Reduced cigarette smoke exposure in adult smokers switching from a conventional cigarette (CC) to a potential exposure-reduced electrically heated cigarette smoking system (EHCSS) and no smoking (NS) improved exercise performance. The effects of reduced smoke exposure on the prognostic parameters heart rate (HR) and rate—pressure-product (RPP) were investigated. A total of 18 male adult CC-smokers were randomized in a 3-period cross-over study to CC, EHCSS, or to NS for 3 days each before performing spiroergometry. Exposure parameters declined from CC to EHCSS and to NS. Resting HR and RPP increased from NS to EHCSS and to CC. Chronotropic response/HR recovery were more pronounced in NS than in EHCSS and CC. RPPmax was similar in NS and EHCSS and lowest during CC. Reduced tobacco smoke exposure for 3 days improved the prognostic parameters HR and RPP in an apparently dose-dependent manner.
Stratton K., Shetty P., Wallace R., Bondurant S.Clearing the smoke: the science base for tobacco harm reduction-executive summary. Tob Control. 2001;10:189-195.
2.
McBride PEThe health consequences of smoking. Cardiovascular diseases. Med Clin North Am.1992;76: 333-353.
3.
Lekakis J., Papamichael C., Vemmos C., et al. Effect of acute cigarette smoking on endothelium-dependent brachial artery dilatation in healthy individuals. Am J Cardiol. 1997;79:529-531.
4.
Kyriakides ZS , Kremastinos DT, Rentoukas E., Mavrogheni S., Kremastinos DI, Toutouzas P.Acute effects of cigarette smoking on left ventricular diastolic function. Eur Heart J. 1992;13:743-748.
5.
Alam M., Samad BA, Wardell J., Andersson E., Hoglund C., Nordlander R.Acute effects of smoking on diastolic function in healthy participants: studies by conventional Doppler echocardiography and Doppler tissue imaging. J Am Soc Echocardiogr. 2002;15:1232-1237.
6.
Stork T., Danne O., Muller R., Mockel M., Hochrein H.Effect of smoking on relaxation and filling behavior of the left ventricle in healthy probands. An echocardiography study [in German]. Med Klin.1991;86:173-179.
7.
Stork T., Eichstadt H., Mockel M., Bortfeldt R., Muller R., Hochrein H.Changes of diastolic function induced by cigarette smoking: an echocardiographic study in patients with coronary artery disease. Clin Cardiol . 1992;15:80-86.
8.
Karakaya O., Barutcu I., Esen AM, et al. Acute smoking-induced alterations in Doppler echocardiographic measurements in chronic smokers. Tex Heart Inst J. 2006;33:134-138.
9.
Gembala MI, Ghanem F., Mann CA, Sorrell VLAcute changes in left ventricular diastolic function: cigarette smoking versus nicotine gum. Clin Cardiol. 2006;29:61-64.
10.
Behr MJ, Leong KH, Jones RHAcute effects of cigarette smoking on left ventricular function at rest and exercise. Med Sci Sports Exerc. 1981;13:9-12.
11.
Ijzerman RG , Serne EH, van Weissenbruch MM, de Jongh RT, Stehouwer CDCigarette smoking is associated with an acute impairment of microvascular function in humans . Clin Sci (Lond). 2003;104:247-252.
12.
Hayano J., Yamada M., Sakakibara Y., et al. Short- and long-term effects of cigarette smoking on heart rate variability. Am J Cardiol. 1990;65:84-88.
13.
Task Force of the European Society of Cardiology and the North American Society of Pacing and Electrophysiology. Heart rate variability: standards of measurement, physiological interpretation and clinical use. Circulation. 1996; 93:1043-1065.
14.
Minami J., Ishimitsu T., Matsuoka H.Effects of smoking cessation on blood pressure and heart rate variability in habitual smokers. Hypertension. 1999;33:586-590.
15.
Hashizume K. , Yamaji K., Kusaka Y., Kawahara K.Effects of abstinence from cigarette smoking on the cardiorespiratory capacity. Med Sci Sports Exerc. 2000;32:386-391.
16.
Leon AS, Jacobs DR Jr, DeBacker G., Taylor HLRelationship of physical characteristics and life habits to treadmill exercise capacity. Am J Epidemiol. 1981;113: 653-660.
17.
Unverdorben M., der Bijl A., Potgieter L., Liang Q., Meyer BH, Roethig HJSpiroergometry in adult smokers comparing a conventional cigarette to an electrically heated cigarette smoking system . Prev Cardiol. 2007;10:83-91.
18.
Myers J., Prakash M., Froelicher V., Do D., Partington S., Atwood JEExercise capacity and mortality among men referred for exercise testing. N Engl J Med. 2002;346:793-801.
19.
Aktas MK, Ozduran V., Pothier CE, Lang R., Lauer MSGlobal risk scores and exercise testing for predicting all-cause mortality in a preventive medicine program. JAMA. 2004 ;292:1462-1468.
20.
Sandvik L., Erikssen J., Ellestad M., et al. Heart rate increase and maximal heart rate during exercise as predictors of cardiovascular mortality: a 16-year follow-up study of 1960 healthy men. Coron Artery Dis.1995;6:667-679.
21.
Lauer MS, Okin PM, Larson MG, Evans JC, Levy D.Impaired heart rate response to graded exercise. Prognostic implications of chronotropic incompetence in the Framingham Heart Study. Circulation. 1996;93:1520-1526.
22.
Jouven X., Empana JP, Schwartz PJ, Desnos M., Courbon D., Ducimetiere P.Heart-rate profile during exercise as a predictor of sudden death. N Engl J Med. 2005;352: 1951-1958.
23.
Lauer MS, Francis GS, Okin PM, Pashkow FJ, Snader CE, Marwick THImpaired chronotropic response to exercise stress testing as a predictor of mortality. JAMA. 1999; 281:524-529.
24.
Lauer MS, Pashkow FJ, Larson MG, Levy D.Association of cigarette smoking with chronotropic incompetence and prognosis in the Framingham Heart Study. Circulation. 1997;96:897-903.
25.
Cole C., Blackstone E., Pashkow F., Snader C., Lauer M.Heart-rate recovery immediately after exercise as a predictor of mortality . N Engl J Med. 1999;341:1351-1357.
26.
Nishime EO, Cole CR, Blackstone EH, Pashkow FJ, Lauer MSHeart rate recovery and treadmill exercise score as predictors of mortality in patients referred for exercise ECG. JAMA. 2000;284:1392.
27.
Kobayashi Y. , Takeuchi T., Hosoi T., Loeppky JAEffects of habitual smoking on cardiorespiratory responses to sub-maximal exercise. J Physiol Anthropol Appl Human Sci. 2004;23:163-169.
28.
Morshedi-Meibodi A., Larson MG, Levy D., O'Donnell CJ, Vasan RSHeart rate recovery after treadmill exercise testing and risk of cardiovascular disease events (The Framingham Heart Study) . Am J Cardiol. 2002;90:848-852.
29.
Elhendy A., Modesto KM, Mahoney DW, Khandheria BK, Seward JB, Pellikka PAPrediction of mortality in patients with left ventricular hypertrophy by clinical, exercise stress, and echocardiographic data. J Am Coll Cardiol . 2003;41:129-135.
30.
Al Khalili F. , Svane B., Wamala SP, Orth-Gomér K., Rydén L., Schenck-Gustafsson K.Clinical importance of risk factors and exercise testing for prediction of significant coronary artery stenosis in women recovering from unstable coronary artery disease: the Stockholm Female Coronary Risk Study. Am Heart J.2000 ;139:971-978.
31.
Villella M., Villella A., Barlera S., Franzosi M., Maggioni A.Prognostic significance of double product and inadequate double product response to maximal symptom-limited exercise stress testing after myocardial infarction in 6296 patients treated with thrombolytic agents. GISSI-2 Investigators. Grupo Italiano per lo Studio della Sopravvivenza nell-Infarto Miocardico. Am Heart J.1999;137:443-452.
32.
Roethig HJ, Kinser RD, Lau RW, Walk RA, Wang N.Short-term exposure evaluation of adult smokers switching from conventional to first-generation electrically heated cigarettes during controlled smoking . J Clin Pharmacol. 2005;45:133-145.
33.
Roethig HJ, Zedler BK, Kinser RD, Feng S., Nelson BL, Liang Q.Short-term clinical exposure evaluation of a second-generation electrically heated cigarette smoking system. J Clin Pharmacol. 2007;47:518-530.
Smith R.Toxic responses of the blood. In: Klassen C, Amdur M, Doull J, eds. Casarett and Doull's Toxicology, the Basic Science of Poisons. 3rd ed. New York, NY: Macmillan; 1986:233-244.
36.
Zuckerbraun BS, Chin BY, Bilban M., et al. Carbon monoxide signals via inhibition of cytochrome c oxidase and generation of mitochondrial reactive oxygen species . FASEB J. 2007;21:1099-1106.
37.
Piantadosi CABiological chemistry of carbon monoxide. Antioxid Redox Signal. 2002;4:259-270.
38.
Durante W., Johnson FK, Johnson RATargeting heme oxygenase-1 in the treatment of atherosclerosis. Drug Discov Today Ther Strateg. 2005;2:201-206.
39.
Grassi G., Seravalle G., Calhoun DA, et al. Mechanisms responsible for sympathetic activation by cigarette smoking in humans. Circulation. 1994;90:248-253.
40.
Terres W., Becker P., Rosenberg A.Changes in cardiovascular risk profile during the cessation of smoking. Am J Med. 1994;97:242-249.
41.
Koch A., Hoffmann K., Steck W., et al. Acute cardiovascular reactions after cigarette smoking. Atherosclerosis. 1980;35:67-75.
42.
Kahles H., Dreyling M., Kaposciok J., et al. Validation of indirect myocardial parameters of oxygen consumption in patients with normal and pathologically changed ventricular function [in German]. Z Kardiol. 1989;78 :285-293.
43.
Cohn JN, Johnson G.Heart failure with normal ejection fraction. The V-HeFT Study. Veterans Administration Cooperative Study Group. Circulation. 1990 ;81:I1148-I1153.
44.
Kruger S., Hoffmann R., Skobel E., Breuer C., Janssens U., Hanrath P.Impairment of ventilatory parameters and exercise capacity in patients with pulmonary hypertension and chronic heart insufficiency [in German]. Dtsch Med Wochenschr. 2002;127: 839-844.
45.
Leon AS, Connett J.Physical activity and 10.5 year mortality in the Multiple Risk Factor Intervention Trial (MRFIT). Int J Epidemiol.1991;20:690-697.
46.
Leon AS, Myers MJ, Connett J.Leisure time physical activity and the 16-year risks of mortality from coronary heart disease and all-causes in the Multiple Risk Factor Intervention Trial (MRFIT). Int J Sports Med. 1997;18 (suppl 3):S208-S215.
47.
Williams PTPhysical fitness and activity as separate heart disease risk factors: a meta-analysis. Med Sci Sports Exerc . 2001;33:754-761.
48.
Jouven X., Zureik M., Desnos M., Guérot C., Ducimetière P.Resting heart rate as a predictive risk factor for sudden death in middle-aged men. Cardiovasc Res. 2001;50:373-378.
49.
Rahimi K., Thomas A., Adam M., Hayerizadeh BF, Schuler G., Secknus MAImplications of exercise test modality on modern prognostic markers in patients with known or suspected coronary artery disease: treadmill versus bicycle . Eur J Cardiovasc Prev Rehabil. 2006;13: 45-50.
50.
Matthys D., Pannier JL, Taeymans Y., Verhaaren H.Cardiorespiratory variables during a continuous ramp exercise protocol in normal young adults. Acta Cardiol. 1996;51:451-459.
