Possible Age-Related Progression of Attentional Impairment in ADHD and Its Attenuation by Past Diagnosis and Treatment

Abstract

Objective: The aim of the study is to evaluate attentional impairment in different age groups with ADHD. Method: In all, 58 children, 73 adolescents, and 104 adults with ADHD were evaluated using the Test of Variables of Attention (TOVA). Subjects with comorbidities or psychotropic treatment were not included. Results: Considering Response Time Variability (RTV), adults were 10.6 and 4.0 times more likely to be severely impaired (standard score < 40) than children and adolescents, respectively. Adults were twice as likely as adolescents to be very impaired (standard score< 70) in Omissions. Considering d′ (decrement of attentional performance over time), all severely impaired participants were adults. Age predicted impairment in Attention Performance Index (API), RTV, and d′, but not Omissions or Commissions. Past treatment with stimulants predicted less impairment in d′, past diagnosis predicted less impairment in RTV, and each predicted less impairment in Omissions and API. Conclusion: Adults had more attentional impairment than children and adolescents. Past diagnosis and treatment were associated with less ADHD-related attentional impairment.

Keywords

ADHD impairment TOVA stimulants past treatment past diagnosis

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References

American Psychiatric Association. (2013). Attention-deficit/hyperactivity disorder. In Diagnostic and statistical manual of mental disorders (5th ed., p. 59). Arlington, VA: American Psychiatric Publishing.

Ben-Sheetrit

Zurawel

Weizman

Manor

(2016). Symptoms versus impairment in adults with ADHD: Intercorrelations of the BRIEF-A, CAARS, and TOVA. Journal of Attention Disorders, 1087054716682334. doi:10.1177/1087054716682334

Berardi

Parasuraman

Haxby

J. V.

(2001). Overall vigilance and sustained attention decrements in healthy aging. Experimental Aging Research, 27, 19-39.

Berger

Slobodin

Aboud

Melamed

Cassuto

(2013). Maturational delay in ADHD: Evidence from CPT. Frontiers in Human Neuroscience, 7, Article 691.

Biederman

Mick

Faraone

S. V.

(2000). Age-dependent decline of symptoms of attention deficit hyperactivity disorder: Impact of remission definition and symptom type. American Journal of Psychiatry, 157, 816-818.

Deaton

J. E.

Parasuraman

(1993). Sensory and cognitive vigilance: Effects of age on performance and subjective workload. Human Performance, 6, 71-97.

Forbes

G. B.

(1998). Clinical utility of the Test of Variables of Attention (TOVA) in the diagnosis of attention-deficit/hyperactivity disorder. Journal of Clinical Psychology, 54, 461-476.

Giambra

L. M.

Quilter

R. E.

(1988). Sustained attention in adulthood: A unique, large-sample, longitudinal and multicohort analysis using the Mackworth Clock Test. Psychology and Aging, 3, 75-83.

Greenberg

L. M.

Kindschi

C. L.

Dupuy

T. R.

Hughes

S. J.

(1994). Test of Variables of Attention continuous performance test. Los Alamitos, CA: The TOVA.

10.

Greenberg

L. M.

Waldmant

I. D.

(1993). Developmental normative data on the test of variables of attention (TOVA™). Journal of Child Psychology and Psychiatry, 34, 1019-1030.

11.

Gridley

M. C.

Mack

J. L.

Gilmore

G. C.

(1986). Age effects on a nonverbal auditory sustained attention task. Perceptual and Motor Skills, 62, 911-917.

12.

Haavik

Halmøy

Lundervold

A. J.

Fasmer

O. B.

(2010). Clinical assessment and diagnosis of adults with attention-deficit/hyperactivity disorder. Expert Review of Neurotherapeutics, 10, 1569-1580.

13.

Kofler

M. J.

Rapport

M. D.

Sarver

D. E.

Raiker

J. S.

Orban

S. A.

Friedman

L. M.

Kolomeyer

E. G.

(2013). Reaction time variability in ADHD: A meta-analytic review of 319 studies. Clinical Psychology Review, 33, 795-811.

14.

Lara

Fayyad

De Graaf

Kessler

R. C.

Aguilar-Gaxiola

Angermeyer

. . . Sampson

(2009). Childhood predictors of adult attention-deficit/hyperactivity disorder: Results from the world health organization world mental health survey initiative. Biological Psychiatry, 65, 46-54.

15.

Levy

(1980). The development of sustained attention (vigilance) and inhibition in children: Some normative data. Journal of Child Psychology and Psychiatry, 21, 77-84.

16.

Lin

C. C.

Hsiao

C. K.

Chen

W. J.

(1999). Development of sustained attention assessed using the continuous performance test among children 6–15 years of age. Journal of Abnormal Child Psychology, 27, 403-412.

17.

Manor

Rubin

Daniely

Adler

L. A.

(2014). Attention benefits after a single dose of metadoxine extended release in adults with predominantly inattentive ADHD. Postgraduate Medicine, 126(5), 7-16.

18.

Manor

Harary

Rubin

Daniely

(2015). A randomized, double-blind, placebo-controlled, multi-center, fixed dose study evaluating the safety and tolerability of a single administration of MDX (metadoxine extended release) in adolescents with predominantly inattentive ADHD. Poster presented at the 62nd Annual Meeting of the Amercian Academy of Child and Adolescent Psychiatry (AACAP).

19.

Molina

B. S.

Hinshaw

S. P.

Swanson

J. M.

Arnold

L. E.

Vitiello

Jensen

P. S.

. . . Houck

P. R.

(2009). The MTA at 8 years: prospective follow-up of children treated for combined-type ADHD in a multisite study. Journal of the American Academy of Child & Adolescent Psychiatry, 48, 484-500.

20.

Neal

G. L.

Pearson

R. G.

(1966). Comparative effects of age, sex, and drugs upon two tasks of auditory vigilance. Perceptual and Motor Skills, 23, 967-974.

21.

Schatz

A. M.

Ballantyne

A. O.

Trauner

D. A.

(2001). Sensitivity and specificity of a computerized test of attention in the diagnosis of attention-deficit/hyperactivity disorder. Assessment, 8, 357-365.

22.

Slobodin

Cassuto

Berger

(2015). Age-related changes in distractibility: Developmental trajectory of sustained attention in ADHD. J Atten Disord, 1087054715575066. doi:10.1177/1087054715575066.

23.

Surwillo

W. W.

Quilter

R. E.

(1964). Vigilance, age, and response-time. The American Journal of Psychology, 77, 614-620.

24.

Tenenbaum

Y. S.

Weizman

Rehavi

(2015). The impact of chronic early administration of psychostimulants on brain expression of BDNF and other neuroplasticity-relevant proteins. Journal of Molecular Neuroscience, 57, 231-242.

25.

Thompson

L. W.

Opton

Jr. Cohen

L. D.

(1963). Effects of age, presentation speed, and sensory modality on performance of a “vigilance” task. The Journal of Gerontology, 18, 366-369.

26.

Tune

(1966). Age differences in errors of commission. British Journal of Psychology, 57, 391-392.

27.

York

C. M.

(1962). Behavioral efficiency in a visual monitoring task as a function of signal rate and observer age. Perceptual and Motor Skills, 15, Article 404.