Compared to primary thrombocytosis such as that caused by essential thrombocytosis, reactive thrombocytosis is generally regarded as benign. However, reactive thrombocytosis has infrequently been reported to cause severe and even fatal complications. Two fatal cases of reactive thrombocytosis and iron deficiency anemia associated with peripheral/pulmonary vascular and cerebrovascular thrombosis are described. The literature on thrombosis and reactive thrombocytosis associated with iron deficiency anemia is reviewed.
Wu KK. Platelet hyperaggregability and thrombosis in patients with thrombocythemia. Ann Intern Med1978;88:7.
2.
Crowley JJ, Hannigan M, Daly K.Reactive thrombocytosis and stroke following cardiopulmonary bypass surgery: Case report on three patients. Eur Heart J1994;15:1144.
Gross S, Keefer V, Newman AJ. The platelets in iron-deficiency anemia. I. The response to oral and parenteral iron. Pediatrics1964;34:315.
5.
Karpatkin S, Garg SK, Freedman ML. Role of iron as a regulator of thrombopoiesis. Am J Med1974;57:521.
6.
Greer M.Uncommon causes of stroke. Part 2. Changes in blood constituents and hemodynamic factors. Geriatrics1978;33:51.
7.
Hart RG, Kanter MC. Hematologic disorders and ischemic stroke. A selective review. [see comments.]. [Review] [196 refs]. Stroke1990;21:1111.
8.
Chan AK, deVeber G.Prothrombotic disorders and ischemic stroke in children. [Review] [72 refs]. Semin Pediatr Neurol2000;7:301.
9.
Akan H, Guven N, Aydogdu I, Arat M, Beksac M, Dalva K.Thrombopoietic cytokines in patients with iron deficiency anemia with or without thrombocytosis. Acta Haematol2000;103:152.
10.
Ready WK, Lowry NJ. Anemia causing cerebral infarction in a child. CMAJ1989;140:303.
11.
Belman AL, Roque CT, Ancona R, Anand AK, Davis RP. Cerebral venous thrombosis in a child with iron deficiency anemia and thrombocytosis. Stroke1990;21:488.
12.
Bruggers CS, Ware R, Altman AJ, Rourk MH, Vedanarayanan V, Chaffee S.Reversible focal neurologic deficits in severe iron deficiency anemia. J Pediatr1990;117:430.
13.
Matsuoka Y, Hayasaka S, Yamada K.Incomplete occlusion of central retinal artery in a girl with iron deficiency anemia. Ophthalmologica1996;210:358.
14.
Hartfield DS, Lowry NJ, Keene DL, Yager JY. Iron deficiency: A cause of stroke in infants and children. Pediatr Neurol1997;16:50.
15.
Swann IL, Kendra JR. Severe iron deficiency anaemia and stroke. Clin Lab Haematol2000;22:221.
16.
Meena AK, Naidu KS, Murthy JM. Cortical sinovenous thrombosis in a child with nephrotic syndrome and iron deficiency anaemia. Neurol India2000;48:292.
17.
Kirkham TH, Wrigley PF, Holt JM. Central retinal vein occlusion complicating iron deficiency anaemia. Br J Ophthalmol1971;55:777.
18.
Knizley H. Jr, Noyes WD. Iron deficiency anemia, papilledema, thrombocytosis, and transient hemiparesis. Arch Intern Med1972;129:483.
19.
Alexander MB. Iron deficiency anemia, thrombocytosis, and cerebrovascular accident. South Med J1983;76:662.
20.
Heller DS, Pervez NK, Kleinerman J.Fatal cerebrovascular thrombosis in a young woman: An unusual complication associated with hypochromic anemia and thrombocytosis following surgery. Mt Sinai J Med1988;55:318.
21.
Aoki N, Sakai T.Cerebral sinus thrombosis in patients with severe iron deficiency anaemia due to myoma uteri. Acta Neurochir (Wien)1989;97:131.
22.
Stehle G, Buss J, Heene DL. Noninfectious thrombosis of the superior sagittal sinus in a patient with iron deficiency anemia. Stroke1991;22:414.
23.
Saxena VK, Brands C, Crols R, Moens E, Marien P, de Deyn PP. Multiple cerebral infarctions in a young patient with secondary thrombocythemia due to iron deficiency anemia. Acta Neurol (Napoli)1993;15:297.
24.
Shibuya Y, Hayasaka S.Central retinal vein occlusion in a patient with anorexia nervosa. Am J Ophthalmol1995;119:109.
25.
Akins PT, Glenn S, Nemeth PM, Derdeyn CP. Carotid artery thrombus associated with severe iron-deficiency anemia and thrombocytosis. Stroke1996;27:1002.
26.
Kacer B, Hattenbach LO, Horle S, Scharrer I, Kroll P, Koch F.Central retinal vein occlusion and nonarteritic ischemic optic neuropathy in 2 patients with mild iron deficiency anemia. Ophthalmologica2001;215:128.
