD. L.StoskopfB. L.RosenbaumP. L. (2000). School difficulties at adolescence in a regional cohort of children who were extremely low birth weight. Pediatrics, 105, 325-331.
66.
SaigalS.LambertM.RussC.HoultL. (2002). Self-esteem of adolescents who were born prematurely. Pediatrics, 109, 429-433.
67.
SaigalS.PinelliJ.HoultL.KimM. M.BoyleM. (2003). Psychopathology and social competencies of adolescents who were extremely low birth weight. Pediatrics, 111, 969-975.
68.
ShafferD.FisherP.DulcanM. K.Schwab-StoneM. E. (2000). NIMH Diagnostic Interview Schedule for Children IV (NIMH DISC-IV): Description, differences from previous versions, and reliability of some common diagnoses. Journal of the American Academy of Child & Adolescent Psychiatry, 39, 28-38.
69.
ShafferD.FisherP.LucasC. P. (1994). Diagnostic Interview Schedule for Children, Version 3 (DISC-3.0). New York: Division of Child and Adolescent Psychiatry, New York State Psychiatric Institute, Columbia University.
70.
ShafferD.FisherP.PiacentiniJ.Schwab-StoneM.WicksJ. (1989). Diagnostic Interview Schedule for Children (DISC-2.1P): Parent version. New York: Division of Child and Adolescent Psychiatry, New York State Psychiatric Institute.
71.
ShafferD.GouldM. S.BrasicJ.AmbrosiniP. J.FisherP.BirdH.AluwahliaS. (1983). A Children’s Global Assessment Scale (CGAS). Archives of General Psychiatry, 40, 1228-1231.
72.
ShafferD.GreenhillL. (1979). A critical note on the predictive validity of “the hyperkinetic syndrome.”Journal of Clinical Child & Adolescent Psychology, 20, 61-72.
73.
ShafferD.Schwab-StoneM.FisherP.CohenP.PiacentiniJ.DaviesM.. . . RegierD. (1993). The Diagnostic Interview Schedule for Children-Revised Version (DISC-R): I. Preparation, field testing, interrater reliability, and acceptability. Journal of the American Academy of Child & Adolescent Psychiatry, 32, 643-650.
74.
SparrowS. S.BallaD. A.CicchettiD. V. (1984). Vineland Adaptive Behavior Scales: Interview edition, survey form manual. Circle Pines, MN: American Guidance Service.
75.
SpencerT. J.FaraoneS. V.TarkoL.McDermottK.BiedermanJ. (2014). Attention-deficit/hyperactivity disorder and adverse health outcomes in adults. Journal of Nervous and Mental Disease, 202, 725-731. doi:10.1097/NMD.0000000000000191
76.
TaylorH. G. (2010). Persisting cognitive deficits in survivors of very low birthweight and their implications for adult functioning. Developmental Medicine & Child Neurology, 52, 1078-1079. doi:10.1111/j.1469-8749.2010.03773.x
TruwitC. L.BarkovichA. J.KochT. K.FerrieroD. M. (1992). Cerebral palsy: MR findings in 40 patients. American Journal of Neuroradiology, 13, 67-78.
79.
VisserS. N.DanielsonM. L.BitskoR. H.HolbrookJ. R.KoganM. D.GhandourR. M.. . . BlumbergS. J. (2014). Trends in the parent-report of health care provider-diagnosed and medicated attention-deficit/hyperactivity disorder: United States, 2003-2011. Journal of the American Academy of Child & Adolescent Psychiatry, 53, 34-46.e32. doi:10.1016/j.jaac.2013.09.001
80.
WashbrookE.PropperC.SayalK. (2013). Pre-school hyperactivity/attention problems and educational outcomes in adolescence: Prospective longitudinal study. The British Journal of Psychiatry, 203, 265-271. doi:10.1192/bjp.bp.112.123562
81.
WechslerD. (1991). WISC-III: Wechsler Intelligence Scale for Children. San Antonio, TX: Psychological Corporation.
82.
WechslerD. (1999). Wechsler Abbreviated Scale of Intelligence. San Antonio, TX: Psychological Corporation.
83.
WhitakerA. H.FeldmanJ. F.LorenzJ. M.McNicholasF.FisherP. W.ShenS.PanethN. (2011). Neonatal head ultrasound abnormalities in preterm infants and adolescent psychiatric disorders. Archives of General Psychiatry, 68, 742-752. doi:10.1001/archgenpsychiatry.2011.62
84.
WhitakerA. H.FeldmanJ. F.LorenzJ. M.ShenS.McNicholasF.NietoM.. . . PanethN. (2006). Motor and cognitive outcomes in nondisabled low-birth-weight adolescents: Early determinants. Archives of Pediatrics & Adolescent Medicine, 160, 1040-1046. doi:10.1001/archpedi.160.10.1040
85.
WhitakerA. H.FeldmanJ. F.Van RossemR.SchonfeldI. S.Pinto-MartinJ. A.TorreC.. . . PanethN. S. (1996). Neonatal cranial ultrasound abnormalities in low birth weight infants: Relation to cognitive outcomes at six years of age. Pediatrics, 98(4, Pt. 1), 719-729.
86.
WhitakerA. H.Van RossemR.FeldmanJ. F.SchonfeldI. S.Pinto-MartinJ. A.ToreC.. . . PanethN. (1997). Psychiatric outcomes in low-birth-weight children at age 6 years: Relation to neonatal cranial ultrasound abnormalities. Archives of General Psychiatry, 54, 847-856.
87.
WillcuttE. G.NiggJ. T.PenningtonB. F.SolantoM. V.RohdeL. A.TannockR.. . . LaheyB. B. (2012). Validity of DSM-IV attention deficit/hyperactivity disorder symptom dimensions and subtypes. Journal of Abnormal Psychology, 121, 991-1010. doi:10.1037/a0027347
88.
WolkeD.WaylenA.SamaraM.SteerC.GoodmanR.FordT.LambertsK. (2009). Selective drop-out in longitudinal studies and non-biased prediction of behaviour disorders. The British Journal of Psychiatry, 195, 249-256. doi:10.1192/bjp.bp.108.053751
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