Thrombocytopenia in Patients Receiving Oral Anticoagulant Therapy

Abstract

The aim of this report was to determine the frequency of thrombocytopenia in a cohort of 1,126 patients receiving oral anti- coagulant therapy (OAT), and to compare the grade of thrombocy- topenia and the severity of bleeding complications. Severe thrombo- cytopenia was observed in five patients, and moderate and light thrombocytopenia were observed in 208 patients. Thrombocytopenic patients receiving OAT presented five major and six minor hemor- rhages. The presence of hepatitis markers and autoantibodies was assessed. All parameters at the time of the bleeding complication were in the therapeutic range.

Keywords

Thrombocytopenia Oral anticoagulant therapy Bleeding complications

References

1. Palareti G . Oral anticoagulant therapy today: Efficacy, safety, open problems. Ital Heart J 2000;1(Suppl 3):S126-S126.

2. Baker WF Jr , Bick RL . Treatment of hereditary and ac- quired thrombophilic disorders. Semin Thromb Hemost 1999;25:387-387.

3. Bick R . Vascular thrombohemorrhagic disorders: Hered- itary and acquired. Clin Appl Thromb Hemost 2001;7(3):178-178.

4. De Loughery TG . Anticoagulant therapy in special cir- cumstances. Curr Cardiol Rep 2000;2(1):74-74.

5. Bick RL . Antiphospholipid thrombosis syndromes. Clin Appl Thromb Hemost 2001;7(4):241-241.

6. Beyth RJ . Hemorrhagic complications of oral anticoagu- lant therapy [Review]. Clin Geriatr Med 2001; 17(1):49-49.

7. Levine MN , Raskob G , Landefeld S . Hemorrhagic compli- cations of anticoagulant treatment [Review]. Chest 2001;119(Suppl 1):108S-108S.

8. Palareti G , Leali N , Coccheri S . Bleeding complication of oral anticoagulant treatment: An inception-cohort, prospective collaborative study (ISCOAT). Italian study on complications of oral anticoagulant therapy. Lancet 1996;348(9025):423-423.

9. Sebastian JL , Tresch DD . Use of oral anticoagulant thera- py in older patients [Review]. Drugs Aging 2000;16(6): 409-409.

10.

10. Kanaoka Y , Tanemoto K , Murakami T . Thromboembolic and bleeding complications in patient treated with oral anticoagulant therapy after mechanical heart valve pros- theses implantation. Kyobu Geka 2000;53(9):754-754.

11.

11. Ben-Ami R , Berliner S . Anticoagulant therapy in atrial flut- ter [Review]. Harefuah 1998;134(10):813-813.

12.

12. Fartoukh M , Simonneau G . Strategies for utilization of an- ticoagulants in pulmonary embolism. Rev Mal Respir 1999; 16(5 Pt 2):949-949.

13.

13. Guilloton L , Godon P , Drouet A . Retroclival hematoma in a patient taking oral anticoagulants. Rev Neurol (Paris) 2000;156(4):392-392.

14.

14. Cihangiroglu M , Bulut S , Nayak S . Spinal subarachnoid hemorrhage complicating oral anticoagulant therapy. Eur J Radiol 2001;39(3):176-176.

15.

15. Vaya A , Resurreccion M , Ricart JM . Spontaneous cervical epidural hematoma associated with oral anticoagulant therapy. Clin AppI Thromb Hemost 2001;7(2):166-166.