Directed growth cone movements in response to external guidance signals are required for the establishment of functional neuronal connections during development, adult nerve regeneration, and adult neurogenesis. Growth cone intrinsic properties permit different growth cone responses (e.g., attraction or repulsion) to a guidance signal, and alterations to these intrinsic properties often result in opposite growth cone responses. This article reviews the current knowledge of growth cone signaling, emphasizing the dependency of Ca2+ signaling on membrane potential shifts, and cyclic nucleotide and phosphoinositide signaling pathways during growth cone turning in response to guidance signals. We also discuss how asymmetrical growth cone signaling is achieved for the fine-tuned growth cone movement.
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