Seasonal Variation in the Incidence of Deep Vein Thrombosis in Patients With Deficiency of Protein C or Protein S

Abstract

An attempt was made to identify circaseptanal or seasonal variation of deep vein thrombosis (DVT) in a population with protein C or protein S deficit. Forty-four patients with DVT and protein C or protein S deficit were studied for 1 year. A significant circannual rhythm was found for the total population that peaked during winter. There was also a significant falling circaseptanal rhythm on Fridays. These observations may optimize an adequate and precise anticoagulant therapy in patients witi protein C or protein S deficits.

Keywords

Circannual rhythm Circaseptanal rhythm Deep vein thrombosis Protein C Protein S.

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