Esophageal cancer is a challenging clinical problem with an estimated 12,300 new cases diagnosed in 1998.
Methods:
A detailed review of pertinent literature is used to describe the epidemiology and management of this disease.
Results:
Radiation therapy remains an important cornerstone of therapy. In combination with chemotherapy and/or surgery, radiation therapy may offer an improved therapeutic outcome.
Conclusions:
Radiation therapy remains an important therapy in the treatment of esophageal cancer.
References
1.
LandisS.H., MurrayT., BoldenS.. Cancer statistics, 1998.CA Cancer J Clin.1998; 48: 6–29.
2.
RosenbergJ.C., FranklinR., SteigerZ.. Squamous cell carcinoma of the thoracic esophagus: an interdisciplinary approach.Curr Probl Cancer.1981; 5: 1–52.
3.
WatsonW.L., GoodnerJ.T., MillerT.P.. Torek esophagectomy: the case against segmental resection for esophageal cancer.J Thorac Surg.1956; 32: 347.
4.
AndersonL.L., LadT.E.. Autopsy findings in squamous-cell carcinoma of the esophagus.Cancer.1982; 50: 1587–1590.
5.
YangP.C., DavisS.. Incidence of cancer of the esophagus in the US by histologic type.Cancer.1988; 61: 612–617.
6.
BlotW.J., DevesaS.S., FraumeniJFJr. Continuing climb in rates of esophageal adenocarcinoma: an update.JAMA.1993; 270: 1320.
7.
BlotW.J.. Esophageal cancer trends and risk factors.Semin Oncol.1994; 21: 403–410.
8.
MacDonaldW.C., MacDonaldJ.B.. Adenocarcinoma of the esophagus and/or gastric cardia.Cancer.1987; 60: 1094–1098.
9.
AppelqvistP.. Carcinoma of the oesophagus and gastric cardia at autopsy in Finland.Ann Clin Res.1975; 7: 334–340.
10.
MandardA.M., ChasleJ., MarnayJ.. Autopsy findings in 111 cases of esophageal cancer.Cancer.1981; 48: 329–335.
11.
AisnerJ., ForastiereA., AroneyR.. Patterns of recurrence for cancer of the lung and esophagus. In: WittesR.E., ed. Cancer Treatment Symposia: Proceedings of the Workshop on Patterns of Failure After Cancer Treatment. Vol 2. Washington DC: US Department of Health and Human Services, 1983: 87.
12.
EarlamR., Cunha-MeloJr. Oesophageal squamous cell carcinoma, I: a critical review of surgery.Br J Surg.1980; 67: 384.
13.
AkiyamaH., TsurumaruM., KawamuraT.. Principles of surgical treatment for carcinoma of the esophagus: analysis of lymph node involvement.Ann Surg.1981; 194: 438–446.
14.
SchlagP.M.. Randomized trial of preoperative chemotherapy for squamous cell cancer of the esophagus. The Chirurgische Arbeitsgemeinschaft Fuer Onkoligie der Deutschen Gesellschaft Fuer Chirurgie Study Group.Arch Surg.1992; 127: 1446–1450.
15.
EarlamR.. An MRC prospective randomised trial of radiotherapy versus surgery for operable squamous cell carcinoma of the oesophagus.Ann R Coll Surg Engl.1991; 73: 8–12.
16.
BeattyJ.D., DeBoerG., RiderW.D.. Carcinoma of the esophagus: pretreatment assessment, correlation of radiation treatment parameters with survival, and identification and management of radiation treatment failure.Cancer.1979; 43: 2254–2267.
17.
van AndelJ.G., DeesJ., DijkhuisC.M.. Carcinoma of the esophagus: results of treatment.Ann Surg.1979; 190: 684–689.
18.
SunD.R.. Ten-year follow-up of esophageal cancer treated by radical radiation therapy: analysis of 869 patients.Int J Radiat Oncol Biol Phys.1989; 16: 329–334.
19.
NewaishyG.A., ReadG.A., DuncanW.. Results of radical radiotherapy of squamous cell carcinoma of the oesophagus.Clin Radiol.1982; 33: 347–352.
20.
EarlamR., Cunha-MeloJ.R.. Oesophageal squamous cell carcinoma: II. A critical view of radiotherapy.Br J Surg.1980; 67: 457–461.
21.
JunW., GuoB.Z., GaoS.Z.. Accelerated hyperfractionated radiotherapy in esophageal cancer: an analysis of 172 cases.Chin Med J.1991; 104: 228.
22.
JunW., GuoB.Z., GaoS.Z.. Study of radiation dosage in esophageal carcinoma.Chin Med J.1992; 105: 132.
23.
NishimuraY., OnoK., TsutsuiK.. Esophageal cancer treated with radiotherapy: impact of total treatment time and fractionation.Int J Radiat Oncol Biol Phys.1994; 30: 1099–1105.
24.
GignouxM., RousselA., PaillotB.. The value of preoperative radiotherapy in esophageal cancer: results of a study of the EORTC.World J Surg.1987; 11: 426–432.
25.
LaunoisB., DelarueD., CampionJ.P.. Preoperative radiotherapy for carcinoma of the esophagus.Surg Gynecol Obstet.1981; 153: 690–692.
26.
WangM., GuX.Z., YinW.B.. Randomized clinical trial on the combination of preoperative irradiation and surgery in the treatment of esophageal carcinoma: report on 206 patients.Int J Radiat Oncol Biol Phys.1989; 16: 325–327.
27.
ArnottS.J., DuncanW., KerrG.R.. Low dose preoperative radiotherapy for carcinoma of the oesophagus: results of a randomized clinical trial.Radiother Oncol.1992; 24: 108–113.
28.
NygaardK., HagenS., HansenH.S.. Pre-operative radiotherapy prolongs survival in operable esophageal carcinoma: a randomized, multicenter study of pre-operative radiotherapy and chemotherapy. The second Scandinavian trial in esophageal cancer.World J Surg.1992; 16: 1104–1109.
29.
KasaiM., MoriS., WatanabeT.. Follow-up results after resection of thoracic esophageal carcinoma.World J Surg.1978; 2: 543–551.
30.
TeniereP., HayJ.M., FingerhutA.. Postoperative radiation therapy does not increase survival after curative resection for squamous cell carcinoma of the middle and lower esophagus as shown by a multicenter controlled trial: French University Association for Surgical Research.Surg Gynecol Obstet.1991; 173: 123–130.
31.
FokM., ShamJ.S., ChoyD.. Postoperative radiotherapy for carcinoma of the esophagus: a prospective, randomized controlled study.Surgery.1993; 113: 138–147.
32.
GasparL.E., NagS., HerskovicA.. American Brachytherapy Society (ABS) consensus guidelines for brachytherapy for esophageal cancer. Clinical Research Committee, American Brachytherapy Society, Philadelphia, Pa.Int J Radiat Oncol Biol Phys.1997; 38: 127–132.
33.
GasparL.E., QianC., KochaW.I.. A phase I/II study of external beam radiation, brachytherapy and concurrent chemotherapy in localized cancer of the esophagus (RTOG 92-07): preliminary toxicity report.Int J Radiat Oncol Biol Phys.1997; 37: 593–599.
34.
RothJ.A., PassH.I., FlanaganM.M.. Randomized clinical trial of preoperative and postoperative adjuvant chemotherapy with cisplatin, vindesine and bleomycin for carcinoma of the esophagus.J Thorac Cardiovasc Surg.1988; 96: 242–248.
35.
KelsenD.P., GinsbergR., QianC.. Chemotherapy followed by operation versus operation alone in the treatment of patients with localized esophageal cancer: a preliminary report of the intergroup study 113 (RTOG 89-11).Proc Annu Meet Am Soc Clin Oncol.1997; 16: A982.
36.
ByfieldJ.E., BaroneR., MendelsohnJ.. Infusional 5-fluorouracil and X-ray therapy for non-resectable esophageal cancer.Cancer.1980; 45: 703–708.
37.
KolaricK., MaricicZ., RothA.. Combination of bleomycin and adriamycin with and without radiation on the treatment of inoperable esophageal cancer. A randomized study.Cancer.1980; 45: 2265–2273.
38.
EarleJ.D., GelberR.D., MoertelC.G.. A controlled evaluation of combined radiation and bleomycin therapy for squamous cell carcinoma of the esophagus.Int J Radiat Oncol Biol Phys.1980; 6: 821–826.
39.
CoiaL.R., EngstromP.F., PaulA.R.. Long-term results of infusional 5-FU, mitomycin-C and radiation as primary management of esophageal carcinoma.Int J Radiat Oncol Biol Phys.1991; 20: 29–36.
40.
SmithT.J., RyanL.M., DouglassHOJr. Combined chemoradiotherapy vs. radiotherapy alone for early stage squamous cell carcinoma of the esophagus: a study of the Eastern Cooperative Oncology Group.Int J Radiat Oncol Biol Phys.1998; 42: 269–276.
41.
al-SarrafM., MartzK., HerskovicA.. Progress report of combined chemoradiotherapy versus radiotherapy alone in patients with esophageal cancer: an intergroup study.J Clin Oncol.1997; 15: 277–284.
42.
RousselA., HaegeleP., PaillotB.. Results of the EORTC-GTCCG Phase III trial of irradiation vs irradiation and CDDP in inoperable esophageal cancer.Proc Annu Meet Am Soc Clin Oncol.1994; 13: A583.
43.
AraujoC.M., SouhamiL., GilR.A.. A randomized trial comparing radiation therapy versus concomitant radiation therapy and chemotherapy in carcinoma of the thoracic esophagus.Cancer.1991; 67: 2258–2261.
ForastiereA.A., OrringerM.B., Perez-TamayoC.. Preoperative chemoradiation followed by transhiatal esophagectomy for carcinoma of the esophagus: final report.J Clin Oncol.1993; 11: 1118–1123.
46.
ForastiereA.A., HeitmillerR.F., LeeD.J.. Intensive chemoradiation followed by esophagectomy for squamous cell and adenocarcinoma of the esophagus.Cancer J Sci Am.1997; 3: 144–152.
47.
BatesB.A., DetterbeckF.C., BernardS.A.. Concurrent radiation therapy and chemotherapy followed by esophagectomy for localized esophageal carcinoma.J Clin Oncol.1996; 14: 156–163.
48.
PoplinE., FlemingT., LeichmanL.. Combined therapies for squamous-cell carcinoma of the esophagus: a Southwest Oncology Group Study (SWOG-8037).J Clin Oncol.1987; 5: 622–628.
49.
SeydelH.G., LeichmanL., ByhardtR.. Preoperative radiation and chemotherapy for localized squamous cell carcinoma of the esophagus: an RTOG study.Int J Radiat Oncol Biol Phys.1988; 14: 33–35.
50.
KellerS.M., CoiaL.R., RyanL.. Chemo radiation followed by esophagectomy for adenocarcinoma of the esophagus and gastroesophageal junction: results of a phase II study of the ECOG.Proc Annu Meet Am Soc Clin Oncol.1995; 14: 196.
51.
PoplinE.A., JacobsonJ., HerskovicA.. Evaluation of multimodality treatment of locoregional esophageal carcinoma by Southwest Oncology Group 9060.Cancer.1996; 78: 1851–1856.
52.
WalshT.N., NoonanN., HollywoodD.. A comparison of multimodal therapy and surgery for esophageal adenocarcinoma.N Engl J Med.1996; 335: 462–467.
53.
BossetJ.F., GignouxM., TribouletJ.P.. Chemoradiotherapy followed by surgery compared with surgery alone in squamous-cell cancer of the esophagus.N Engl J Med.1997; 337: 161–167.
54.
Le PriseE., EtienneP.L., MeunierB.. A randomized study of chemotherapy, radiation therapy, and surgery versus surgery for localized squamous cell carcinoma of the esophagus.Cancer.1994; 73: 1779–1784.
55.
UrbaS., OrringerM., TurrisA.. A randomized trial comparing surgery (S) to preoperative concomitant chemoradiation plus surgery in patients (pts) with resectable esophageal cancer (CA): updated analysis.Proc Annu Meet Am Soc Clin Oncol.1997; 16: A983.
