Glial cells are instrumental for many aspects of nervous-system function. Interestingly, complex neuron—glial interactions at synapses are commonly found in both invertebrates and vertebrates. Although these interactions are known to be important for synaptic physiology, the cellular processes and molecular mechanisms involved have not been fully uncovered. Identifying the common and unique features of neuron—glial interactions between invertebrates and vertebrates may provide valuable insights into the relationship of neuron—glial cross-talk to nervous-system function. This review highlights selected studies that have revealed structural and functional insights into neuron—glial interactions at synapses in invertebrate and vertebrate model systems. NEUROSCIENTIST 13(6): 657—666, 2007. DOI: 10.1177/1073858407304393
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